Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Farmasi Indonesia
Ismi Rahmawati
Faculty of Pharmacy, Setia Budi University
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
Antioxidant Activity Test of 2,6-bis-(2’-furilidyn)-Cyclohexanone, ; 2,5-bis-(2’-furilidyn)-Cyclopentanone; 1,5-Difuryl-1,4-pentadien-3-one Ismi Rahmawati; Endang Sri Rejeki; Sardjiman Sardjiman
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp38-42

Abstract

Antioxidant is an essential compound to keep man’s health due to its function as radical scavenging. Curcumin analog compounds can function as antioxidant (Sardjiman, 2000). The aim of the experiment was to find out the antioxidant activity of 2,.6-bis-(2’-furilidin)-cyclohexanone, 2,.5-bis-(2’furilidin)-cyclopentanone, and 1,.5-difuril-1.4-pentadien-3-one compounds, and the antioxidant activity of each compound against DPPH  radical with IC50 parameter as well as the correlation of compounds structure’s activities against antioxidant. The antioxidant activity of curcumin analog compounds wereas tested against DPPH free radical. The test was conducted in 5 series of concentrations by adding 4.0 ml test solutions with 1.0 ml DPPH. The antioxidant activity against free radical was measured usingwith spectrophotometer at 517 nm wavelength and determined for the IC50 value. The experiment employed rutin as positive control. The result of the experiment showed that curcumin analog compounds have antioxidant activity with IC50 of rutin, 2,.6-bis-(2’-furilidin)-cyclohexanone, 2,.5-bis-(2’furilidin)-cyclopentanone, and 1,.5-difuril-1.4-pentadien-3-one as follows: 4.93 ppm, 22.73 ppm, 20.67 ppm, and 18.80 ppm  respectively. The highest antioxidant activity belonged to 1,.5-difuril-1.4-pentadien-3-one compound which is 18.80 ppm . Correlation of activity structure of the 3 compounds can be seen from the log p parameter and energy space of HOMO-LUMO.Key words: Antioxidant, DPPH, Analog Curcumin
Uji Aktivitas Antifungi Fraksi n-Heksan, Etil Asetat, dan Air dari Daun Pepaya (Carica Papaya Linn.) terhadap Candida albicans ATCC 10231 Ismi Rahmawati; Shinta Noviana; Yudi Rinanto
Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (673.024 KB) | DOI: 10.31001/jfi.v7i1.21

Abstract

Papaya leaf (Carica papaya, Linn) contains alkaloid, saponin and flavonoid. Papaya leaf can be used for treating whiteness, increasing appetite, treating malaria. The objective of this research is to find out the activity of macerate, n-hexane, ethyl-acetate, and water fractions of papaya leaf (Carica papaya, Linn) as antifungal agent to Candida albicans ATCC® 10231, the primary cause of candidiasis. The papaya leaf powder was macerated using ethanol 70%, that was then concentrated, followed with fractionation using water, ethyl acetate, and n-hexane solvent. The method employed in this research was dilution (tube dilution), method of antifungal test was conducted by dilution method a series of dilutions in various concentrations 100%; 50%; 25%; 12,5%; 6,25%; 3,12%; 1,56%; 0,78%; 0,39%; dan 0,195%(b/v). The result of research showed that ethyl acetate fraction of papaya leaf hs the most effective antifungal activity compared with the macerate, n-hexane and water fractions. Ethyl acetate fraction has Minimum Killing Concentration of 25% (b/v), macerate and n-hexane fraction have Minimum Killing Concentration of 50% (b/v), and water fraction does not have Minimum Killing Concentration on Candida albicans ATCC 10231.
Uji Aktivitas Antibakteri Ekstrak Etanolik Daun Sisik Naga (Drymoglossum piloselloides (L) Presl) terhadap Shigella dysenteriae ATCC 9361 dengan Metode Soxhletasi dan Perkolasi Tinuk Wuryandari; Bambang Iskamto; Ismi Rahmawati
Jurnal Farmasi Indonesia Vol 7 No 2 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (752.603 KB) | DOI: 10.31001/jfi.v7i2.23

Abstract

Leaves of Drymoglossum piloselloides [L.] Presl. were used as dysentery drug. The experiment was aimed to find out whether soxhletation and percolation extracts of Drymoglossum piloselloides [L.] Presl. leaves had antibacterial activity against Shigella dysenteriae ATCC 9361. Lleaves were dried and then blended to make powder. The extraction method used was soxhletation and percolation methods using ethanol 70% solvent. The obtained extract was evaporated until it was thick, and then the antibacterial activity test was conducted by dilution method against Shigella dysenteriae ATCC 9361. he concentrations of the test solutions were: 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78%, 0.39%, 0.19%. The result of the experiment showed that soxhletation and percolation extracts had antibacterial activity against Shigella dysenteriae ATCC 9361 test bacteria. There was no difference in antibacterial activity between soxhletation extract and percolation extract against Shigella dysenteriae ATCC 9361 showed by minimum bactericidal concentration i.e. 50% both.
Sintesis Senyawa 1,5-Difuril-1,4-Pentadien-3-On Ismi Rahmawati
Jurnal Farmasi Indonesia Vol 8 No 1 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4975.072 KB) | DOI: 10.31001/jfi.v8i1.36

Abstract

Modification on the curcumine structure by altering the β-diketon to monoketon resulting in the curcumine-analog compounds with antioxidan, antiinflamation, and antibacterial activity. The objectives of this research are to produce compound 1,5-difuril-1,4-pentadiene-3-one. The syntesis of the compounds used keton (aceton) and furfural as base materials and KOH as a catalyst in the akuades solvent. The purity test were carried out with thin layer chromatography, gas chromatography, and melting distance test. Structure elucidation was performed with IR spectrophotometer, H1-NMR and mass spectrometer analysis. The result of this study demonstrate that 1,5-difuril-1,4-pentadiene-3-one have been successfully synthesized and purified, and have chemical structure as expected. The yield of the synthesis yield is 85.99% and 60.13% is the result of recrystallization.
Uji Aktivitas Antijamur Kombinasi Berbagai Tanaman terhadap Pityrosporum ovale Ismi Rahmawati; Opstaria Saptarini; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (889.365 KB) | DOI: 10.31001/jfi.v11i1.52

Abstract

One cause of tinea versicolor is a fungal Pityrosporum ovale which colonizes on the skin. Previous research has examined the red betel leaves, beluntas leaves and cabbage leaves as antifungal against Pityrosporum ovale. This study aims to determine the effectiveness of the above herbs in the form of single or various combinations to inhibit the growth of the fungus Pityrosporum ovale by in vitro method. The extraction method was performed by infudation on the red betel leaf powder, beluntas leaves and cabbage leaves. The results of infudation are then made in a combination of (1:1), (1:3) and (3:1). The antifungal test with dilution method was then performed on the single and the combination extract. Dilution method was performed by making a series of dilutions in concentrations of 50%, 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, 0.39%, 0.19%, 0.09%. The results showed that the MKC (minimum killing concentration) of red betel leaves, beluntas leaves and cabbage leaves, combination of red betel leaves and beluntas leaves (1:1), (1:3) and (3:1), combination of red betel leaves and cabbage leaves (1:1), (1:3) and (3:1) were 50%, 25%, 25%, 25%, 12.5%, 50%, 50%, 12.5%, 25% respectively. The best combination were red betel leaves and beluntas leaves infusions with a ratio of (1:3) and the combination red betel leaves and cabbage leaves infusions with a ratio of (1:3).
AKTIVITAS ANTIBAKTERI DAN ANTIJAMUR KULIT BATANG KRANGEAN(Litsea cubeba Pers.) Mamik Ponco Rahayu; Ismi Rahmawati; Wahyu Listiantoro; Wayndy Chrisantoso
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.193 KB) | DOI: 10.31001/jfi.v12i2.92

Abstract

Litsea cubeba Pers or Krangean is a traditional medicinal plant widely used as an antidiarrheal, skin diseases, as well as antiseptic agent. In addition to essential oils, this herb also contains various components such as tannins, saponins, flavonoids and alkaloids. The purpose of the study was to determine the activities of n-hexane fraction, ethyl acetate, and water from the ethanolic extract of the Krangean stem bark as antibacterial and antifungal properties against E. coli ATCC 25922, S. aureus ATCC 25923 and C. albicans ATCC 1023. Krangean stem bark extraction was conducted by maceration method using 70% ethanol as solvent, followed by fractionation with n-hexane, ethyl acetate, and water as solvent. Antibacterial and antifungal activities were determined by diffusion and dilution method. Diffusion method was used to measure the diameter of the inhibitory area against bacteria colonies with concentrations used were 50%, 25%, as well as 12.5%. Dilution method (dilution tubes), was conducted in serial dilutions of various concentrations, 50%, 25%; 12.5%, 6.25%; 3.12%; 1.56%; 0.78%; 0.39%; and 0.195%. The results showed that n-hexane fraction of the ethanolic extract of the Krangean’ stem bark had the highest activity against E. coli ATCC 25922 and C. albicans ATCC 10231 compared to other fractions, based on the average of diameter inhibition values. The diffusion method showed that nhexane fraction at concentration of 50% had inhibitory activity against E. coli ATCC 25922, and C. albicans ATCC 10231 with the average inhibitory power were 30 ± 0,00 mm and 20,4 ± 0,58 mm, respectively. n-Hexane fraction could kill E. coli ATCC 25922, and C. albicans ATCC 10231 with the Minimum Killing Inhibitory Concentration (MKC) value were 1.56%, and 0.39%, respectively.The presence of essential oils and triterpenoid in n-hexane fraction were detected in the preliminary phytochemical tests.
Co-Authors Bambang Iskamto Endang Sri Rejeki Mamik Ponco Rahayu Opstaria saptarini Sardjiman Sardjiman Shinta Noviana Tinuk Wuryandari Wahyu Listiantoro Wayndy Chrisantoso Yudi Rinanto