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Antioxidant Activity Test of 2,6-bis-(2’-furilidyn)-Cyclohexanone, ; 2,5-bis-(2’-furilidyn)-Cyclopentanone; 1,5-Difuryl-1,4-pentadien-3-one Ismi Rahmawati; Endang Sri Rejeki; Sardjiman Sardjiman
Indonesian Journal of Cancer Chemoprevention Vol 1, No 1 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev1iss1pp38-42

Antioxidant is an essential compound to keep man’s health due to its function as radical scavenging. Curcumin analog compounds can function as antioxidant (Sardjiman, 2000). The aim of the experiment was to find out the antioxidant activity of 2,.6-bis-(2’-furilidin)-cyclohexanone, 2,.5-bis-(2’furilidin)-cyclopentanone, and 1,.5-difuril-1.4-pentadien-3-one compounds, and the antioxidant activity of each compound against DPPH radical with IC50 parameter as well as the correlation of compounds structure’s activities against antioxidant. The antioxidant activity of curcumin analog compounds wereas tested against DPPH free radical. The test was conducted in 5 series of concentrations by adding 4.0 ml test solutions with 1.0 ml DPPH. The antioxidant activity against free radical was measured usingwith spectrophotometer at 517 nm wavelength and determined for the IC50 value. The experiment employed rutin as positive control. The result of the experiment showed that curcumin analog compounds have antioxidant activity with IC50 of rutin, 2,.6-bis-(2’-furilidin)-cyclohexanone, 2,.5-bis-(2’furilidin)-cyclopentanone, and 1,.5-difuril-1.4-pentadien-3-one as follows: 4.93 ppm, 22.73 ppm, 20.67 ppm, and 18.80 ppm respectively. The highest antioxidant activity belonged to 1,.5-difuril-1.4-pentadien-3-one compound which is 18.80 ppm . Correlation of activity structure of the 3 compounds can be seen from the log p parameter and energy space of HOMO-LUMO.Key words: Antioxidant, DPPH, Analog Curcumin

Analisis Etanol dalam Hair Tonic dan Hair Spray secara Kromatografi Gas Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 7 No 1 (2010): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Hair tonic and hair spray is a cosmetic for hair treatment. Hair tonic is a cosmetic treatment of the scalp and hair which is used after shampooing or when the scalp is clean. Hair spray is a cosmetic preparation used to strengthen temporary on hair that has been formed previously. The aim of the study was to determine the ethanol content in hair tonic and hair spray by gas chromatography. The quantitative analysis method used in this study was internal standard. The experiment began with looking for appropriate analysis. The chosen analysis condition was then used for quantitative analysis. The calibration curve equation was used to determine the ethanol content in hair tonic and hair spray samples. The results showed that the chosen analysis condition to determine the ethanol content in hair tonic and hair spray were: column temperature 50oC, injector temperature 70oC, detector temperature 100oC, and gas pressure 80 kPa. The ethanol content obtained in hair tonic sample was 15,2365% Â± 0,2475, while in hair spray sample was 17,2528% Â± 0,5765.

Analisis Timbal (Pb) dan Tembaga (Cu) dalam Produk Burger Sapi yang Beredar di Kartasura secara Spektrofotometri Serapan Atom Amanda Duta Wijaya; Endang Sri Rejeki; Reslely Harjanti
Jurnal Farmasi Indonesia Vol 8 No 2 (2011): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Beef burger is origin beef product that is milled and grounded, dashed with condiment then swirled with fat until it is mixed rolled out. Lead and copper in beef burger could be make toxicity if its rate exceed stipubting from BPOM which is for lead content may not exceed 2,0 mg/kg whereas copper may not exceed 20,0 mg/kg. The aim of the research was to know lead and copper content in beef burger products commercial in Kartasura by atomic absorption spectrophotometry. This research used 3 samples beef burger product. The sample was put in blender then put in oven at temperatur 1100 C until dry. The sampel was ashed in muffle furnace at temperatur 5500 C for5 hours. The sample was destructed with aquaregia (mixed HCl and HNO3 = 3:1) and dissolved with aquabidestillata, then analyzed by atomic absorption spectrophotometry at wavelength 283,3 nm. The result of qualitative analysis shown positive result because at condition analysisâ€™s lead and copper element all samples gave absorption. The result of quantitative analysis rate of lead in sample A, B, C successively, that was: 0,2418 Â± 0,0005 mg/kg; 0,2412 Â± 0,0006mg/kg; 0,2398 mg/kg. The result of quantitative analysis rate of copper in sample A, B, C successively, that was:0,2886 mg/kg; 0,3312 Â± 0,000001 mg/kg; 0,2956 Â± 0,0012 mg/kg.

Uji Aktivitas Antijamur Kombinasi Berbagai Tanaman terhadap Pityrosporum ovale Ismi Rahmawati; Opstaria Saptarini; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

One cause of tinea versicolor is a fungal Pityrosporum ovale which colonizes on the skin. Previous research has examined the red betel leaves, beluntas leaves and cabbage leaves as antifungal against Pityrosporum ovale. This study aims to determine the effectiveness of the above herbs in the form of single or various combinations to inhibit the growth of the fungus Pityrosporum ovale by in vitro method. The extraction method was performed by infudation on the red betel leaf powder, beluntas leaves and cabbage leaves. The results of infudation are then made in a combination of (1:1), (1:3) and (3:1). The antifungal test with dilution method was then performed on the single and the combination extract. Dilution method was performed by making a series of dilutions in concentrations of 50%, 25%, 12.5%, 6.25%, 3.13%, 1.56%, 0.78%, 0.39%, 0.19%, 0.09%. The results showed that the MKC (minimum killing concentration) of red betel leaves, beluntas leaves and cabbage leaves, combination of red betel leaves and beluntas leaves (1:1), (1:3) and (3:1), combination of red betel leaves and cabbage leaves (1:1), (1:3) and (3:1) were 50%, 25%, 25%, 25%, 12.5%, 50%, 50%, 12.5%, 25% respectively. The best combination were red betel leaves and beluntas leaves infusions with a ratio of (1:3) and the combination red betel leaves and cabbage leaves infusions with a ratio of (1:3).

Optimasi Formula Gel Buah Apel Hijau (Pyrus malus L.) sebagai Antioksidan dengan Kombinasi Basis Carbopol 940 dan Gliserin secara Simplex Lattice Design Prayoga Fery Yuniarto; Endang Sri Rejeki; Dewi Ekowati
Jurnal Farmasi Indonesia Vol 11 No 2 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Apple is suspected has an antioxidant. The use of apple fruit directly considered less practical, so that it made the gel preparations. This research was aimed to optimation by Simplex Lattice Design method to get the most optimum formula gel of apple fruit as antioxidant gel. The apple fruit was macerated. The apple fruit gel use carbopol 940 (C) and glycerin (G) with three formula, F1 (100%C), F2 (50%C: 50%G), dan F3 (100%G). Optimation gel was done based on viscosity, adhesion, and dispersive power by Simplex Lattice Design method with design- expert 8.0.6.1 program. The optimum gel was analyzed the antioxidant activity by DPPH method by probit analysis for calculate IC50 value and vitamin C was used as control. The study shown that optimum combination of carbopol 940 and gliserin as basis was carbopol 2.448 g and glycerin 2.552 g. The optimum gel of apple fruit had antioxidant activity (IC50 151,43 ppm). Storage time affected the viscosity of the gel which tends to decrease during the months of storage.

Penetapan Kadar Omega-3 Undur-Undur Laut (Emerita emeritus) dalam Bentuk Granul, Bubur, dan Mentah secara Kromatografi Gas Angelina Desio Lisarni; Endang Sri Rejeki; Suhartinah Suhartinah
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Mole crab is the coastal of biological resources are spreading quite extensive and has a high nutrient content, especially omega-3 fatty acids are good for memory. Omega-3 fatty acids consist of linolenic acid, EPA, and DHA. Mole crab is processed into a granule and instant baby puree with a variety of cooking and processing. This study aims to compare the levels of omega-3 content of granule and puree that has been cooked with mole crab raw without cooking. Mole crab that was acquired, cleaned and dried and then processed into mole crab raw, the roasted dried granule, the granule sun dried, instant puree with the addition of a mole crab, and the instant puree without addition of mole crab (placebo). Samples are extracted using soxhlet with solvents chloroform:methanol (2:1). Analysis using gas chromatography with Nitrogen gas as phases of motion. The content of omega-3 was calculated based on the relative percent and analyzed by Shapiro wilk test for normality test. The result of the experiment showed that total content of omega (linolenic acid, EPA, and DHA) extract of mole crab raw was 44,416 g/100 g, extract of granuleroasted was 52,280 g/100 g, extract of granule-sundried was 29,489 g/100 g, extract of mole crabpuree and extract of puree as a placebo was not detected of omega-3.

UJI AKTIVITAS SITOTOKSIK EKSTRAK KULIT BATANG KAYU MANIS (Cinnamomum burmannii) TERHADAP KULTUR SEL T47D Wiwin Herdwiani; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 12 No 2 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Cinnamon is plant commonly used as an aroma enhancer in cooking. Cinnamon can be used as an alternative cancer treatment. The content of cinnamon bark essential oil including, safrole, cinnamaldehyde, eugenol, tannins, flavonoids, saponins. This study aimed to examine the cytotoxic activity of ethanol extract skin cinnamon to inhibit T47D breast cancer cell activity. Ethanol extract skin cinnamon was obtained through maceration method by 96% ethanol. The content of flavonoids and cinnamaldehyde was detected by Thin Layer Chromatography (TLC). Cytotoxic test on breast cancer cells T47D used 3-[4,5-dimetilthiazol-2yl]-2,5-difeniltetrazolium bromide (MTT) method and the absorbance was read at ELISA reader. Parameter single cytotoxic test is IC50.and its cytotoxic activity was compared with doxorubicin. The result showed that ethanol extract skin cinnamon had cytotoxic effect on breast cancer T47D with IC50 71,157 Î¼g/ml. The ethanol extract skin cinnamon has the potential to be developed as a cemoprefentive agency.

Optimasi Formula Gel Ekstrak Buah Mengkudu (Morinda Citrifolia L.) Sebagai Antioksidan Dengan Metode Simplex Lattice Design Dewi Ekowati; Evie Yuliaswari; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 13 No 1 (2016): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Noni Fruit (Morinda citrifolia L.) contains polyphenols, flavonoids, saponins, which plays a role as an antioxidant. Noni fruit extract is formulated in gel dosage form for the comfortness and convenience of topical use. This research aims to obtain the optimum formula noni fruit gel which effective as an antioxidant. Gel formula was optimazed by method of Simplex Lattice Design (SLD). design-expert 8.0.6.1. Gel formula was preparated using CMC-Na base (A) and (B) Carbopol 940 so it was obtained 3 formula, i.e. F1 (100% A:0% B), F2 (50% A:50% B), F3 (0% A:100% B) and then was optimized based on physical properties of viscosity, adhesivity, power spread and the shift of viscosity. The SLD's equation was used to make the gel with the response a total of physical prop erties of the gel the most optimum. Optimum gel tested antioxidant activity by using DPPHmethod. Antioxidant activity the ï¬ maximum and operating time so the IC50 values were obtained through analysis of probit with the use of vitamin C as a comparison. The optimum formula of noni fruit extract gel obtained by SLD method was the formula contained CMC-Na 78,92% : carbopol 940 21,08% with the desirability value of 0,511. The t-test results of viscosity, power latched onto, power spread and the shift of viscosity shows no significant difference. The results demonstrated the optimum gel fruit noni had antioxidant activity with IC50 value of 92,875 ppm.

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