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All Journal Indonesian Journal of Cancer Chemoprevention Computer Science and Information Technologies
Warsito P. Taruno
Center for Medical Physics and Cancer Research Ctech Labs Edwar Technology
Biochemistry, Genetics & Molecular Biology Computer Science & IT Engineering Medicine & Pharmacology

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Antiproliferative Effect of Electric Fields on Breast Tumor Cells In Vitro and In Vivo Firman Alamsyah; Izzatun Niswah Ajrina; Fitriya Nur Annisa Dewi; Diah Iskandriati; Silvia Arin Prabandari; Warsito P. Taruno
Indonesian Journal of Cancer Chemoprevention Vol 6, No 3 (2015)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev6iss3pp71-77

Abstract

Our research focused on the antiproliferative effect of low intensity (18 Vpp) and intermediate frequency (100 KHz) electrostatic wave between two capacitive electrodes on breast tumor cells in vitro and in vivo. In vitro study has been conducted by using MCF-7 cell lines treated with external electrostatic for 24, 48, and 72 hours of treatment and the cells number were calculated during treatment by using hemocytometer and presented as Growth Inhibition (GI)% efficacy. For in vivo, we used female mice (Mus musculus) strain C3H as animal model. The mice were injected with either MCF-7 cells, mammary tumor cells from C3H donor, or NaCl 0.9% (placebo) subcutaneously into the axilla area and exposed by external electrostatic in each cage for 12 hours in 2 weeks before necropsied. The adjacent and breast tissue were collected and stained with Hematoxylin – Eosin then analyzed for histopathological profile. In vitro study revealed the number of exposed cells decreased with lower proliferation rate than the non-exposed cells. Moreover, the external electrostatic caused 28-39% growth inhibition efficacy of MCF-7 cells. After 2 weeks of exposure, placebo mice were physically normal, whereas the tumor undergone significant shrinkage of more than 67% in size. Histopathological analysis of the mammary glands indicated infiltration of macrophages into the tumor area through the blood vessel. No abnormality was found in the skin layer and mammary glands of the breast tissue of placebo mice. Here, we present new knowledge of electro-capacitive cancer therapy (ECCT) as a novel treatment modality.Keywords : ECCT, tumor, in vitro, in vivo, breast cancer cells, antiproliferative
Electro-capacitive cancer therapy using wearable electric field detector: a review Tole Sutikno; Fadlil Fadlil; Ardiansyah Ardiansyah; Warsito P. Taruno; Lina Handayani
Computer Science and Information Technologies Vol 5, No 3: November 2024
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/csit.v5i3.p292-305

Abstract

Electro-capacitive cancer therapy (ECCT), a less invasive and more targeted approach using wearable electric field detectors, is revolutionizing cancer therapy, a complex process involving traditional methods like surgery, chemotherapy, and radiation. The review aims to investigate the safety and efficacy of electric field exposure in vital organs, particularly in cancer therapy, to improve medical advancements. It will investigate the impact on cytokines and insulation integrity, as well as contribute to improving diagnostic techniques and safety measures in medical and engineering fields. Wearable electric field detectors have revolutionized cancer therapy by offering a non-invasive and personalized approach to treatment. These devices, such as smart caps or patches, measure changes in electric fields by detecting capacitance alterations. Their lightweight, comfortable, and easy to-wear nature allows for real-time monitoring, providing valuable data for personalized treatment plans. The portability of wearable detectors allows for long-term surveillance outside clinical settings, increasing therapy efficacy. The ability to collect data over extended periods provides a comprehensive view of electric field dynamics, aiding researchers in understanding tumor growth and progression. Technology advancements in electro-capacitive therapy, including wearable devices, have revolutionized cancer treatment by adjusting electric field intensity in real-time, enhancing personalized medicine, and improving treatment outcomes and patient quality of life.
Co-Authors Ardiansyah, Ardiansyah Dewi, Fitriya Nur Annisa Diah Iskandriati Fadlil Fadlil Firman Alamsyah Izzatun Niswah Ajrina Lina Handayani Silvia Arin Prabandari Tole Sutikno