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All Journal Indonesian Journal of Tropical and Infectious Disease Plexus Medical Journal
Dhani Redhono Harioputro
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Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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The Effect of C-Reactive Protein Levels, Neutrophil, and Lymphocyte Count to Mortality of COVID-19 Patients with Sepsis in Referral Hospital Malikhah, Avina Norma; Dhani Redhono Harioputro; Agung Susanto; Evi Nurhayatun
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.48634

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by infection of Severe Acute RespiratoryDistress Syndrom Coronavirus-2 (SARS CoV-2). COVID-19 patients may develop sepsis, the disregulation ofthe immune system that causes organ dysfunction and life-threatening situations. High mortality of COVID-19and sepsis make it important to study. The purpose of this study is to analyze the effect of CRP levels, neutrophil,and lymphocyte count to mortality of COVID-19 patients with sepsis. This study is an analytic observational studywith a cross-sectional approach. Samples were randomly retrieved of COVID-19 patients with sepsis admittedin referral hospital. Univariate, bivariate, and multivariate analysis used SPSS 26th version of Windows. Theresults of this study indicate a significant effect of CRP levels and neutrophil count on mortality of COVID-19patients with sepsis. Meanwhile, lymphocyte count had no significant effects. The multivariate analysis showedits significance value. Partially, the effect of neutrophils on the patient's mortality has a significant value. Theconclusion of this study is CRP levels and neutrophil count simultaneously have an effect on higher mortality ofCOVID-19 patients with sepsis.
Hubungan HbA1c dan Asam Urat dengan Derajat Keparahan Disfungsi Ereksi pada Pasien Diabetes Melitus Tipe 2 di RSUD Dr. Moewardi Surakarta Gladera Wedpavica Zealtito Zulfan; Eva Niamuzisilawati; Arifin; Dhani Redhono Harioputro
Plexus Medical Journal Vol. 4 No. 3 (2025): Juni
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v4i3.1960

Abstract

Pendahuluan: Disfungsi ereksi merupakan salah satu komplikasi tersering pada pasien diabetes melitus tipe 2 yang sering dihubungkan dengan penyakit kardiovaskular. Mendeteksi dini potensi adanya disfungsi ereksi sebagai prediktor penyakit kardiovaskular penting dilakukan. Penelitian ini bertujuan mengetahui hubungan Hemoglobin A1c dan asam urat sebagai indikator dalam memberikan gambaran keparahan disfungsi ereksi. Metode: Penelitian cross-sectional terhadap pasien laki-laki dengan diabetes melitus tpe 2 di poliklinik endokrin Rumah Sakit Umum Daerah Dr. Moewardi. 32 sampel yang memenuhi kriteria inklusi mengisi kuesioner International Index of Erectile Function (IIEF-5) sebagai klasifikasi derajat disfungsi ereksi. Data diolah menggunakan uji Rank Spearman. Hasil: Tidak terdapat hubungan yang signifikan antara keparahan disfungsi ereksi dengan Hemoglobin A1c (p>0.05 dan r=0.347) dan asam urat (p>0.05 dan r=0.140) meskipun keduanya memiliki korelasi positif. Kesimpulan: Tidak terdapat hubungan yang signifikan antara Hemoglobin A1c dan asam urat dengan derajat keparahan disfungsi ereksi.
Co-Authors Agung Susanto Arifin Eva Niamuzisilawati Evi Nurhayatun Gani Dwi Cahya Gladera Wedpavica Zealtito Zulfan Malikhah, Avina Norma Marwoto .