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All Journal Indonesian Journal of Tropical and Infectious Disease
Evi Nurhayatun
Unknown Affiliation
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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The Effect of C-Reactive Protein Levels, Neutrophil, and Lymphocyte Count to Mortality of COVID-19 Patients with Sepsis in Referral Hospital Malikhah, Avina Norma; Dhani Redhono Harioputro; Agung Susanto; Evi Nurhayatun
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 1 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i1.48634

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by infection of Severe Acute RespiratoryDistress Syndrom Coronavirus-2 (SARS CoV-2). COVID-19 patients may develop sepsis, the disregulation ofthe immune system that causes organ dysfunction and life-threatening situations. High mortality of COVID-19and sepsis make it important to study. The purpose of this study is to analyze the effect of CRP levels, neutrophil,and lymphocyte count to mortality of COVID-19 patients with sepsis. This study is an analytic observational studywith a cross-sectional approach. Samples were randomly retrieved of COVID-19 patients with sepsis admittedin referral hospital. Univariate, bivariate, and multivariate analysis used SPSS 26th version of Windows. Theresults of this study indicate a significant effect of CRP levels and neutrophil count on mortality of COVID-19patients with sepsis. Meanwhile, lymphocyte count had no significant effects. The multivariate analysis showedits significance value. Partially, the effect of neutrophils on the patient's mortality has a significant value. Theconclusion of this study is CRP levels and neutrophil count simultaneously have an effect on higher mortality ofCOVID-19 patients with sepsis.
Co-Authors Agung Susanto Dhani Redhono Harioputro Malikhah, Avina Norma