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All Journal Tropical Medicine Journal ELKHA : Jurnal Teknik Elektro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Sari Pediatri Paediatrica Indonesiana Jurnal Gizi Klinik Indonesia
Roni Naning
Department Of Pediatrics, Faculty Of Medicine, Public Health, And Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Central Java
Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

 1 
Anti-hepatitis B surface (anti-HBs) seroprotection in children with acute lymphoblastic leukemia post hepatitis B vaccination in Indonesia . Yustinah; Nenny Sri Mulyani; Roni Naning
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 01 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.908 KB) | DOI: 10.19106/JMedScie004601201402

Abstract

Children with acute lymphoblastic leukemia (ALL) receiving chemotherapy are at high risk fordeveloping hepatitis B infection. Protective effect of hepatitis B vaccination in children withALL in Indonesia has not been investigated yet. The aim of study was to determine the proportiondifference of anti-HBs seroprotection between children with ALL and without malignancy posthepatitis B vaccination. We had conducted a case-control study from January to February 2012at Dr. Sardjito General Hospital, Yogyakarta. We ascertained 1-15 years old children with ALLreceiving chemotherapy and without malignancy who had hepatitis B vaccination. Sixty sevenchildren were included in this study. Anti-HBs seroprotection level was measured using anenzyme-linked immunosorbent assay (ELISA). The results were analyzed using Chi-square test.Twenty one children (65.6%) with ALL and 13 children (37.1%) without malignancy showedanti-HBs seroprotection. The difference was statistically significant with p-value of 0.020(prevalence ratio [PR]=0.3; 95% CI=0.11-0.84). Both groups showed no significantly differenceof anti-HBs seroprotection according to either female gender, risk classification, or phase ofchemotherapy with p-value of 0.38 (PR =4; 95% CI=1.05-15.2), 0.248 (PR =3.37; 95%CI=0.58-19.6) or 0.214, respectively. In conclusion, the proportion of anti-HBs seroprotectionin children with ALL is higher than those without malignancy.
Prognostic predictor at Pediatrics Intensive Care Unit (PICU) with Pediatric Risk of Mortality III (PRISM III) scores Vita Susianawati; Purnomo Suryantoro; Roni Naning
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 02 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.94 KB) | DOI: 10.19106/JMedScie004602201403

Abstract

Various mortality prognostic scoring system are available for predicting mortality risk in PediatricIntensive Care Unit (PICU). The Pediatric Risk of Mortality III (PRISM III) scoring system is one ofthe main indicators used in the PICU. This study was conducted to evaluate the PRISM III asprognostic predictor in PICU. This was a cohort study involving 64 patients who admitted toPICU in Dr. Sardjito General Hospital, Yogyakarta and met inclusion and exclusion criteria. Theclinical state of patients were assessed and the PRISM III scores corresponding to the firs 24hours of hospitalization were calculated. Outcome analysis was defined either as death ordischarged from the hospital were recorded.Multivariateanalysiswas performed to find outindependent predictive factor that influence the outcome of death.The discriminative power ofthe model was calculated based on the receiver operator curve (ROC). The result showed thatmental status (relative risk/RR: 13.21; 95%CI: 1.18-14.80), White Blood Count/WBC (RR: 19.51;95%CI: 18.12-25.15) and Blood Urea Nitrogen/BUN (RR:22.87; 95%CI:1.85-28.20) were foundto be the main predictive factors of death in PICU. The cut off value of 51 of PRISM III scoreyielded the best sensitivity (83%) and specificity (69%). In conclusion,PRISM III score can beused as a prognostic predictor to determine the death risk ofpatients hospitalized at PICU.
Co-Authors . Yustinah Amalia Setyati Amrulloh, Yusuf Aziz Azwar Aruf Carolina Kurniawan Dibyo Pramono Diyah Rakanita Undang Dwikisworo Setyowireni Gunarti, Hesti Indah Kartika Murni Khoiriyah, Ummatul Madarina Julia Madarina Julia Mei Neni Sitaresmi Nenny Sri Mulyani Ni Kadek Nira Noormanto Noormanto Nurul Hadi Nurul Hadi, Nurul Prasetyo, Bayu Dwi Purnomo Suryantoro Rina Triasih Sasmito Nugroho Vita Susianawati