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The association of single nucleotide polymorphism (SNP) rs2922126 within ghrelin and growth hormone secretagogue receptor 1a (GHSR1a) gene with insulin resistance in obese female adolescents in Yogyakarta Special Region Madarina Julia, Cut Gina Inggriyani Rina Susilowati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 02 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Previous study reported that among 79 obese female adolescents in Yogyakarta Special Region, 44 (55.7%) of them have insulin resistance. However, no significant differences on dietary habits and physical activity between the obese female who have insulin resistance and thosewho are insulin sensitive were observed. Therefore, it was thought that genetic factors are involved in the occurrence of insulin resistance. Ghrelin and growth hormone secretagogue receptor (GHSR) genes have been associated with the insulin signaling pathway with implicationsin insulin resistance. The study aimed to analyze the association between SNP (single nucleotid polymorphism) rs2922126 in GHSR1a gene with insulin resistance in obese female adolescents in Yogyakarta Special Region. Seventy eight obese female adolescents who were selected in theprevious study were involved in this study. Secondary data including name of subjects, age, body height, body weight, BMI (body mass index), fasting glucose level, fasting insulin level, waist circumference and HOMA-IR index were obtained from previous study. Polymerase Chai Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) methods were used to the genotype analysis of SNP rs2922126. Chi-square test was used to calculate odds ratio on genotype and allele of SNP rs2922126 GHSR1a gene in insulin resistance and insulin sensitive groups. The results showed that A/A genotype individuals in SNP rs2922126 had higher risk to develop insulin resistance, compared to A/T and T/T genotypes individuals (OR: 2.03; 95%CI: 0.54-7.57). However, it was not significantly different (p>0.05). Individuals with A/A genotype and A allele carriers at SNP rs2922126 tended to have a higher value of BMI, fasting glucose level, fasting insulin level, HOMA-IR, and waist circumference compared to other carriers, althoughit was not significant (p>0.05). It can be concluded that SNP rs2922126 in GHSR1a gene is not associated with insulin resistance in obese female adolescents in Yogyakarta Special Region.Keywords: GHSR1a gene - SNP rs2922126 - insulin resistance - female - obese
Hormonal contraception as a risk factor for obesity Sugiharti, Sri; Hadi, Hamam; Julia, Madarina
Medical Journal of Indonesia Vol 14, No 3 (2005): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (197.764 KB) | DOI: 10.13181/mji.v14i3.191

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Hormonal contraception is related to change in the metabolism of some nutrients that may lead to an increase in body weight. The aims of this study is to assess the risk of obesity in hormonal contraceptive users in the District of Kulon Progo, Jogjakarta, Indonesia. A cross sectional study was used to determine the prevalence of obesity among users of contraception. A systematic cluster random sampling, using villages as clusters, was used to choose 647 users of contraception in Kulon Progo.  A hundred and two obese cases and 102 control, matched-for-age and socioeconomic status, controls were included in the case control study used to evaluate the risk of obesity among users of hormonal contraception. The prevalence of obesity among users of contraception in Kulon Progo was 15.9%. Users of hormonal contraception has a increased risk for obesity, OR: 9.4 (95% CI: 1.1 – 81.5). Users of combination pills faced the highest risk, followed by users of injected progesterone depot, while the risk in implant users was the same as that in users of non-hormonal contraception. The risk of obesity was significantly higher after 7 years of hormonal contraception use. The risk of obesity was neither related to energy intake nor expenditure. The increased risk of obesity in users of hormonal contraception was still significant after controlling for age, parity, initial weight, socioeconomic status, energy intake and expenditure, and parental obesity. We conclude that the risk of obesity is higher in users of hormonal contraception compared to the non-hormonal ones. Users of combination pills face the highest risk of obesity. (Med J Indones 2005; 14: 163-8)Keywords: hormonal contraception, family planning, obesity, case control study
Body mass index and waist-to-height ratio cut-offs as predictors of high blood pressure in adolescents Febriana, Kurnia; Nurani, Neti; Julia, Madarina
Medical Journal of Indonesia Vol 24, No 1 (2015): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2272.352 KB) | DOI: 10.13181/mji.v24i1.1200

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Background: Obesity is associated with increased risk for high blood pressure (BP). Although a routine BP measurement is indicated for all children visiting pediatric practice, recognition of children particularly at risk may save times. The aim of this study was to assess the cut-off point for body mass index (BMI) and waist-to-height ratio (WHtR) to predict high BP in adolescents. Methods: We conducted a cross-sectional study on 928 children aged 11 to 16 years in Yogyakarta. BP were measured using standard technique described by The Fourth Report on The Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. BMI was adjusted for age and sex using the WHO 2007 growth reference. WHtR was ratio of waist circumference related to height in centimeters. Receiver operating characteristic (ROC) curves were used to estimate the best cut-offs. Results: The best cut-off point for BMI-for-age Z-score (BMIZ) to predict high BP was 0.51 with sensitivity and specificity of 82% (95% CI = 78-86) and 76% (95% CI = 67-78) for systolic BP and sensitivity and specificity of 82% (95% CI = 78-86) and 72% (95% CI = 68-76) for diastolic BP. The best cut-off point for WHtR was 0.45, with sensitivity of 76% (95% CI = 67-78) and specificity of 74% (95% CI = 71-79) for systolic BP and sensitivity of 76% (95% CI = 72-80) and specificity of 70% (95% CI = 61-75) for diastolic BP.Conclusion: BMIZ of 0.51 and WHtR of 0.45 are the best cut-off point to predict high BP in adolescents.
Diabetes mellitus type 1 in congenital rubella syndrome: a case report E.S. Herini, Carina Lisa Madarina Julia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 04 (2008)
Publisher : Universitas Gadjah Mada

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Corina Lisa, Madarina Julia, E.S. Herini . Diabetes Mellitus Type 7 in Congenital Rubella SyndromeDiabetes mellitus type 1 has been reported as a very rare delayed manifestation of congenital rubella syndrome. We reported a confirmed case of congenital rubella syndrome that developed diabetes mellitus at the age of seven years. The girl had been complaining of diabetes symptoms since six months before admission, but had been misdiagnosed. The patient finally came with symptoms of diabetic ketoacidosis, a life threatening complication of diabetes mellitus. Diabetes mellitus type 1 as a delayed manifestation of congenital rubella syndrome has to be kept in mind to prevent missing the diagnosis.Key words: rubella infection - congenital rubella syndrome - diabetes mellitus type 1ABSTRAKCorina Lisa, Madarina Julia, E.S. Herini - Diabetes Mellitus Tipe 7 pada Sindroma Rubella KongenitalDiabetes melitus adalah salah satu manifestasi lambat sindrom rubella kongenital yang jarang, tetapi perlu diwaspadai. Kami melaporkan satu kasus sindrom rubela kongenital yang mengalami diabetes melitus tipe 1 pad a usia 7 tahun. Meskipun gejala diabetes telah dikeluhkan sejak enam bulan sebelum masuk rumah sakit, penyakit diabetes tetap tidak terdiagnosis. Penderita akhirnya datang dengan gejala dan tanda ketosidosis diabetikum, suatu komplikasi diabetes mellitus yang mengancam jiwa. Manifestasi lambat sindrom rubella yang berupa diabetes mellitus tipe I harus diwaspadai untuk mencegah tidak terdiagnosanya penyakit tersebut.
Wilms tumor associated with Cushing s syndrome - A case report Madarina Julia, Madarina Julia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 04 (1997)
Publisher : Universitas Gadjah Mada

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Ectopic ACTH syndrome associated with Wilms tumor is ver
Comparison of daily vs. weekly single-dose ferrous sulphate treatment in female junior high students with iron deficiency anemia Madarina Julia, Dedy Afandi, Sri Mulatsih,
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 01 (2009)
Publisher : Universitas Gadjah Mada

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Background: Complianc~ of daily treatment of iron deficiency anemia in children is still low. The compliance will be increased if the iron supplementation is given weekly. Previous study showed that there was no significant difference in the increase in hemoglobin level between daily and weekly treatment in prepubertal children. Objective: To study the difference in the increase in hemoglobin and serum ferritin levels between daily and weekly sirigle-dose treatment of ferrous sulphate in female junior high school students with iron deficiency anemia after menarche. Methods: This was a quasi-experimental study recruiting 179 and 174 anemic female students in the weekly and daily group, respectively. They receive weekly or daily single-dose of ferrous sulphate capsules. Hemoglobin levels were measured before and after the 12 weeks treatment, while serum ferritin levels were measured before and after in a subset of the study subjects. Result: Mean:t SD levels of hemoglobin before and after iron supplementation were 11.18:1: 0.51 and 12.79:t0.63 g/dl (p=0.001) in the weekly group, and 11.17:1:0.61 and 12.68:1:0.57 g/dl (p=0.001) in the daily group. Mean:l: SD levels of ferritin before and after iron supplementation were 6.95:1: 1.85 and 41.5:1:33.93 ng/ml (p=0.001) in the weekly group, and 6.61 :1:2.17 and 40.7:1:22.73 ng/ml (p=0.001) in the daily group. The prevalence of anemia after supplementation is similar in both groups, i.e. 6.7% in the weekly group and 8.0% in the daily group (p = 0.631. There were no significance difference in the occurrence of side effects of diarrhea and nausea in both groups (p>0.05). Conclusion: This study concluded that daily vs. weekly ferrous sulphate supplementation did not result in significantly different level of both hemoglobin and serum ferritin after treatment. The difference in the occurrence of side effects was also not statistically significant. Key words: anemia iron deficiency - hemoglobin level - serum ferritin level - ferrous sulphate
Hubungan Pola Asuh Keluarga dengan Kejadian Kurang Energi Protein Anak Balita Akhmadi, Akhmadi; Hadi, Hamam; Julia, Madarina
Jurnal Ilmu Keperawatan Vol 2, No 1 (2007)
Publisher : School of Nursing Faculty of Medicine Universitas Gadjah Mada

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Please refer to the file
Korelasi Tinggi Badan Ibu dengan Panjang Badan Bayi Baru Lahir di Kota Palu Lamana, Aspia; Julia, Madarina; Dasuki, Djaswadi
JURNAL KESEHATAN REPRODUKSI Vol 4, No 2 (2017)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.295 KB) | DOI: 10.22146/jkr.35419

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Background: Body length of newborn babies is related to health in adulthood. Some studies suggested that short people tend to have lower intellectual performance that can reduce working capacity, poor reproductive performance and increase risk of cardiovascular disease and type 2 diabetes. In addition, the less the body’s length of newborns the more adverse long-term health such as obesity, cardiometabolic disorders, and neuro psychiatric conditions were encountered.Objective: To determine the relation of mothers’ height with body length newborns in Palu. Samples are babies born in the first 24-72 hours of private hospitals, health centers, and maternity clinics in Palu. Method: An observational study with cross sectional design. The independent variable is the mothers’ height and the dependent variable is the length of the body of the newborns. Data collection used questionnaires. Data analysis used linear regression.Result and Discussion: There was a correlation between the height of mothers with the body length of newborns (r = 0.26) (p <0.001). There was a significant relationship between mothers’ upper arm circumference, the amount of iron preparations consumed, the height of the father (p <0.001) as well as maternal education (p <0.020) and the sex of the newborn (p <0.015) with the body length of newborns. There was no significant relationship between body length of newborns with socioeconomic status (p <0.861).Conclusion: Mothers’ height is not the main factor affecting the body length of newborns in the city of Palu. Education to newly wed couples and pregnant women about the importance of knowledge that body length of newborns is not only influenced by genetic factors but also by the maternal intake.Keywords: Mothers’ height, newborn body length
Perbedaan Pola Menyusui Bulan Pertama Ibu Melahirkan Seksio Sesarea Dibandingkan Melahirkan Normal di Rumah Sakit Sayang Bayi Nurmayani, Winda; Julia, Madarina; Prawitasari, Shinta
JURNAL KESEHATAN REPRODUKSI Vol 5, No 3 (2018)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.772 KB) | DOI: 10.22146/jkr.41414

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Background: exclusive breastfeeding should be provided until 6 months of age, but the fact proves that the pattern of breastfeeding has decreased. The pattern of the first month lactation is a critical period for the survival of the subsequent breastfeeding, so it is necessary to make efforts to maintain the duration of breastfeeding because the success of the first month breastfeeding will increase mothers’ confidence to continue breastfeeding.Objective: To determine differences in the pattern of the first month breastfeeding in mothers who gave birth by cesarean section compared to those by vaginal delivery in Rumah Sakit Sayang Bayi (Baby Friendly Hospital)Method: Type of research is comparative observational  with a prospective cohort design using a quantitative approach. The research was conducted in Baby Friendly Hospital of RSUD (General Hospital) Mataram City. Total sample 120 consisted of 60 mothers giving birth the caesarean section and 60 mothers vaginal delivery. The independent variable of giving birth by Cesarean Section and vaginal delivery, dependent variable pattern the first month of breastfeeding and external variables age, parity, employment, the incidence of antepartum and postpartum. The sampling technique using consecutive sampling. Analysis of the data used is univaribel, bivariate using Chi-square and Fisher's exact test and multivariable logistic regression and stratification testResult and Discussion: There was no significant correlation between the mode of delivery and the patterns of the first month breastfeeding by including a variable of employment with a value of OR (95% CI) = 1.6 (0.63 to 4.17) and there was a decrease in the value of OR (95% CI ) from 2.5 (1.05 to 5.94) to 1.6 (0.63 to 4.17); there was also no  significant correlation when involving the variable of the incidence of ante partum and post partum with the value of OR (95% CI) = 1.7 (0.45 to 6.26) and OR (95% CI) = 2.3 (0.96 to 5.53), respectively.Conclusion: : There is no difference patterns of breastfeeding mothers first month who gave birth cesarean section compared to normal birth. Caesarean section would affect the pattern of the first month breastfeeding if cesarean section deliveries occurred at housewives and mothers who did not experience the incidence of ante partum. Keywords: pattern of breastfeeding; vaginal deliveries; caesarean section; breast milk; 
FAKTOR YANG MEMPENGARUHI PERILAKU ORANG TUA DALAM PENCARIAN PENGOBATAN ANAK BALITA DEMAM Krisnanto, Paulinus Deny; Julia, Madarina; Lusmilasari, Lely
Jurnal Keperawatan Respati Yogyakarta Vol 3, No 2 (2016): September 2016
Publisher : Universitas Respati Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (63.67 KB) | DOI: 10.2016/jkry.v3i2.24

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 Demam merupakan tanda dan gejala dari suatu penyakit. Demam umumnya membuat kalangan orang tua menjadi takut dan fobia karena orang tua beranggapan bahwa demam merupakan penyakit yang serius. Orang tua merasa lega jika demam anak berhasil diturunkan karena beranggapan bahwa penyakit akan sembuh. Sampai saat ini penelitian yang berkaitan dengan faktor yang mempengaruhi perilaku pencarian  pengobatan pada anak demam belum dilakukan penelitian di Indonesia.  Tujuan penelitian untuk mengetahui faktor yang mempengaruhi perilaku orang tua dalam pencarian pengobatan pada anak demam di Wilayah Kerja Puskesmas Ngaglik Sleman Yogyakarta. Desain penelitian yang digunakan dalam penelitian  adalah “Cross Sectional”. Tehnik pengambilan sampel pada penelitian ini menggunakan accidental sampling dengan jumlah sampel 96 orang tua yang memiliki anak balita demam. Analisis bivariat menggunakan chi square dan analisis multivariat menggunakan regresi logistik.  Diketahui bahwa 62,5 %  orang tua berobat ketenaga kesehatan dan 37,5 % orang tua yang melakukan pengobatan ke non kesehatan ketika anak demam. Hasil analisi bivariat mendapatkan variabel yang secara signifikan berhubungan dengan perilaku pencarian pengobatan yaitu persepsi sakit, umur anak dan nasehat orang lain  dengan p value < 0,05. Analisis multivariat mendapatkan variabel yang paling mempengaruhi perilaku pencarian pengobatan yaitu persepsi sakit. Terdapat hubungan antara persepsi sakit, umur anak dan nasehat orang lain terhadap perilaku pencarian pengobatan orang tua pada anak demam, Kata Kunci: Demam, perilaku pencarian pengobatan, anak balita
Co-Authors A.A. Ketut Agung Cahyawan W Achmad Surjono Adhila Fayasari Agustini Utari Ahmad Husain Asdie Ahmad Husain Asdie Ahmad Husain Asdie Ahmad Husain Asdie Almira Sitasari Aman B Pulungan Andi Imam Arundhana Ari Tri Astuti, Ari Tri Arief Priambodo Astuti, Lucia Mawarti Dwi Attika A. Andarie Basuki, Siswanto Cerdasari, Carissa Dewi Astiti Diadra Annisa Dio Biade Djaswadi Dasuki Djauhar Ismail Ekawaty L. Haksari Emy Huriyati Endang Baliarti Endy P. Prawirohartono Endy Paryanto Prawirohartono, Endy Paryanto Eni Harmayani Esti Nurwanti Farida Wahyu Ningtyas Farida Wahyu Ningtyas Farida Wahyu Ningtyias, Farida Wahyu Fitri Haryanti Frida Soesanti Gunawan, I Made Alit H. A. Delemarre-van de Waal HA Delemarrevan de Waal Hamam Hadi Hamam Hadi Handayani Handayani Harry Freitag Luglio Muhammad Helmyati, Siti Hendratini, Julita Hizni, Alina I Made Alit Gunawan I Wayan Bikin ika agustina Indria Laksmi Gamayanti Indria Laksmi Gamayanti Irma Yunawati Joko Susilo Jufrrie, Muhammad Junaidi Junaidi Jurianto Gambir Kandarina, Bernadette Josephine Istiti Khaerul Anwar Kunayarti, Wahyuni Kurnia Febriana Laksono Trisnantoro Lamana, Aspia Legawati Legawati, Legawati Lely Lusmilasari, Lely Lisma Evareny, Mohammad Hakimi, Retna Siwi Padmawati M M van Weissenburch M. M. van Weissenbruch Mohammad Hakimi Muchtar, Mohammad Mursyid, Abidillah Neti Nurani Niken Pritayati Nina Lestari Noormanto Noormanto, Noormanto Nugroho, Akmad Kharis Nur Afia Amin Nurliyani Nurul Hadi, Nurul Nuryanti Nuryanti Pangesti, Neni Paulinus Deny Krisnanto Purnama, Ni Luh Agustini Putra, Irwansyah R. Dwi Budiningsari Rahayu, Endah Sri Rahmawati, Rahmawati Ramadhaniah, Ramadhaniah Ramli, Nurlaili Retno Sutomo Rianti Puji Lestari Rina Susilowati Riris Andono Ahmad Roni Naning Ronny Martien Ruqoyatul Himah S. Yudha Patria Santi Gunarwati Setya Wandita Shelly Puspa Anggraini Shinta Prawitasari Shoim, Mohammad Siti Nurfadilah H Slamet Rohaedi, Slamet Soeroyo Machfudz, Soeroyo Soi, Beatrix Solly Aryza Sri Mulyati Sri Sugiharti Sri Wahyuni Subardjo, Yovita Puri Sulistyaningrum, Elisa Sunartini Sunartini, Sunartini Tarigan, Noviani Titih Huriah Titih Huriah Toto Sudargo Tunjung Wibowo Tuti Nuraini Tuti Nuraini Winda Irwanti, Winda Winda Nurmayani M Yayah Lakoro Yayi Suryo Prabandari Zulfayeni, Zulfayeni