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All Journal Journal of Mathematical and Fundamental Sciences
Nanan Nur'aeny
Medical Sciences Doctoral Program, Faculty of Medicine, Universitas Padjadjaran, Jalan Professor Eyckman No.38, Bandung 40161, Jawa Barat
Astronomy Chemistry Earth & Planetary Sciences Mathematics Physics

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Serum Level of IL-6, Reactive Oxygen Species and Cortisol in Patients with Recurrent Aphthous Stomatitis related Imbalance Nutrition Intake and Atopy Nanan Nur'aeny; Dida Akhmad Gurnida; Oki Suwarsa; Irna Sufiawati
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 3 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.3.3

Abstract

One of the most common oral ulcerations is recurrent aphthous stomatitis (RAS), affecting approximately 20% of the general population worldwide. The etiology of RAS is still unclear but it is considered to be multifactorial, including imbalanced nutrition intake and allergic conditions such as atopy. The purpose of this study was to investigate the differences and correlation between the serum level of IL-6, reactive oxygen species (ROS), and cortisol in RAS patients. Our study was cross-sectional and used a consecutive sampling method. There were significant differences of IL-6 and ROS levels in all groups (p = 0.000, p = 0.049 respectively) and a significant correlation between cortisol and ROS in the RAS group without atopy (r = -0.985, p = 0.015). Serum IL-6 and ROS measurement may be used for detecting RAS caused by malnutrition or atopy but not cortisol for patients without psychological stress detected. This is consistent with the results of a very strong correlation with a negative value between cortisol and ROS in RAS without atopy.
Co-Authors Dida Akhmad Gurnida Irna Sufiawati Oki Suwarsa