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All Journal Jurnal Fisika Unand Grimsa Journal of Science Engineering and Technology
Gemi Nastiti
Jurusan Fisika FMIPA Universitas Andalas
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Earth & Planetary Sciences Electrical & Electronics Engineering Energy Engineering Materials Science & Nanotechnology Medicine & Pharmacology Physics

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In Vitro Analysis of Anti-Inflammatory Effects of Purple Chrysanthemum (Chrysanthemum morifolium) Leaf Extract Nastiti, Gemi; Fatimawali, Fatimawali; Budiarso, Fona Dwiana Hermina; Manampiring, Aaltje Ellen; Kepel, Billy Johnson; Bodhi, Widdhi
Grimsa Journal of Science Engineering and Technology Vol. 3 No. 1 (2025): April 2025
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v3i1.70

Abstract

Chronic inflammatory diseases are the most significant cause of death in the world and pose the greatest threat to human health. Treatment of inflammation is usually done by taking anti-inflammatory drugs that have dangerous side effects in long-term use. Chrysanthemum is the largest horticultural commodity in North Sulawesi that also holds great potential in the world of health. Based on its phytochemical content, purple chrysanthemum leaves have potential as an anti-inflammatory agent. This study aimed to analyze the anti-inflammatory activity of ethanol extract of purple chrysanthemum leaves using the red blood cell membrane stabilization method. This study used an in vitro laboratory experimental method using rat blood. The anti-inflammatory activity of the extract was tested using the red blood cell membrane stabilization method at 4 concentration series, namely 50 ppm, 100 ppm, 200 ppm, and 400 ppm, then measured on a UV-Vis spectrophotometer. The results of phytochemical screening showed that the ethanol extract of purple chrysanthemum (Chrysanthemum morifolium) leaves contains active compounds such as flavonoids, alkaloids, tannins, steroids, and phenolics. The ethanol extract of purple chrysanthemum leaves exhibits anti-inflammatory activity, with higher extract concentrations demonstrating stronger anti-inflammatory effects. The stability percentage values obtained at 50, 100, 200, and 400 ppm were 28.87%, 41.85%, 47.41%, and 64.15% with an IC50 of 235.88 ppm and a correlation coefficient of 0.94.
PENGARUH PROSES OKSIDASI PADA LOGAM PADUAN ZR-2,5NB UNTUK MATERIAL BIOIMPLAN Nastiti, Gemi; Handani, Sri; Bandriyana, B
Jurnal Fisika Unand Vol 3 No 4: Oktober 2014
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jfu.3.4.205-213.2014

Abstract

ABSTRAKPenelitian tentang pengaruh proses oksidasi pada logam paduan Zr-2,5Nb untuk material bioimplan telah dilakukan. Penelitian ini bertujuan untuk mengetahui stuktur mikro, kekerasan, ketahanan korosi dan toksisitas paduan logam Zr-2,5Nb sebelum dan sesudah dioksidasi. Pengujian stuktur mikro dengan mikroskop optik memperlihatkan paduan homogen berbentuk equiaxial. Proses oksidasi dilakukan menggunakan alat MSB selama 5 jam dengan variasi suhu 500ºC, 600ºC dan 700ºC. Pada oksidasi suhu 500°C tebal lapisan oksida  berkisar antara 4,06 – 5,02 µm, pada suhu 600°C tebal lapisan antara 4,20 – 7,80 µm danpada suhu 700°C tebal lapisan oksida 19,00 – 23,60 µm. Sebelum oksidasi kekerasan sebesar 233,7 VHN. Pada logam setelah dioksidasi 500°C kekerasan rata-rata sebesar 242,4 VHN. Pada oksidasi 600°C kekerasan sebesar 261,2 VHN dan 700°C kekerasan sebesar 399,1 VHN. Nilai laju korosi sebelum oksidasi sebesar 0,0695 mpy. Setelah proses oksidasi nilai korosi sampel jauh lebih rendah yaitu sebesar 0,0094 mpy. Persentasi inhibisi paduan sebelum oksidasi sebesar 13,3 % dan setelah oksidasi memiliki persentasi inhibisi sebesar 0 %, yang sangat baik  dimanfaatkan sebagai material bioimplan.Kata kunci : paduan zirkonium, oksidasi MSB, kekerasan, korosi, metode in vitro, bioimplanAbstractResearch on the effect of oxidation on the metal alloy Zr-2,5Nb for bioimplant material has been done. This research aims to find out the micro structure, hardness, corrosion resistance and toxicity of metal alloys Zr-2,5Nb before and after being oxidized. The micro structure tested by optical microscopy show a homogeneous alloy shaped equiaxial. The oxidation process is done using a MSB for 5 hours with temperature variations of 500ºC, 600ºC and 700ºC. Oxide layer thickness was measured by using SEM. At the oxidation temperature of 500°C the oxide layer thickness ranged from 4,06 to 5,02 µm, at a temperature of 600°C layer thickness between 4,20 and 7,80 µm and at temperature of 700°C the oxide layer thickness from 19,00 to 23,60 µm. Alloy hardness before oxidation  is 233,7 VHN, whereafter oxidized of 500 °C the average of metal hardness is 242,4 VHN. At 600°C oxidation the hardness is 261,2 VHN and 700°C is 399,1 VHN. Corrosion rate value before oxidation is 0,0695 mpy. After the oxidation process the corrosion rate value is much lower than before oxidation and equal to 0,0094 mpy. This is due to the presence of oxygen contained in the oxide layer. The percentage inhibition of oxidation of the alloy before oxidation is 13.3% and after oxidation is 0%, which is well used as material bioimplant.Keywords : zirconium alloys, oxidation MSB, hardness, corrosion, in vitro methods, bioimplant
Co-Authors B Bandriyana Fatimawali . Fona Budiarso Kepel, Billy Johnson Manampiring, Aaltje Ellen Sri Handani Widdhi Bodhi