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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin
Marina Rimadhani
Departemen/Staf Medik Fungsional Ilmu Kesehatan Kulit dan Kelamin Fakultas Kedokteran Universitas Airlangga/Rumah Sakit Umum Daerah Dr. Soetomo Surabaya
Immunology & microbiology Public Health

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Melanocyte Function and Count of Leukotrichia in Vitiligo Using S100 Immunohistochemistry and Microphtalmia Associated Transcription Factor (MITF) M. Yulianto Listiawan; Marina Rimadhani; Willy Sandhika
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (294.671 KB) | DOI: 10.20473/bikk.V28.3.2016.182-185

Abstract

Background: Melanocyte of the hair follicle is one of the major sources of repigmentation in vitiligo. Leukotrichia is complete depigmentation with significant bleaching hair. Leukotrichia in nonsegmental vitiligo may contribute to the lack of response to medical treatment. Leukotrichia is often associated with absent of melanocyte, showing poor prognosis for vitiligo treatment. Purpose: To evaluate melanocyte count and function of leukotrichia’s melanocyte in vitiligo and comparing with other feature. Method: Melanocyte count in each feature of lesional skin in 18 segmental vitiligo patients were evaluated based on vitiligo extent tensity index (VETI). Melanocyte count has been evaluated using immunohistochemistry S100 and microphtalmia associated transcription factor (MITF). Results: Eighteen patients were nonsegmental vitiligo, and five of them had leukotrichia. Two of five leukotrichia patients did not express MITF nor melanocyte. There were no differences of melanocyte and MITF expression between patient with or without leukotrichia. Conclusion: Leukotrichia is a poor indicator for treatment response in vitiligo, but this research showed that leucotrichia may not contribute to the lack of response upon medical treatment.
Pengaruh Hormon terhadap Akne Vulgaris Marina Rimadhani; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 27 No. 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (901.351 KB) | DOI: 10.20473/bikk.V27.3.2015.218-224

Abstract

SurabayaABSTRAKLatar belakang: Akne vulgaris (AV) merupakan salah satu kelainan kulit yang sering ditemui dalam kehidupan sehari-hari. Hormon diketahui memiliki peran penting dalam perkembangan akne, namun banyak hal yang masih belum terjawab tentang mekanisme hormon terhadap akne. Tujuan: Memberikan informasi peran hormon pada akne terutama pada kelenjar sebasea sehingga klinisi dapat memberikan edukasi dan penanganan lebih baik kepada pasien. Telaah kepustakaan: Hormon androgen yang berperan penting pada perkembangan terjadinya akne adalah dehidrotestosteron (DHT), testosteron, prekusor adrenaldehidroepiandrosteron sulfat (DHEAS), hormon lainnya seperti glukokortikoid, estrogen, progesteron, dan insulin. Simpulan: Hormon memiliki peran penting dalam pembentukan AV, namun multifaktor lainnya harus dipertimbangkan. Edukasi dan kepedulian pasien terhadap akne merupakan kunci keberhasilan terapi.
Co-Authors M. Yulianto Listiawan Rahmadewi Rahmadewi Willy Sandhika