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All Journal Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rahmadewi Rahmadewi
Department Of Dermatology And Venereology, Faculty Of Medicine Universitas Airlangga / Dr. Soetomo General Academic Hospital Surabaya
Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Perbedaan antara Uji Transformasi Limfosit dengan Uji Tempel Obat pada Pasien Erupsi Obat Karina, Dhita; Rahmadewi, Rahmadewi; Pohan, Saut Sahat
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.981 KB) | DOI: 10.20473/bikkk.V26.1.2014.1-6

Abstract

SurabayaABSTRAKLatar belakang:Diagnosis erupsi obatseringditegakkan berdasarkan anamnesis dan pemeriksaanklinis sajasehingga sulit untuk mengetahui obat penyebabnya. Pemeriksaan penunjang diperlukan untukdiagnosis yang lebih pastidan mengetahui penyebabnya. Uji Tempel Obat (UTO) adalah prosedur in vivoyang sering digunakan di praktek sehari-hari dan sensitivitasnya sebesar 30-50%. Uji Transformasi Limfosit (UTL) adalah suatu pemeriksaan laboratorium dengan prosedur invitroyangsensitivitasnya dilaporkan 70-90% dalam mendiagnosis erupsi obat. Tujuan:Menganalisis perbedaan antara hasil UTO dan UTL pada pasienerupsi obat.Metode:Penelitian cross sectionaldilakukan terhadapduapuluh dua pasien dengan riwayat erupsi obat di Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya. DilakukanUTO pada punggung pasiendanpengambilandarah venapasien untuk pemeriksaan UTL. Hasil:Dari duapuluh duapasiendidapatkan hasil positif UTO pada tujuhpasiendan negatifpada lima belaspasien, sedangkan hasil positif UTL pada dua puluh pasien dan negatif pada duapasien.Simpulan:Terdapatperbedaan yang signifikan antara UTO dan UTLpada pasien erupsi obat. Kesesuaian dua pemeriksaan ini sebesar 40,9%,yang berarti UTL dapat dilakukan bila hasil UTO negatif atau meragukan.
Increasing of Skin pH level in Childhood Atopic Dermatitis Primadiarti, Pedia; Rahmadewi, Rahmadewi; Zulkarnain, Iskandar
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (117.14 KB) | DOI: 10.20473/bikkk.V26.3.2014.1-7

Abstract

Background: Atopic dermatitis (AD) has multifactorial etiologies such as genetic, environment, and imbalance of immunology basis.  AD is marked with skin barrier dysfunction, whichcharacterized by fillagrin mutation. Fillagrin itself has an important role in skin hydration and pH adjustment, so that its functional nor amount defect will lead to hydration and pH adjustment impair, as well as shown in AD phenotype. Purpose: To evaluatethe difference of skin pH in AD (lesional and non lesional area) and normal children. Methods:  Phase 1 study was descriptive observational study, to determinenormal skin pH in 98 children. The following phase 2 was observational analitic study in 38 AD patients todeterminepH level of atopic group (lesional and non lesional skin).Results: pH level of normal children skin was 4.86±0.461, lesional skin in AD was 5.86±0.564, and in nonlesional skin was 5.20±0.460. One way ANOVA test revealed value p=0.000, post hoc analysis value was p=0.000. Conclusions: Higher pH level was observed on AD patients. Skin pH is an important factor in the pathogenesis of AD, main concern in the treatment of AD is maintaining skin pH, which is important to reduce AD exacerbation.Key words: fillagrin, pH of atopic dermatitis,pH of normal children.
Insufisiensi Adrenal Sekunder pada Eritema Nodosum Leprosum: Studi Profil TNF-α dan Kortisol Serum Citrashanty, Irmadita; Suyoso, Sunarso; Rahmadewi, Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.361 KB) | DOI: 10.20473/bikkk.V26.2.2014.1-6

Abstract

Latar belakang: Beberapa studi mengemukakan bahwa peningkatan tumor necrosis factor–alpha (TNF-α) sebanding dengan derajat keparahan Eritema Nodosum Leprosum (ENL), sehingga sitokin ini dianggap sebagai seromarker. Sekresi adrenocorticotropin hormone (ACTH) meningkat akibat pelepasan sitokin proinflamasi, kemudian ACTH akan merangsang pelepasan glukokortikoid adrenal sebagai umpan balik. Apabila rangsangan sitokin ini berlangsung kronis, korteks adrenal akan mengalami kelelahan yang berakibat menurunnya serum kortisol. Pemberian kortikosteroid eksogen jangka panjang diduga menyebabkan terjadinya penurunan kortisol. Tujuan: Mengevaluasi profil TNF-α dan kortisol serum pada pasien ENL yang diterapi kortikosteroid berdasarkan riwayat lamanya ENL. Metode: Dua puluh satu subjek dilakukan pemeriksaan fisik, anamnesis riwayat ENL, dan pengambilan sampel darah jam 08.00-09.00 untuk melihat kadar TNF-α dan kortisol serum. Hasil: Dari 21 sampel didapatkan rerata TNF-α serum sebesar 4,51 ± 1,7 ρg/mL. Rerata kortisol serum pada pasien dengan riwayat ENL 1-12 bulan sebesar 15,23 ± 2,3 μg/dL, riwayat ENL > 12-24 bulan sebesar 8,75 ± 4,8 μg/dL, dan riwayat ENL > 24-36 bulan sebesar 1,17 ± 0,7 μg/dL. Simpulan: Rerata penurunan kortisol serum tampak seiring dengan semakin lamanya pasien menderita ENL dan mendapatkan terapi kortikosteroid. Insufisiensi adrenal sekunder pada penelitian ini dapat disebabkan oleh pemberian kortikosteroid jangka panjang maupun adanya paparan sitokin proinflamasi kronis. Kata kunci: eritema nodosum leprosum, insufisiensi adrenal sekunder, kortikosteroid, TNF-α, kortisol.
StudiRetrospektif:Diagnosis dan Terapi Pasien Melasma Umborowati, Menul Ayu; Rahmadewi, Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.071 KB) | DOI: 10.20473/bikkk.V26.1.2014.1-8

Abstract

Latar belakang:Melasmaadalah penyakit yang banyak dijumpai terutama dinegara beriklim tropis seperti Indonesia. Masalah yang dihadapi adalah responsterhadap terapiyang beragam, sehingga diagnosis dan terapi yang tepat untuk penyakit ini masih perlu terus dikembangkan.Tujuan: Mengevaluasi penegakan diagnosis dan pemberian terapi melasma guna meningkatkan pelayanan terhadap pasien di masa yang akan datang. Metode:Penelitian retrospektif pasienmelasma di Divisi Kosmetik Medik Unit Rawat Jalan (URJ) Kulit dan Kelamin RSUD Dr.Soetomo Surabaya selama periode 1 Januari 2009 sampai dengan 30Desember 2011. Data diperoleh dari rekam medis.Hasil:Pasienmelasma sebanyak 14,1% dari seluruh pasienbaru Divisi Kosmetik Medik, pasienperempuan sebanyak 99,2% dengan faktor pencetus utama adalah sinar matahari. Diagnosis ditegakkan dari pemeriksaan fisik dan lampu Wood, terapi topikal yang banyak diberikan adalah tabir surya, formula Kligman, dan Alpha Hydroxy Acid(AHA).Simpulan:Metode penegakan diagnosis dan pilihan agen pemutih sebagai terapi melasma di Divisi Kosmetik Medik URJ Kulit dan Kelamin RSUD Dr.Soetomo Surabaya masih perlu dievaluasi sesuai dengan bukti dan temuanterbaru.Kata kunci:melasma, studi retrospektif, diagnosis, terapi.
Peeling Asam Glikolat pada Pasien Photoaging Primadiarti, Pedia; Rahmadewi, Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.676 KB) | DOI: 10.20473/bikkk.V26.2.2014.1-6

Abstract

Latar belakang: Penuaan kulit memiliki dua komponen, yaitu penuaan secara intrinsik dan ekstrinsik. Faktor ekstrinsik yang paling penting dalam proses penuaan adalah sinar matahari yang disebut dengan photoaging. Salah satu terapi photoaging adalah pengelupasan kimiawi dengan menggunakan asam glikolat (AG). Tujuan: Mengevaluasi gambaran, distribusi, diagnosis pasien photoaging, pelaksanaan dan hasil akhir pelaksanaan peeling AG pasien photoaging di IRJ Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya Periode 2008-2010. Metode: Studi retrospektif dari data rekam medis pada kunjungan baru pasien photoaging selama periode 2008-2010. Dicatat data dasar, diagnosis, pengobatan sebelum peeling, proses pelaksanaan peeling dan evaluasi hasil peeling. Hasil: Jumlah pasien yang menjalani peeling dengan menggunakan AG adalah 159 orang, terbanyak berumur 31-40 tahun, keluhan paling banyak adalah ingin mencerahkan kulit dan kulit kusam. Pemeriksaan fisik yang paling banyak ditemukan adalah perubahan pigmen. Interval pelaksanaan peeling sebagian besar adalah 4 minggu. Simpulan: Peeling dengan AG merupakan salah satu terapi pilihan untuk photoaging di RSUD Dr. Soetomo terutama untuk kasus photoaging Glogau 1 dan 2. Pelaksanaan yang baik dan kepatuhan pasien merupakan faktor yang menentukan hasil peeling.Kata kunci: peeling, photoaging, retrospektif.
Dermoscopic Features of Alopecia Patient Paramita, Kartika; Listiawan, M. Yulianto; Rahmadewi, Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.569 KB) | DOI: 10.20473/bikkk.V27.3.2015.163-169

Abstract

Backgroud: Alopecia is hair loss of the scalp that occurs in mostly men and about 30% of women during their lifetime. Prevalence of alopecia is increased along with age in both men and women. Using of dermoscope can help the diagnostic accuracy and avoid scalp biopsy for diagnosis. Purpose: Identifying dermoscope examination results and determine the pathophysiology of dermoscope features. Methods: Cross sectional and descriptiove observational study to all of alopecia patients who fulfilled the inclusion criteria at outpatient clinic Dr. Soetomo General Hospital Surabaya in December 2014 through February 2015 performed dermoscope examination Result: There were 20 patients who fulfilled the inclusion criteria, consisted of 3 patients with androgenetic alopecia, 8 alopecia areata, 4 tinea capitis, 2 discoid lupus erythematosus, 1 psoriasis vulgaris, 1 seborheic dermatitis, and 1 trichotilomania. Conclusion: Most of all dermoscope features accordance with the description in the literature, the most diagnosis is androgenetic alopecia.Key words: alopecia, dermoscope, zig-zag hair, black dots.
Oral Antibiotic in Acne Vulgaris Patients: Retrospective Study Rimadhani, Marina; Rahmadewi, Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.979 KB) | DOI: 10.20473/bikkk.V27.2.2015.84-89

Abstract

Background: Antibiotic resistance is one of the health problem in Indonesia, the one of the reason is using combination of antibiotic, so that clinician should prevent resistance to any selected combination antibiotic therapy. The use of long period oral antibiotics in acne therapy can cause Propionibacterium acne resistanceto antibioticsincreasedfrom 20% in 1979to67% in 1996. Purpose: To describe and evaluate management of oral antibiotic in new patient with acne vulgaris. Methods: Retrospective study in patients with acne vulgaris who received oral antibiotic in Cosmetic Division Dermato-Venereology Department Outpatient Clinic of Dr. Soetomo General Hospital in period of January 2010 to December 2012. Results: Obtained 481 new patients receive oral antibiotic from the total visit of 3519 acne vulgaris patient. The proportion of the largest group of 15-24 years, female patient were found having higher incidence than male. The most clinical feature found was grade 2 papulopustular (49.6%). The most common treatment which were given to the patient were doxycycline (98.8%) for systemic treatment with topical combination therapy as sunscreen (24.8%), facial cleansers(23.6%), tretinoin(20.99%), clindamycin gel (19.3%), and benzoylperoxide(5.4%). Highest proportion of long duration use of antibiotics is 2 weeks(57.5%). Conclusions: Selection of combination therapy is appropriate, but the use oftopical antibioticsalong withoral antibioticsshould be considered. Combination therapy, duration, and education still play an important role in preventing resistance Propionibacterium acne to antibiotics.Key words: acne vulgaris, antibiotic resistance, combination therapy, retrospective.
CLINICAL PROFILES OF VITILIGO WITH NARROWBAND UVB AND TOPICAL CORTICOSTEROID THERAPY AT DR. SOETOMO HOSPITAL Sarah Fauzia; Rahmadewi Rahmadewi; Dyah Fauziah
Jurnal Berkala Epidemiologi Vol. 8 No. 1 (2020): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V8I12020.8-15

Abstract

Background: Vitiligo is a depigmenting disorder that causes a loss of melanocytes in the epidermis. Treatment preferences are based on the characteristics of the vitiligo lesions. Purpose: This study evaluates the clinical profiles of vitiligo treated with narrowband UVB (NB-UVB) radiation and topical corticosteroid therapy in Dr. Soetomo Hospital in 2017. Methods: This study is a retrospective study that uses data from the medical records of vitiligo patients who were treated with NB-UVB radiation and topical corticosteroids in Dr. Soetomo Hospital in 2017. The dependent variable was vitiligo treated with NB-UVB radiation or topical corticosteroids, while the independent variables were disease onset, precipitating factor, duration, stability, amount, affected area, location, and type of vitiligo. Results: Thirty-seven patients (19 females) were included, four of whom had been treated with NB-UVB radiation and 33 with topical corticosteroids. In the NB-UVB radiation group, 75% had stable lesions, 50% had a single lesion, 50% had multiple lesions, 75% had an affected area <10cm2, 40% had lesions around their face, 40% had lesions on their extremities, and 75% had focal vitiligo. In the topical corticosteroids group, 75.76% had active lesions, 81.82% had multiple lesions, 81.82% had an affected area <10 cm2, 28.21% had lesions around their upper extremities, 28.21% had lesions around their lower extremities, and 45.45% had segmental vitiligo. Conclusion: Treatment preference in Dr. Soetomo Hospital 2017 was indicated by the patients’ clinical profiles.
A Retrospective Study: The Profile of New Patient with Vitiligo Nurina Dhani Rahmayanti; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.881 KB) | DOI: 10.20473/bikk.V28.2.2016.130-136

Abstract

Background: Vitiligo occurs worldwide, with prevalence of 0.1 to 2.0 percent, commonly begins in childhood or young adulthood, with peak onset of 10 to 30 years, but it may occur at any age. Based on vitiligo new patient profile, treatment and recovery of patients could be expected to be better. Purpose: To evaluate the profile of new patients with vitiligo. Methods: A restrospective descriptive study was carried out in Medical Cosmetic Division Dermatovenereology Outpatient Clinic Soetomo Hospital Surabaya in 2012-2014. Result: New patient of vitiligo in Medical Cosmetic Division Dermatology and Venereology Out Patient Clinic Soetomo Hospital Surabaya in 2012-2014 were 188, which was 0.2% of total patient. The most frequent age was 25-44 years old as much as 61 patients, and mostly woman (68.1%).  Fourty three point one percent came to out patient clinic after having vitiligo for more than 12 months. 78.5% had multiple lesions and 83.5% with lesion less than 10 cm2. Topical corticosteroid were given to 86.2%, sun block in 84%, topical oksoralen in 48.9% and cosmetic camouflage in 10.6% patient. Most of them (69.5%) never came to out patient clinic to check their disease. Conclusion: The average of vitiligo case in Soetomo Hospital Surabaya is 62 patient per year and mostly woman Key words: vitiligo, retrospective, profile.
Treatment Options for Postinflammatory Hyperpigmentation in Color Skin Putri Hendria Wardhani; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 3 (2016): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.703 KB) | DOI: 10.20473/bikk.V28.3.2016.243-250

Abstract

Background: Post inflammatory hyperpigmentation (PIH) is a reactive hypermelanosis after inflammation. PIH can have a negative impact on a patient’s quality of life, particularly for darker-skinned patient. Although PIH can occur in any skin type, but this type of hypermelanosis is more common in color skin patients. Purpose: Review treatment options for HPI in color skin. Review: Skin of color describes individuals with increased epidermal pigment and darker skin. This subset of patients has unique cosmetic concerns and often requires special consideration for cosmetic procedures. PIH is more frequent, more severe dan more evident in color skin. Conclusion: Treatment for the underlying dermatosis and sunscreens are an effective treatment. Topical treatment is effective for PIH epidermal only. Hydroquinone in combination with topical steroid, retinoid, glycolic acid, lactic acid as well as kojic acid, arbutin, ascorbic acid, soy, and niacinamide. Salicylic acid and glycolic acid chemical peeling as well as quality-switched (QS) neodymium-doped yttrium aluminum garnet (Nd: YAG) laser, QS Ruby, 1550 nm erbium fiber fractional thermolysis, and 1927 nm fractional thulium fiber shows a good efficacy for facial hyperpigmentation treatment.
Co-Authors Afif Hidayati Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Agatha Anindhita Ayu Ardhaninggar Agustina Tri Pujiastuti Alfrid Asditya Amanda Gracia Manuputty Amanda Gracia Manuputty Anggraeni, Sylvia Astindari Astindari Astindari Astindari, Astindari Bagus Haryo Kusumaputra, Bagus Haryo Bernadya Yogatri Anjuwita Budi Utomo Budiono Budiono Budiono Budiono Christina Avanti Cita Rosita Prakoeswa Cita Rosita Sigit Prakoeswa Cut Shelma Maharani Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Damayanti Dewi Kusumawati Dhita Karina, Dhita Diah Mira Indramaya Dwi Murtiastutik DYAH FAUZIAH, DYAH Endang Wahyu Fitriani Erwin Astha Triyono Esti Hendradi Eva Lydiawati Eva Lydiawati Evy Ervianti Fajrin, Farah Meriana Farah Meriana Fajrin Geani, Silvani Hari Sukanto Indah Purnamasari INDROPO AGUSNI Irma Tarida Listiyawati Irmadita Citrashanty, Irmadita Irwadi, Irfiansyah Iskandar Zulkarnain Leli Asih Linda Astari, Linda Lynoora, Eko Rianova M. Yulianto Listiawan Mappamasing, Hasnikmah Marina Rimadhani Marina Rimadhani, Marina Maya Wardiana Maya Wardiana Maya Wardiana Maylita Sari Maylita Sari, Maylita Menul Ayu Umborowati Menul Ayu Umborowati Menul Ayu Umborowati, Menul Ayu Nurina Dhani Rahmayanti Pedia Primadiarti, Pedia Pepy Dwi Endraswari, Pepy Dwi Pramitha, Riezky Januar Putri Hendria Wardhani Rebekah Setiabudi, Rebekah Retha Retha Ridha Ramadina Widiatma Riyana Noor Oktaviyanti Riyana Noor Oktaviyanti Rubianti, Marissa Astari Ryski Meilia Novarina Sarah Fauzia Saut Sahat Pohan Sawitri Sawitri Sawitri Sawitri Sawitri Sawitri SEPTIANA SEPTIANA Septiana Widyantari Sunarso Suyoso Sunarso Suyoso, Sunarso Tasya Wikassa Tengku Riza Zarzani N Trisniartami Setyaningrum Veithzal Rivai Zainal Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yusuf Wibisono