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All Journal Journal of Agromedicine and Medical Sciences NurseLine Journal
Ain Yuanita Insani
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Syzygium Samarangense Leaves Ointment Enhances Wound Healing Process Of Skin Burn Based On Collagen Ain Yuanita Insani; Mega Citra Prameswari; Novail Alif Muharrom; Toyibatul Hidayati; Arista Prima Nugrahani; Elly Nurus Sakinah
Journal of Agromedicine and Medical Sciences Vol 3 No 3 (2017)
Publisher : Faculty of Medicine, University of Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v3i3.6160

Abstract

Background: The World Health Organization (WHO) estimates the number of death in 2014 caused by burns is 265,000. Burns can caused skin damage as well as other complication problems such as dehydration, infection, and other multiple organ failures. Syzygium samarangense leaves contain flavonoids and saponins that can increase the activation of macrophages and TGF-B which is important to accelerate the process of collagen formation and wound healing process. Objective: Knowing the effect of Syzygium samarangense leaf extract on the healing process of burn based on collagen. Method: This in vivo study use true experimental design. We made burns by placing a coin that already heated in oven at 70ºC for 10 seconds. Rattus Wistar as experimental animals dividedinto 6 groups (n = 4) with details of Group A (normal), B (positive), C (negative). Groups D, E, and F were the groups that given ointment extract topically in doses of 15%, 30%, and 45% each day’s. Termination is done on day 7. Test statistics by using Anova and Kruskal Wallis. Results and discussion: From this research, Syzygium samarangense leaf extract can reduce the wound area (p <0,05) and increase the amount of collagen (p <0,05). Conclusion: Syzygium samarangense leaf extract ointment can accelerate the healing process of burns. Keywords : Burns, Syzygium samarangense Leaves ointment, Saponin, Flavonoid, Collagen
NEPHROPROTECTIVE EFFECT OF GARLIC CHIVES (Allium tuberosum) ON BUN AND CREATININE LEVELS OF WISTAR RATS INDUCED BY DOXORUBICIN Erfan Efend; Fuad Adi Prasetyo; Mudzakir Taufiqurrahman; Kiky Martha Ariesaka; Ain Yuanita Insani; Brilliant Givya Ariansari
NurseLine Journal Vol. 1 No. 2 (2016): November 2016
Publisher : Program Studi Ilmu Keperawatan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/nlj.v1i2.60086

Abstract

Cancer is the most leading disease that cause of death. Doxorubicin chemotherapy is often used in cancer treatment, because of its effectiveness. Although doxorubi cin has a positive effect for killing cancer cell, doxorubicin has many side effects, one of which doxorubicin can cause kidney damage through the process of inter stitial fibrosis. Utilization garlic chives ex-tract as co chemotherapy to reduce renal damage induced by doxorubicin is a prospective opportunities. This study aimed toanalyze the effect of garlic chives extract as a nephropro-tective on levels of BUN and creatinine of wistar rats induced by doxorubicin. The research method was quasi experimental design with post test only randomized controlled group. Theresults showed that extracts of garlic chives can reduce levels of BUN and creati nine (p <0.05) in the group that only induced by doxorubicin. In conclusion, ex tract of garlic chives has nephroprotecive effects on wistar rats which were in duced by doxorubicin
Co-Authors Arista Prima Nugrahani Brilliant Givya Ariansari Elly Nurus Sakinah, Elly Nurus Erfan Efend Fuad Adi Prasetyo Kiky Martha Ariesaka Mega Citra Prameswari Mudzakir Taufiqurrahman Novail Alif Muharrom Toyibatul Hidayati