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The Influence of Gestational Age and Birth Weight on Neonatal Mortality Wedi Iskandar; Yeni Andayani; Lia Marlia; Burhan Burhan; Aris Primadi
Global Medical & Health Communication (GMHC) Vol 8, No 3 (2020)
Publisher : Universitas Islam Bandung

Prematurity and low birth weight are some of the causes of neonatal death and significant health problem. This study aimed to determine the influence of gestational age and birth weight on neonatal mortality at the Al Islam Hospital Bandung in 2015–2019. It was a case-control retrospective observational analysis using medical records of the Al Islam Bandung Hospital from January 1, 2015, to December 31, 2019. The inclusion criteria for infants were born alive. Exclusion criteria had severe congenital abnormalities and gestational age <26 weeks. The chi-square test evaluated the univariate comparison test of risk factors between 2 groups. Multiple logistic regression to assess neonatal mortality's predictive factors and the percentage contribution of the influence was calculated (Nagelkerke’s R2 analysis). The number of infants enrolled in 2015–2019 was 6,791 neonates, and who died was 56 neonates (0.82%). In premature infants and low birth weight there was a very significant relationship with neonatal mortality, respectively p=0.000 (p<0.05) OR=30.397 (CI=16.506–55.976), and p=0.000 (p<0.05) OR=41.206 (CI=18.611–91.233). In the multiple logistic regression test, p=0.000 (p<0.05), with a Nagelkerke’s R2 value of 0.344 or 34.4%. This presence that gestational age and birth weight significantly affects neonatal mortality, either partially or simultaneously. The percentage contribution of the influence of gestational age and birth weight to neonatal mortality was 34.4%. PENGARUH USIA GESTASI DAN BERAT BADAN LAHIR TERHADAP KEMATIAN NEONATUSPrematuritas dan berat badan lahir rendah merupakan beberapa penyebab kematian neonatus dan masalah kesehatan yang signifikan. Penelitian ini bertujuan mengetahui pengaruh usia gestasi dan berat badan lahir terhadap kematian neonatus di RS Al Islam Bandung tahun 2015–2019. Penelitian ini merupakan penelitian observasional retrospektif kasus kontrol menggunakan data rekam medis RS Al Islam Bandung periode 1 Januari 2015 hingga 31 Desember 2019. Kriteria inklusi bayi lahir hidup. Kriteria eksklusi bayi dengan kelainan kongenital berat dan usia gestasi <26 minggu. Uji chi-square mengevaluasi perbandingan univariat faktor risiko antara 2 grup. Regresi logistik multipel untuk mengevaluasi faktor prediktif kematian neonatus dan persentase kontribusi pengaruh dihitung (Analisis R2 Nagelkerke). Jumlah bayi yang dirawat tahun 2015–2019 sebanyak 6.791 dan yang meninggal sebanyak 56 (0,82%). Pada bayi lahir prematur dan berat badan lahir rendah terdapat hubungan sangat bermakna terhadap kematian neonatus, berturut-turut p=0,000 (p<0,05) OR=30,397 (CI=16,506–55,976) dan p=0,000 (p<0,05) OR=41,206 (CI=18,611–91,233). Pada uji regresi logistik multipel, p=0,000 (p<0,05) dengan nilai R2 Nagelkerke sebesar 0,344 atau 34,4%. Usia gestasi dan berat badan lahir berpengaruh bermakna terhadap kematian neonatus, baik secara parsial maupun simultan. Persentase sumbangan pengaruh usia gestasi dan berat badan lahir terhadap kematian neonatus sebesar 34,4%.

Systematic Review: Perbandingan Efektivitas Pemberian Terapi Ivermektin dengan Permetrin pada Pengobatan Skabies Rifa Meidina; Ratna Dewi Indi Astuti; Wedi Iskandar
Jurnal Integrasi Kesehatan dan Sains Vol 3, No 2 (2021): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v3i2.7307

Skabies merupakan penyakit kulit oleh tungau Sarcoptes scabiei, penyakit ketiga paling sering di Indonesia. Pengobatan lini pertama yang direkomendasikan adalah krim permetrin 5% dan pengobatan lain menurut Centers for Disease Control and Prevention (CDC) adalah ivermektin oral dengan dosis 200 mcg/kgBB, dua dosis 14 hari terpisah. Penelitian ini bertujuan meneliti efektivitas pengobatan ivermektin oral dengan krim permetrin untuk pengobatan skabies. Metode yang digunakan adalah systematic review dengan mengevaluasi artikel publikasi ilmiah dengan desain randomized controlled trial sesuai kriteria inklusi dengan intervensi pemberian permetrin dan pembanding ivermektin serta dilakukan skrining menggunakan kriteria kelayakan. Hasil yang didapat, tiga artikel jurnal mengenai efektivitas ivermektin dan permetrin, yaitu dosis tunggal ivermektin memberikan tingkat kesembuhan pada interval dua minggu. Terapi dua aplikasi permetrin dengan interval satu minggu memiliki nilai efektif yang tinggi pada pasien. Empat jurnal menyatakan bahwa permetrin lebih unggul dalam penatalaksanaan skabies. Permetrin 5% topikal menunjukkan perbaikan lebih cepat pada minggu pertama follow-up. Satu artikel jurnal menyatakan bahwa aplikasi ivermektin sama efektifnya dengan dua aplikasi krim permetrin 2,5% follow-up 2 minggu. Setelah mengulangi pengobatan, ivermektin sama efektifnya dengan krim permetrin 2,5%. Simpulan, pemberian keduanya dapat mengobati skabies. Aplikasi permetrin dua kali dengan interval satu minggu dinilai lebih efektif daripada ivermektin dosis tunggal dan pasien sembuh lebih awal. Dua dosis ivermektin sama efektifnya dengan aplikasi tunggal permetrin. SYSTEMATIC REVIEW: THE EFFECTIVENESS OF THERAPY COMPARISON BETWEEN IVERMECTIN AND PERMETHRIN THERAPY IN SCABIES TREATMENTScabies is a skin disease caused by the mite Sarcoptes scabiei and is the third most common disease in Indonesia. The recommended first-line treatment is 5% permethrin cream, and another treatment according to the Centers for Disease Control and Prevention (CDC) is oral ivermectin at a dose of 200 mcg/kg body weight, two doses 14 days apart. This study aimed to investigate the effectiveness of oral ivermectin treatment with permethrin cream for scabies treatment. The method used is a systematic review with a randomized control trial research design by the inclusion criteria and screening using the eligibility criteria. The results obtained: three journal articles regarding the effectiveness of ivermectin and permethrin, namely a single dose of ivermectin provided a cure rate at two-week intervals, two applications of permethrin at one-week intervals have a high effectiveness value in patients; four journal articles stated that topical 5% permethrin showed faster improvement in the first week of follow-up; and one journal article state that ivermectin application was as effective as of two applications of 2.5% permethrin cream at two-weeks follow-up. After repeating the treatment, ivermectin is as effective as 2.5% permethrin cream. The conclusion is that giving both can cure scabies. Twice application of permethrin at one-week intervals was considered more effective than single-dose ivermectin, and the patient recovered earlier. Two doses of ivermectin are as effective as a single application of permethrin.

Hubungan Prematuritas dengan Keterlambatan Bicara pada Anak Usia Dua sampai Lima Tahun Farras Oktavidya Duwandani; Wedi Iskandar
Jurnal Riset Kedokteran Volume 2, No.1, Juli 2022, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Abstract. Prematurity can affect brain development processes, resulting in behavioral and cognitive changes in speech and language development. Speech delay are the most common developmental disorder in children and can be detected at the age of two to five years, which is the golden period of child development. The aim of this study was to analyze the relationship between prematurity and speech delay in children aged two to five years. This study uses a scoping review by searching for articles from PubMed, Science Direct, and SpringerLink. In the initial search, 1,229 articles were found. There were 479 articles that met the inclusion criteria, and 750 articles were excluded. The final results of the feasibility test and critical review based on PICOS and the eligibility criteria were obtained for six articles. This research was carried out between February and December of 2021. The results of the study and analysis of five articles stated that there was a correlation in children with a history of preterm birth, either from the category of moderate-to-late preterm (birth at 32 to 36 weeks) or very preterm (birth at 25 to 31 weeks), who are at risk for language performance, consisting of a less expressive vocabulary than children with a history of full-term birth. Based on this study, it can be concluded that prematurity can increase the risk of speech delay in children aged two to five years. Abstrak. Kelahiran prematur dapat mempengaruhi proses perkembangan otak yang mengakibatkan perubahan perilaku dan kognitif dalam perkembangan ucapan dan bahasa. Keterlambatan bicara merupakan gangguan perkembangan yang paling umum pada anak-anak dan dapat dideteksi pada usia dua sampai lima tahun yang merupakan periode emas perkembangan anak. Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara prematuritas dengan keterlambatan bicara pada anak usia dua sampai lima tahun. Penelitian ini menggunakan scoping review, dengan pencarian artikel yang berasal dari database PubMed, Science Direct, dan Springer Link. Pada pencarian awal didapatkan sebanyak 1.229 artikel. Terdapat 479 artikel yang sesuai dengan kriteria inklusi, dan terdapat 750 artikel yang dieksklusi. Hasil akhir uji kelayakan dan telaah kritis berdasarkan PICOS dan kriteria kelayakan didapatkan lima artikel. Penelitian ini dilakukan pada periode Februari sampai dengan Desember 2021. Hasil telaah dan analisis dari lima artikel menyatakan terdapat kolerasi pada anak prematur dari kategori moderate to late preterm (kelahiran pada 32 sampai 36 minggu) dan very preterm (kelahiran pada 25 sampai 31 minggu) memiliki risiko mengalami keterlambatan kinerja bahasa yang terdiri dari kosakata yang kurang ekspresif dibandingkan anak dengan riwayat lahir cukup bulan. Pada penelitian ini dapat disimpulkan bahwa prematuritas dapat meningkatkan risiko terjadinya keterlambatan bicara pada anak usia dua sampai lima tahun.

Scoping Review: Hubungan Suplementasi Vitamin D dengan Pencegahan dan Pengobatan Tuberkulosis pada Anak Alma Yulistia Fadhilah; Herry Garna; Wedi Iskandar
Bandung Conference Series: Medical Science Vol. 3 No. 1 (2023): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v3i1.6599

Abstract. Tuberculosis (TB) is an airborne infectious disease caused by the bacterium Mycobacterium tuberculosis which affects humans and is the leading cause of death worldwide. In cases of children with TB, there are twenty-two countries with high boundries countries ranging 3–25% of cases. Vitamin D supplements can be given as a support for the prevention and treatment of TB. The purpose of this study was to assess the relationship between vitamin D supplementation with the prevention and treatment of tuberculosis in children based on research in the last 10 years. This study uses a scoping review study. The databases used are Pubmed, ScienceDirect, SpringerLink, and ProQuest. Search for selected articles in 2012–2022 using a randomized controlled trial (RCT) research design. From 9,570 articles filtered based on the inclusion criteria, there were 657 articles, then followed by filtering the exclusion criteria, 637 articles were obtained and there were 18 duplications of 18 articles so that there were 2 articles that met the eligibility criteria based on PICOS. The results in one of the articles stated that vitamin D supplementation did not significantly prevent the risk of tuberculosis infection and in one of the articles showed that vitamin D supplementation had an effect on the resolution of fever and cough. In conclusion, serum levels of vitamin D {25(OH)D} had an effect on the resolution of fever and cough but did not prevent the risk of tuberculosis. Abstrak. Tuberkulosis (TB) merupakan penyakit menular melalui udara yang disebabkan oleh bakteri Mycobacterium tuberculosis yang memengaruhi manusia dan penyebab utama kematian di seluruh dunia. Pada kasus anak dengan TB terdapat duapuluh dua negara dengan high boundries countries berkisar 3–25% kasus. Suplemen vitamin D dapat diberikan sebagai penunjang untuk pencegahan dan pengobatan TB. Tujuan penelitian ini adalah menilai bagaimana hubungan suplementasi vitamin D dengan pencegahan dan pengobatan tuberkulosis pada anak berdasarkan penelitian pada 10 tahun terakhir. Penelitian ini menggunakan studi scoping review. Database yang digunakan, yaitu Pubmed, ScienceDirect, SpringerLink, dan ProQuest. Pencarian artikel yang dipilih tahun 2012–2022 dengan desain penelitian randomized controlled trial (RCT). Dari 9,570 artikel dilakukan filtrasi berdasar atas kriteria inklusi terdapat 657 artikel, kemudian dilanjutkan dengan filtrasi kriteria eksklusi didapatkan 637 artikel dan terdapat duplikasi sebanyak 18 artikel sehingga artikel yang memenuhi kriteria kelayakan berdasar atas PICOS adalah 2 artikel. Hasil pada salah satu artikel menyatakan bahwa suplementasi vitamin D tidak signifikan mencegah risiko infeksi TB dan satu artikel lainnya menunjukkan bahwa suplementasi vitamin D berpengaruh terhadap resolusi demam dan batuk. Simpulan, kadar vitamin D {25(OH)D} serum berpengaruh terhadap resolusi demam dan batuk, tetapi tidak mencegah risiko tuberkulosis.

Risk factors of immature retina on the first screening for retinopathy of prematurity Wedi Iskandar Kartamihardja; Gilang Mutiara; Yanuar Zulkifli Harun; Maulya Listrianti; Bestari Yuniah; Mayasari Kuntoyo
Paediatrica Indonesiana Vol 63 No 3 (2023): May 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.3.2023.189-94

Background Immature retina is characterized by peripheral retinal avascularity. Retinal development is influenced by risk factors that affect retinal maturity. Objective To identify risk factors for immature retina on the first retinopathy of prematurity (ROP) screening at the Neonatology Care Unit, Al-Islam Hospital, Bandung, in 2013-2021. Methods This case-control, retrospective, observational study was performed by evaluating medical records of preterm infants screened for ROP. The subjects were divided into two groups, immature retina and mature retina. We recorded potential risk factors including gestational age (GA), birth weight (BW), birth weight for gestational age, respiratory distress syndrome (RDS), oxygen therapy >7 days, asphyxia, sepsis, multiple transfusion, apnea of prematurity (AOP), patent ductus arteriosus (PDA), and bronchopulmonary dysplasia (BPD) and analyzed them for potential associations with retinal development. Results On the first ROP screening of 203 premature infants, 5 (2.5%) had ROP, 90 (44.6%) had immature retinas, and 107 (53.0%) had mature retinas. Bivariate logistic regression analysis showed significant relationships between immature retina (P<0.05), GA (OR=0.575; P=0.000), BW (OR=0.997; P=<0.001), gestational age maturity (OR=2.639; P=0.006), RDS (OR=1.809; P=0.042), oxygen therapy of >7 days (OR=4.494; P=0.002), sepsis (OR=2.028; P=0.034), multiple transfusions (OR=4.656; P=0.000), AOP (OR=2.553; P=0.002), PDA (OR=2.119; P=0.030). Multivariate regression analysis revealed a significant simultaneous relationship between all the risk factors and immature retina, with a NÃ¤gelkerke R2 value of 0.421. Conclusion GA, BW, gestational age maturity, oxygen therapy of >7 days, sepsis, multiple transfusions, AOP, and PDA are significant risk factors of immature retina, be it independently or simultaneously.

Hubungan Suplementasi Vitamin D dengan Pencegahan dan Pengobatan Tuberkulosis pada Anak Alma Yulistia Fadhilah; Herry Garna; Wedi Iskandar
Jurnal Riset Kedokteran Volume 3, No.1, Juli 2023, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.vi.1940

Abstract. Tuberculosis (TB) is an airborne infectious disease caused by the bacterium Mycobacterium tuberculosis which affects humans and is the leading cause of death worldwide. In cases of children with TB, there are twenty-two countries with high boundries countries ranging 3–25% of cases. Vitamin D supplements can be given as a support for the prevention and treatment of TB. The purpose of this study was to assess the relationship between vitamin D supplementation with the prevention and treatment of tuberculosis in children based on research in the last 10 years. This study uses a scoping review study. The databases used are Pubmed, ScienceDirect, SpringerLink, and ProQuest. Search for selected articles in 2012–2022 using a randomized controlled trial (RCT) research design. From 9,570 articles filtered based on the inclusion criteria, there were 657 articles, then followed by filtering the exclusion criteria, 637 articles were obtained and there were 18 duplications of 18 articles so that there were 2 articles that met the eligibility criteria based on PICOS. The results in one of the articles stated that vitamin D supplementation did not significantly prevent the risk of tuberculosis infection and in one of the articles showed that vitamin D supplementation had an effect on the resolution of fever and cough. In conclusion, serum levels of vitamin D {25(OH)D} had an effect on the resolution of fever and cough but did not prevent the risk of tuberculosis. Abstrak. Tuberkulosis (TB) merupakan penyakit menular melalui udara yang disebabkan oleh bakteri Mycobacterium tuberculosis yang memengaruhi manusia dan penyebab utama kematian di seluruh dunia. Pada kasus anak dengan TB terdapat duapuluh dua negara dengan high boundries countries berkisar 3–25% kasus. Suplemen vitamin D dapat diberikan sebagai penunjang untuk pencegahan dan pengobatan TB. Tujuan penelitian ini adalah menilai bagaimana hubungan suplementasi vitamin D dengan pencegahan dan pengobatan tuberkulosis pada anak berdasarkan penelitian pada 10 tahun terakhir. Penelitian ini menggunakan studi scoping review. Database yang digunakan, yaitu Pubmed, ScienceDirect, SpringerLink, dan ProQuest. Pencarian artikel yang dipilih tahun 2012–2022 dengan desain penelitian randomized controlled trial (RCT). Dari 9,570 artikel dilakukan filtrasi berdasar atas kriteria inklusi terdapat 657 artikel, kemudian dilanjutkan dengan filtrasi kriteria eksklusi didapatkan 637 artikel dan terdapat duplikasi sebanyak 18 artikel sehingga artikel yang memenuhi kriteria kelayakan berdasar atas PICOS adalah 2 artikel. Hasil pada salah satu artikel menyatakan bahwa suplementasi vitamin D tidak signifikan mencegah risiko infeksi TB dan satu artikel lainnya menunjukkan bahwa suplementasi vitamin D berpengaruh terhadap resolusi demam dan batuk. Simpulan, kadar vitamin D {25(OH)D} serum berpengaruh terhadap resolusi demam dan batuk, tetapi tidak mencegah risiko tuberkulosis.

Hubungan Suplementasi Vitamin D dengan Pencegahan dan Pengobatan Tuberkulosis pada Anak Alma Yulistia Fadhilah; Herry Garna; Wedi Iskandar
Jurnal Riset Kedokteran Volume 3, No.1, Juli 2023, Jurnal Riset Kedokteran (JRK)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrk.vi.1940

Abstract. Tuberculosis (TB) is an airborne infectious disease caused by the bacterium Mycobacterium tuberculosis which affects humans and is the leading cause of death worldwide. In cases of children with TB, there are twenty-two countries with high boundries countries ranging 3–25% of cases. Vitamin D supplements can be given as a support for the prevention and treatment of TB. The purpose of this study was to assess the relationship between vitamin D supplementation with the prevention and treatment of tuberculosis in children based on research in the last 10 years. This study uses a scoping review study. The databases used are Pubmed, ScienceDirect, SpringerLink, and ProQuest. Search for selected articles in 2012–2022 using a randomized controlled trial (RCT) research design. From 9,570 articles filtered based on the inclusion criteria, there were 657 articles, then followed by filtering the exclusion criteria, 637 articles were obtained and there were 18 duplications of 18 articles so that there were 2 articles that met the eligibility criteria based on PICOS. The results in one of the articles stated that vitamin D supplementation did not significantly prevent the risk of tuberculosis infection and in one of the articles showed that vitamin D supplementation had an effect on the resolution of fever and cough. In conclusion, serum levels of vitamin D {25(OH)D} had an effect on the resolution of fever and cough but did not prevent the risk of tuberculosis. Abstrak. Tuberkulosis (TB) merupakan penyakit menular melalui udara yang disebabkan oleh bakteri Mycobacterium tuberculosis yang memengaruhi manusia dan penyebab utama kematian di seluruh dunia. Pada kasus anak dengan TB terdapat duapuluh dua negara dengan high boundries countries berkisar 3–25% kasus. Suplemen vitamin D dapat diberikan sebagai penunjang untuk pencegahan dan pengobatan TB. Tujuan penelitian ini adalah menilai bagaimana hubungan suplementasi vitamin D dengan pencegahan dan pengobatan tuberkulosis pada anak berdasarkan penelitian pada 10 tahun terakhir. Penelitian ini menggunakan studi scoping review. Database yang digunakan, yaitu Pubmed, ScienceDirect, SpringerLink, dan ProQuest. Pencarian artikel yang dipilih tahun 2012–2022 dengan desain penelitian randomized controlled trial (RCT). Dari 9,570 artikel dilakukan filtrasi berdasar atas kriteria inklusi terdapat 657 artikel, kemudian dilanjutkan dengan filtrasi kriteria eksklusi didapatkan 637 artikel dan terdapat duplikasi sebanyak 18 artikel sehingga artikel yang memenuhi kriteria kelayakan berdasar atas PICOS adalah 2 artikel. Hasil pada salah satu artikel menyatakan bahwa suplementasi vitamin D tidak signifikan mencegah risiko infeksi TB dan satu artikel lainnya menunjukkan bahwa suplementasi vitamin D berpengaruh terhadap resolusi demam dan batuk. Simpulan, kadar vitamin D {25(OH)D} serum berpengaruh terhadap resolusi demam dan batuk, tetapi tidak mencegah risiko tuberkulosis.

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