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Journal : Buletin Farmatera

EFFECTIVENESS OF PREEMPTIVE ANALGESIA IBUPROFEN 10 MG / KGBB PER ORAL FOR POSTOPERATIVE PAIN MANAGEMENT IN CHILDREN UNDERGOING MASS CIRCUMCISION Muhammad Jalaluddin Assuyuthi Chalil
Buletin Farmatera Vol 4, No 3 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.03 KB) | DOI: 10.30596/bf.v4i3.2565

Abstract

Management of post-mass circumcision pain is often overlooked and not optimal because the administration of analgesia will be given when circumcision is complete. This study aims to determine the effectiveness of oral 10 mg / KGBB ibuprofen as preemptive analgesia for the management of post mass circumcision pain. After obtaining permission from the ethics commission of the FK UMSU clinical research, a prospective double-blind randomized controlled clinical trial was conducted on 28 children in consecutive sampling who met the inclusion and exclusion criteria. Samples were randomized into 2 groups, A was given ibuprofen 10 mg/kg BW orally 1 hour before incision and B was given ibuprofen 10 mg/kg BW orally at the time immediately after the circumcision was completed. Pain scale measurements were performed using FPR-S (Faces Pain Scale-Revised) at the 1st, 2nd, 4th, 6th and 8th postoperative hours. Monitoring of the 1st to 4th hours is carried out at the location of the activity, while the 6th to 8th hours are carried out by telephone. There was a significant decrease in pain scale at the 1st hour (p = 0.031) in group A. At the second to eighth-hour monitoring, the effectiveness of the two methods was the same. In conclusion, the method of preemptive analgesia is effective for the management of post-mass circumcision pain.Keywords: preemptive analgesia, post-circumcision pain
Abdominal Compartment Syndrome Muhammad Jalaluddin Assuyuthi Chalil
Buletin Farmatera Vol 2, No 1 (2017)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.891 KB) | DOI: 10.30596/bf.v2i1.890

Abstract

Abstrak: Insiden dan penyebab Intra-abdominal Hypertension (IAH) dan Abdominal Compartment Syndrome (ACS) adalah penyakit-penyakit yang berkaitan dengan penyakit kritis. Dilaporkan bahwa insiden IAH dan ACS pada populasi yang dirawat pada Intensive Care Unit (ICU) gabungan masing-masing sekitar 32,1% dan 4,2%. Laju kejadian IAH juga telah dilaporkan pada pasien-pasien dengan luka bakar berat yaitu 36,7-70%, 2%-50% pada pasien trauma berat, dan 31,5%-40,7% pada pasien yang menjalani operasi abdominal mayor. ACS meningkatkan risiko terjadinya Acute Respiratory Distress Syndrome (ARDS) dan Multiple Organ Failure (MOF) sebesar 40%, dengan laju mortalitas 63-72%. ACS didefinisikan sebagai suatu keadaan dimana Intra-Abdominal Pressure (IAP) yang bertahan> 20 mmHg (dengan atau tanpa Abdominal Perfusion Pressure (APP) < 60 mmHg) yang dikaitkan dengan terjadinya disfungsi atau kegagalan organ. ACS primer terjadi akibat adanya cedera langsung pada regio abdomen dan pelvik, sedangkan ACS sekunder terjadi tanpa adanya cedera atau kelainan langsung pada abdomen sepertipada syok berat, pemberian cairan yang masif akibat perdarahan, sepsis, capillary leak, atau luka bakar hebat. Metode pengukuran tekanan bladder dikatakan sebagai baku emas dan merupakan pengukuran yang paling dapat dipercaya. Dengan menggunakan sebuah  manometer atau transduser tekanan dan monitor, maka tekanan intravesikal dapat diukur dan dapat digunakan sebagai refleksi IAP.Kata kunci: Abdominal Compartment Syndrome, Intra Abdominal Pressure  Abdominal Compartment SyndromeAbstract:Incidence and cause IAH and ACS are diseases related to critical illness. The reported incidence of IAH and ACS is about 32.1% and 4.2%, respectively, in the mixed intensive care unit (ICU) population. Rates of IAH have also been reported for patients with severe burns (36.7%–70%) and traumatic injuries (2%–50%), and for patients who had major abdominal procedures (31.5%–40.7%). ACS increases the risk of acuterespiratory distress syndrome/multiorgan failure by 40%, mortalityassociated with abdominal compartment syndromeis 63–72%. ACS is defined as a sustained IAP > 20 mmHg (with or without an APP < 60 mmHg) that is associated with new organ dysfunction/ failure. Primary ACS results from direct injury within the abdomen and pelvic region. Secondary ACS develops without direct abdominalinjuries or conditions.Secondary ACS can be seenin patients with severe shock and who have requiredmassive fluid loading due to haemorrhage, sepsis,capillary leak, or major burns.The bladder pressure method is described as the gold standard and is the most reliable measurementof IAP via indirect means.With the use of a manometer or monitoring equipmenta pressure measurement can be achieved toestablish a reflection of IAP.Keyword: Abdominal Compartment Syndrome, Intra Abdominal Pressure