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Journal : Molucca Medica

AN OVERVIEW ABOUT THE USE OF ANTIBIOTIC IN PREGNANCY AND NURSING MOTHER IN MAKASSAR Darmawansyih Darmawansyih; Nadyah Haruna
Molucca Medica VOLUME 10, NOMOR 2, OKTOBER 2017
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.748 KB) | DOI: 10.30598/molmed.2017.v10.i2.102

Abstract

Introduction. Pregnancy is a physiological process that needs to be well prepared due to the correlation from mother and the fetus. By the same token nursing is also alike that all the substances which consumed by the mother will get in to fetal circulation. It can be denied that the condition in our community drug consumption on pregnancies women and nursing whom use drugs and supplements during the period of organogenesis progress will give a high risk of fetal defects and adverse impact to their baby. Aims. For that reasons the aim of this study is to describe the use of antibiotics in pregnancy and nursing mother in the Pertiwi Maternal and Child’s Hospital, Makassar 2014. Methods. This study was descriptive that involve all pregnancies and nursing mothers who use antibiotic are the population. Total sampling as much as 32 pregnancies and 329 nursing mothers who used antibiotics taken from Pertiwi Maternal and Child’s Hospital. Result. Some principal findings from this study are first during pregnancy the main cause that made the pregnancies used antibiotics depending on the illness experienced. Another finding is the most antibiotics that used by the pregnancies are Amoxicillin, Ampicillin and Cefadroxil where some of them bought it by their self without prescription. Another crucial finding is 329 nursing mothers use amoxicillin because of the rupture of the perineum without sensibility test before. Conclusion. This study can be drawn principal that antibiotics are the most widely used and safest when compared with other antibiotics is amoxicillin and ampicillin from the penicillin group. Another conclusion that can be drawn is the use of antibiotics during pregnancy should take into consideration several aspects, circumstances or maternal disease and the possibility of teratogenic drugs.
PENGARUH PEMBERIAN MADU TERHADAP KADAR KOLESTEROL MENCIT (Mus musculus) DENGAN SALMONELLA TYPHI Firda Ayuningsi Umamit; Nadyah Haruna; Darmawansyih Darmawansyih
Molucca Medica VOLUME 14, NOMOR 1, APRIL 2021
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (359.949 KB) | DOI: 10.30598/molmed.2021.v14.i1.70

Abstract

Senyawa antioksidan pada madu dapat menurunkan kadar kolesterol darah dengan menghambat ACAT2, mengaktifasi reseptor LDL, dan CYP7A1. Madu dapat mengontrol kadar glukosa darah melalui komponen melittin dan fosfolipasi A2, polipeptida dan enzim yang dapat meningkatkan sekresi insulin. Selain itu, madu juga dapat bertindak sebagai inihibitor enzim xantin oksidase sehingga menghambat aktivitas xantin oksidase pada produksi asam urat. Tujuan penelitian ini untuk mengetahui pengaruh pemberian madu pada kadar kolesterol, glukosa darah, dan asam urat mencit (Mus musculus) yang terinfeksi Salmonella typhi. Penelitian ini merupakan penelitian eksperimental dengan desain penelitian pre test and post test control group. Hasil penelitian ini ditemukan nilai P < 0,05 (p= 0,000) yang menunjukkan terdapat penurunan rerata kadar kolesterol, glukosa darah, dan asam urat pada mencit yang telah terinfeksi Salmonella typhi. Melalui penelitian ini dapat diketahui pengaruh pemberian madu terhadap kadar kolesterol, glukosa darah, dan asam urat pada mencit yang terinfeksi Salmonella typhi.