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All Journal Jurnal Kedokteran Brawijaya The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Sofia Nuri
Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Islam Malang
Medicine & Pharmacology

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Pengaruh Diet Sambal Tomat Ranti pada Struktur dan Fungsi Hepar Tikus yang Diinduksi Tawas Sulistyowati, Erna; Purnomo, Yudi; Nuri, Sofia; Audra P, Fajar
Jurnal Kedokteran Brawijaya Vol 27, No 3 (2013)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (550.897 KB) | DOI: 10.21776/ub.jkb.2013.027.03.6

Abstract

Masyarakat  Indonesia  mempunyai  kebiasaan  mengkonsumsi  sambal  yang  mengandung  antioksidan.  Paparan  radikal bebas  salah  satunya  tawas  yang  terdapat  pada  air  maupun makanan  bisa  merusak struktur  dan  fungsi  hepar .  Penelitian  ini bertujuan untuk membuktikan pengaruh diet sambal yakni paduan cabe rawit (Capsicum frutescens)  dengan tomat ranti (Lycopersicum  pimpinellifolium  Mill) pada  struktur  hepar  dan  kadar  SGOT  dan  SGPT  tikus  yang  dinduksi  tawas  secara  akut. Penelitian  eksperimental  laboratorium  dilakukan  dengan  post  test  only  with  control  group  design.  Hewan  coba  tikus  dibagi menjadi enam kelompok yaitu kontrol negatif, kontrol positif (induksi tawas 8%), kelompok perlakuan diet tomat ranti 100%,  paduan  tomat  ranti  100,  dengan  cabai  rawit 25%,  50%  dan  100%.  Struktur  hepar  diamati  dengan  menghitung jumlah  nekrosis sel  melalui pulasan Hematoxylin Eosin. Fungsi hepar diamati  melalui pemeriksaan  kadar SGOT dan SGPT. Analisa  data  menggunakan  uji  One  Way  ANOVA,  dilanjutkan  dengan  post  hoc  test  menggunakan  Least  Significant Difference  (LSD).Pemberian  cabai  rawit  dapat  meningkatkan  jumlah  nekrosis  sel  hepar  dan  meningkatkan  kadar  SGOT  dan SGPT  secara  signifikan  bila  dibandingkan  dengan  pemberian tomat  ranti  (tanpa  cabai  rawit). Penambahan  cabai  rawit meningkatkan  kerusakan  struktur  dan  fungsi  hepar  yang  diinduksi  tawas.
Comparison of Quality of Life in Chronic Liver Disease Patients Based on Indonesian Version of SF-36 Questionnaire Mustika, Syifa; Nuri, Sofia; Jauza, Nadia Alfiani; F, Sri Lestari; Nugroho, Rama Tiar; Kalal, Chetan Ramesh
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025255-262

Abstract

Background: Liver cirrhosis is a chronic progressive disease associated with substantial morbidity and mortality. Although clinical management often emphasizes physical outcomes, assessment of health-related quality of life (HRQoL) provides a more comprehensive evaluation of patient well-being. A validated multidimensional instrument for HRQoL assessment is SF-36 (36-Item Short Form Health Survey). Therefore, this study aims to compare HRQoL among patients with chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC) using Indonesian version of SF-36. There are limited data from Indonesia comparing HRQoL across different stages of chronic liver disease, particularly including patients with chronic hepatitis.Methods: A cross-sectional study was conducted at Gastroenterohepatology Clinic of Saiful Anwar General Hospital, Malang, using 273 patients including 156 with chronic hepatitis, 88 with liver cirrhosis, and 29 with HCC. HRQoL was assessed using SF-36 questionnaire, which evaluated eight domains. Data were analyzed through Kruskal–Wallis test followed by Mann–Whitney post hoc analysis.Results: The results showed that HRQoL differed significantly across all SF-36 domains among the three groups (p 0.001), with the lowest scores observed in patients with HCC. Post hoc analysis showed a progressive decline in quality of life with increasing disease severity. However, no significant difference was found between cirrhosis and HCC groups in role limitations due to emotional problems (p 0.05).Conclusion: Advanced stages of chronic liver disease are associated with poorer HRQoL. Emotional role limitations appear less dependent on disease severity, signifying the need for psychological support across all stages.
Co-Authors Erna Sulistyowati F, Sri Lestari Fajar Audra P Jauza, Nadia Alfiani Kalal, Chetan Ramesh Nugroho, Rama Tiar Syifa Mustika Yudi Purnomo