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All Journal Interdental Jurnal Kedokteran Gigi (IJKG) Makara Journal of Science Bulletin of Chemical Reaction Engineering & Catalysis
Nurrahmi Handayani
Analytical Chemistry Division, Department Of Chemistry, Institut Teknologi Bandung, Bandung
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Medicine & Pharmacology Public Health

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The Microwave-assisted Synthesis of Polyethersulfone (PES) as A Matrix in Immobilization of Candida antarctica Lipase B (Cal-B) Khusna Widhyahrini; Nurrahmi Handayani; Deana Wahyuningrum; Santi Nurbaiti; Cynthia Linaya Radiman
Bulletin of Chemical Reaction Engineering & Catalysis 2017: BCREC Volume 12 Issue 3 Year 2017 (December 2017)
Publisher : Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.9767/bcrec.12.3.774.343-350

Abstract

Candida antarctica lipase B (Cal-B) has been widely used in the hydrolysis reaction. However, it has some weaknesses, such as: forming of the heavy emulsion during the process, which is difficult to resolve and has no reusability. Therefore, it needs to be immobilized into a suitable matrix. One of the suitable supporting materials is polyethersulfone (PES) and its synthesis becames the objective of this paper. The PES was synthesized via a polycondensation reaction between hydroquinone and 4,4'-dichlorodiphenylsulfonein N-methylpyrrolidone (NMP) as solvent using Microwave Assisted Organic Synthesis (MAOS) method at170 °C for 66 minutes using an irradiation power of 300 watt. The synthesized PES was characterized by FTIR and 1H-NMR (500 MHz, DMSO-d6). Then the PES membrane was prepared from 20 % of the optimized mixtures of PES, PSf (polysulfone), and PEG (polyethylene glycol) dissolved in 80 % NMP.  The Cal-B was immobilized on the PES membrane by mixing it in a shaker at 30 °C and 100 rpm for 24 h using phosphate buffered saline (PBS). The identification of the immobilized Cal-B was done by using FTIR-ATR spectroscopy and SEM micrographs. The results of Lowry assay showed that the ‘Cal-B immobilized’ blended-membrane has a loading capacity of 91 mg/cm2 in a membrane surface area of 17.34 cm2. In this work, the activity of immobilized Cal-B was twice higher than the native enzyme in p-NP (p-Nitrophenolpalmitate) hydrolyzing. The results indicated that the synthesized PES showed a good performance when used as a matrix in the immobilization of Cal-B. 
Anthrone-based Dummy Molecularly Imprinted Polymer for the Selective Detection of Fluorene and Phenanthrene in Simulated River Water Pinandita, Aria; Handayani, Nurrahmi; Iqbal, Muhammad; Triadhi, Untung; Rusnadi, Rusnadi; Djajanti, Samitha Dewi; Amran, Muhammad Bachri; Zulfikar, Muhammad Ali
Makara Journal of Science Vol. 30, No. 1
Publisher : UI Scholars Hub

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Abstract

A dummy-template molecularly imprinted polymer (DMIP) was synthesized via precipitation polymerization using anthrone as a template analog for the selective analysis of low-molecular-weight polycyclic aromatic hydrocarbons (PAHs), specifically fluorene and phenanthrene. Styrene, benzoyl peroxide, and ethylene glycol dimethacrylate were employed as the functional monomer, radical initiator, and crosslinking agent, respectively. The synthesized polymers were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, and particle size analysis. The imprinting factors were 1.16 and 1.09 for fluorene and phenanthrene, respectively, indicating enhanced affinity of the imprinted sites. High-performance liquid chromatography analysis following DMIP-based solid-phase extraction yielded recoveries of 91.49% ± 3.87% for fluorene and 97.25% ± 2.85% for phenanthrene, demonstrating the DMIP’s potential as an efficient sorbent for selective extraction and quantification of low-molecular-weight PAHs in simulated river water.
Mechanical, Chemical, And Morphological Characterization Of 1% Nanofiber-Reinforced Self-Cure Acrylic For Denture Applications Ira Artilia; Gina Adry Syahira; Zwista Yulia Dewi; Asih Rahaju; Rheni Safira Dewi; Nunung Nuraeni; Nurrahmi Handayani; Atia Nurul Sidiqa
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 22 No. 2 (2026): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v22i2.14342

Abstract

Introduction: Self-curing resin acrylic (SC-AR) is widely used for biomedical appliances, particularly prostheses, due to its rapid manipulation and suitability for single-visit fabrication. However, its relatively low mechanical strength may increase fracture susceptibility. This study evaluated the effect of incorporating 1 wt% polyacrylonitrile polymethyl methacrylate electrospinning nanofibers (e-nanoPAN-PMMA) on the physicochemical, mechanical, and morphological characteristics of SC-AR. Materials and Methods: SC-AR specimens were divided into conventional SC-AR (SC-ARc) and nano-reinforced SC-AR (SC-ARnano) groups. Chemical characteristics were evaluated using X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). Flexural strength (FS) and flexural modulus (FM) were assessed using a three-point bending test, while fracture-surface morphology was examined using scanning electron microscopy (SEM). Data were analyzed using an independent t-test (P≤0.05). Results and Discussion: SC-ARnano exhibited significantly higher FS and FM than SC-ARc (P≤0.05). XRD patterns showed characteristic polymeric resin features in both groups, with no additional crystalline peaks in SC-ARnano. FTIR revealed a nitrile absorption band in SC-ARnano. SEM demonstrated nanofibers embedded within the resin matrix, with no detectable surface porosity. Conclusion: Incorporation of 1 wt% e-nanoPAN-PMMA significantly improved the mechanical properties of SC-AR while maintaining its physicochemical characteristics. SC-ARnano demonstrates potential as a reinforced acrylic resin for biomedical applications.
Co-Authors Asih Rahaju Atia Nurul Sidiqa Cynthia Linaya Radiman Cynthia Linaya Radiman Deana Wahyuningrum Djajanti, Samitha Dewi Gina Adry Syahira Ira Artilia Khusna Widhyahrini Muhammad Ali Zulfikar Muhammad Bachri Amran Muhammad Iqbal Nunung Nuraeni Pinandita, Aria Rheni Safira Dewi Rusnadi Rusnadi Santi Nurbaiti Triadhi, Untung Zwista Yulia Dewi