Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer Chemoprevention Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement)
Ika Nurzijah
Cancer Chemoprevention Research Center Faculty of Pharmacy Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Medicine & Pharmacology

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
Ficus septica burm. F. Leaves Ethanolic Extract Induces Apoptosis in 7,12-dimethylbenz[a]nthracene-induced Rat Liver Cancer Quatitavely Septhea, Dita Brenna; Anindyajati, .; Darma, Andita Pra; Nurzijah, Ika; Nugroho, Agung Endro
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

The chemopreventive effect of  Ficus septica Burm. f. leaves ethanolic extract (FLEE) was studied in 7,12-dimethylbenz[a]nthracene (DMBA)-induced rat liver cancer. Rats were divided into 5 group, 5 rats (5 wk of age Sprague Dawley rat) in each group. Group 1 was control diet group, administered with 0,5% CMC-Na as vehicle. FLEE was administered 750 mg/kgBW and 1500 mg/kgBW starting 4 wk until 5 wk after DMBA administration at the first until fifth wk to group 2 and group 3. Group 4 was control extract group, administered  with 750 mg/kgBW and  group  5  was  DMBA  group.  DMBA  is  a  carcinogen  to  induce  liver  cancer  was  also administered in DMBA control group and all animals were necropsied at 6 wk after DMBA administration. Activity of inducing apoptosis was detected using Double Staining method in 750 mg/kgBW FLEE group compared to control group but no in 1500 mg/kgBW FLEE group resulted in 100% dead. Apoptotic cells would have orange flourescence but normal cells would have green flourescence detected by flourescence microscope. To investigate the protein that involved in apoptotic mechanism, we studied p53 expression using Imunohistochemistry (IHC). There was no difference expression of p53 in both tested and control groups. Based on the results, FLEE has a potency as chemoprentive agent because its activity on inducing apoptosis in liver  cancer  with  p53-independent  pathway.  The  mechanism  of  apoptosis  induction  of  this extract needs to be explored by observing the expression of related proteins. Key words: apoptosis, Ficus septica, liver cancer, p53 independent pathway
Ficus septica Burm.f. Leaves Ethanolic Extract Triggered Apoptosis on 7,12-Dimethylbenz[a]anthracene-Induced Rat Mammary Carcinogenesis Qualitatively Anindyajati, .; Darma, Andita Pra; Nurzijah, Ika; Septhea, Dita Brenna; Nugroho, Agung Endro
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Ficus septica Burm.f.ethanolic extract (FEE) shows cytotoxic effects on several cancer cell lines. Our research aimed to investigate the effect of FEE on apoptosis induction and p53 expression against carcinogenesis of 7,12-Dimenthylbenz[a]anthracene (DMBA)-induced rat mammary. The research was conducted by comparing both apoptosis induction and p53 expression in DMBA-induced rats that were treated with FEE against control groups. Cells that undergo apoptosis were visualized by Double Staining method with acridine orange and ethidium bromide, while p53 expression was detected by IHC staining. Double staining result showed increased occurrence of apoptotic cells compared to the control groups. IHC staining pf P53 did not show significant difference between treatment and control groups. However, FEE was able to repair morphology of cells undergoing carciogenesis. Thus, we conclude that FEE has an anti carciogenic activity on DMBA-induced rat mammary through apoptosis induction without affecting p53 expression. Therefore, the ethanolic extract of Ficus septica leaves is a potential chemo-preventive agent on breast cancer. Further study on its molecular mechanism needs to be exploredKeywords: Ficus septica, breast cancer, 7,12-Dimethylbenz[a]anthracene, carciogenesis, apoptosis, p53
Secang (Caesalpinia sappan L.) Heartwood Ethanolic Extract Shows Activity as Doxorubicin Co-chemotherapeutic Agent by Apoptosis Induction on T47D Breast Cancer Cells Nurzijah, Ika; Putri, Dyaningtyas Dewi Pamungkas; Rivanti, Erlina; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 3, No 2 (2012)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

Abstract

Doxorubicin, primary chemoteurapeutic agent used for breast cancer treatment, is known to have various side effects included multi drug resistance 9MDR) phenomenon. Therefore, exploration of co-chemotherapeutic agent is important to be conducted in order to prevent MDR. Secang (Caesalpinia sappan L.) which contains active compounds brazilin and brazilein, is proven to have activity as anticancer. The aim of this study is to determine the potency of Caesalpinia sappan L.ethanolic extract (CEE) as co-chemotherapeutic agent of doxorubicin and its mechanism through apoptosis induction on T47D breast cancer cells. Caesalpinia sappan L. heartwood powder was macerated with ethanol 70%. The cytotoxic effect of CEE alone and its combination with doxorubicin was analyzed using MTT assay. Apoptosis assay was done by flowcytometry-annexin V method. CEE showed cytotoxic activity on T47D cells with IC50 value of 35 μg/ml, while combinatorial test showed that all of combination doses of CEE and doxorubicin gave synergistic effect. Flowcytometry-annexin V assay proved that treatment of CEE induced apoptosis of doxorubicin. Based on these results, we conclude that Caesalpinia sappan L. heartwood ethanolic extract is potential to be developed as co-chemotherapeutic agent of doxorubicin.Keywords : Caesalpinia sappan L., doxorubicib, apoptosis, T47D cells. 
Promoting Antimicrobial Stewardship in Small Ruminants by Assessing Farmer’s Behavior and Establishing Footbath Strategy at a Community Farm in Purbalingga, Central Java Nurzijah, Ika; Prasuma, Galar Sigit; Darmansah, Muhammad Aris; Berliana, Widya Pratiwi; Akbar, Mohammad Rekhan
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 11, No 3 (2025): September
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.106218

Abstract

Infectious diseases such as lameness remain a persistent health problem for small ruminants in community farming systems. Although antimicrobials are frequently used as a treatment strategy, this practice contributes to increased medication use and raises concerns over antimicrobial resistance. This study assessed behavioral practices surrounding antimicrobial use among farmers at Ngudi Dadi, a community farm in Central Java, Indonesia, and implemented a multifaceted intervention combining farmer training and the construction of a biosecurity-focused footbath.Behavioral data were collected through structured survey with 21 farmers, covering five domains: antimicrobial administration, disposal of veterinary medicines, frequency of antimicrobial use, medication storage, and treatment of sick animals. Behavioral scores varied across categories, with consistently higher scores for treatment practices, but notable gaps in antimicrobial administration and disposal behaviors. Importantly, no significant correlation was observed between years of farming experience and behavioral practice scores (Spearman’s ρ = 0.0488, p = 0.8335), suggesting that practice gaps are widespread regardless of farming experience.Post-survey, a training session was conducted, followed by the construction of a footbath using lemongrass essential oil as a natural disinfectant. The footbath is now routinely used for incoming livestock at Ngudi Dadi Farm, serving as a biosecurity measure that supports reduced reliance on antimicrobials.This study represents the first initiative in Indonesia to integrate behavioral assessment, farmer education, and footbath implementation into a comprehensive antimicrobial stewardship strategy. Expansion of this model to other community farming settings, along with the development of standardized operating procedures, may enhance its scalability and long-term impact.
Co-Authors . Anindyajati Agung Endro Nugroho Akbar, Mohammad Rekhan Andita Pra Darma Berliana, Widya Pratiwi Darmansah, Muhammad Aris Dita Brenna Septhea Dyaningtyas Dewi Putri Pamungkas Edy Meiyanto Erlina Rivanti Prasuma, Galar Sigit