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All Journal Jambura Journal of Health Sciences and Research Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Pendidikan dan Konseling Archives of The Medicine and Case Reports Bioscientia Medicina : Journal of Biomedicine and Translational Research Asian Journal of Social and Humanities
Meldawati
Department Of Medicine, Faculty Of Medicine, Universitas Prima Indonesia, Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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The Effect of Moringa Oleifera Extract on Sperm Quality and Quantity of Diabetes Wistar Rat Meldawati; Novita Dwi Febrianty; Herisa Putri Anggraini; Boyke Marthin Simbolon
Archives of The Medicine and Case Reports Vol. 2 No. 1 (2021): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v2i1.15

Abstract

Diabetes mellitus is a condition in which blood glucose levels increase in a person's body which can result in chronic disorder. The effect of diabetes on a male reproductive system can affect sperm quality and disrupt the spermatogenesis process. Moringa oleifera leaves are rich in antioxidants such as flavonoids, vitamin A, vitamin E, and vitamin C, and contain selenium which helps lower bloodssugar levels. This study was conductedtto determine the effect of administering Moringa oleifera leaf extract on the quality andiquantity ofssperms in Wistar rats with diabetes mellitus. This research is an experimental studyiusing pre-andipost-randomized,controlled group design. This study examinediblood sugarllevels, density, motility, andiviability ofssperm cells. This experimental test was dividediinto 4 groups: one as a control group andtthree groups as treatment groups induced with alloxan and given ethanol extract of Moringa leaves with doses of 250, 500, and,750mg/kgBB. The results showed that the ethanol extract of Moringa leaves showedssignificant improvements in various doses (P-value ≤ 0.05).
TEST THE EFFECTIVENESS OF SENGGANI LEAF EKSTRACT (Melastoma candidum D.Don) AGAINST Propionibacterium acnes suryana ayu lestari; meldawati meldawati
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.13830

Abstract

Senggani (Melastoma candidum D.Don) merupakan tanaman liar yang mengandung beberapa senyawa aktif yang dapat dimanfaatkan sebagai antibakteri. Kebaruan dalam penelitian ini adalah melakukan uji efektivitas ekstrak daun senggani (melastoma candidum d.don) terhadap propionibacterium acnes. Tujuan penelitian ini untuk mengetahui daya hambat ekstrak daun senggani terhadap bakteri Propionibacterium acnes. Ekstrasi dilakukan dengan cara maserasi dengan menggunakan pelarut etanol 96%. Jenis penelitian ini merupakan penelitian eksperimental dengan metode difusi cakram. Perlakuan diulang sebanyak 4 kali dengan konsentrasi 20%, 40%, 60%, 80%, dan 100%, sebagai kontrol positip digunakan clindamycin dan DMSO (Dimethyl sulfoxide) sebagai kontrol negatif. Hasil skrining fitokimia menunjukkan bahwa daun senggani mengandung senyawa, saponin, flavonoid, fenol, tannin, steroid, dan terpenoid. Hasil yang diketahui bahwa ekstrak daun senggani memiliki kemampuan menghambat pertumbuhan bakteri Propionibacterium acnes terlihat dengan adanya zona hambat yang terbentuk. Konsentrasi yang paling efektif menghambat pertumbuhan Propionibacterium acnes yaitu konsentrasi 100% sebesar 16,37 mm. Daun senggani memiliki daya hambat dalam menghambat pertumbuhan bakteri Propionibacterium acnes. Konsentrasi yang paling efektif adalah konsentrasi 100% sebesar 16,37 mm.Kata kunci: Melastoma candidum D.Don; Propionibacterium acnes; antibakteri; ekstrak ABSTRACTSenggani (Melastoma candidum D.Don) is a wild plant that contains several active compounds that can be used as antibacterial. The novelty in this research is to test the effectiveness of senggani leaf extract (Melastoma candidum d.don) against Propionibacterium acnes. The purpose of this study was to determine the inhibition of senggani leaf extract against Propionibacterium acnes bacteria. Extraction is done by maceration using 96% ethanol solvent. This type of research is an experimental study with disk diffusion method. The treatment is repeated 4 times with concentration 20%, 40%, 60%, 80%, and 100%, as a positive control used clindamycin and DMSO (Dimethyl sulfoxide) as a negative control. Phytochemical screening results showed that senggani leaves contain compounds, saponins, flavonoids, phenols, tannins, steroids, and terpenoids. The results are known that senggani leaf extract has the ability to inhibit the growth of Propionibacterium acnes bacteria seen in the presence of inhibitory zones formed. The most effective concentration to inhibit the growth of Propionibacterium acnes is 100% concentration of 16.37 mm. Senggani leaves have inhibitory power in inhibiting the growth of Propionibacterium acnes bacteria. The most effective concentration is a 100% concentration of 16.37 mm.
EFFECTIVITY OF SENGGANI LEAF EXTRACT (Melastoma candidum D.Don) ON BACTERIA Staphylococcus Epidermidis Safira Suwita; Meldawati Meldawati
Jambura Journal of Health Sciences and Research Vol 4, No 2 (2022): JULI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i2.13832

Abstract

Abstrak Tanaman Senggani (Melastom Candidum D.Don) merupakan salah satu tanaman liar yang terdapat diseluruh Indonesia dan memiliki banyak khasiat. Kebaruan dalam penelitian ini karena meneliti  efektivitas ekstrak daun senggani (melastoma candidum d.don) terhadap bakteri staphylococcus epidermidis. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak daun senggani (Melastoma Candidum D.Don) terhadap bakteri Staphylococcus Epidermidis. Dalam pengujian antibakteri menggunakan konsentrasi ekstrak 20%, 40%, 60%, 80%, 100%. Sebagai kontrol positif menggunakan Clindamycin dan sebagai kontrol negatif menggunakan DMSO. Metode penelitian menggunakan metode difusi cakram. Hasil uji skrining fitokimia membuktikan bahwa daun senggani memiliki kandungan senyawa flavonoid, fenol, saponin, tannin, steroid dan terpenoid, hasil penelitian menunjukkan zona hambat terbesar pada konsentrasi 100% yaitu 18,37 mm, dan untuk zona hambat terkecil didapatkan pada konsentrasi 20% yaitu 14,76 mm. Kesimpulan ekstrak daun senggani memiliki aktivitas antibakteri terhadap staphylococcus epidermidis dengan kategori kuat. Kata kunci: Antibakteri; Eksrak; Melastoma candidum D.Don; Staphylococcus epidermidis.  Abstract Senggani Plant (Melastom Candidum D.Don) is one of the wild plants found throughout Indonesia and has many properties. The novelty in this research is the effectiveness of senggani leaf extract (Melastoma candidum d.don) against Staphylococcus epidermidis bacteria. This study aims to determine the effectiveness of senggani leaf extract (Melastoma Candidum D.Don) against Staphylococcus Epidermidis bacteria. In antibacterial testing using extract concentration 20%, 40%, 60%, 80%, 100%. As a positive control using Clindamycin and as a negative control using DMSO. The research method uses the disc diffusion method. Phytochemical screening test results prove that senggani leaves contain flavonoid compounds, phenols, saponins, tannins, steroids and terpenoids, the results showed the largest inhibition zone at 100% concentration of 18.37 mm, and for the smallest inhibition zone obtained at a concentration of 20% is 14.76 mm. Conclusion Senggani leaf extract has antibacterial activity against staphylococcus epidermidis with a strong Category. Keywords: Antibacterial; Extract; Melastoma candidum D.Don; Staphylococcus epidermidis.
Uji Aktivitas Anti bakteri Ekstrak Lidah Buaya (Aloe vera) terhadap Bakteri Pseudomonas aeruginosa dan Streptococcus pyogenes dalila fakhira damanik; Monica -; Yuliani Mardiati Lubis; Meldawati -
Majalah Kedokteran Andalas Vol 44, No 6 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i6.p357-364.2021

Abstract

Lidah buaya merupakan family Liliaceae, yang diketahui sebagai tanaman alami untuk pengobatan serta mempunyai banyak manfaat, diantarannya anti inflamasi, anti bakteri, antikanker, antioksidan, antiulcer, antidiabetes. Tujuan: penelitian ini mencari tahu aktivitas antibakteri ekstrak lidah buaya dengan bakteri Pseudomonas aeruginosa dan Streptococcus pyogenes. Metode: metode difusi dengan kertas cakram, dengan rancangan penelitian, postest only control group design. Pada lidah buaya menggunkan ekstrak dengan konsentrasi 25%, 50%, 75% dan 100%, untuk control positif menggunakan ciprofloxacin dan control negative menggunkan aquadest. Hasil: penelitian menunjukan ekstrak daging lidah buaya tidak memiliki daya hambat pada konsentrasi 25%,50%,75%,dan 100% yang sudah dilakukan 4 kali ulangan terhadap bakteri Pseudomonas aeruginosa dan Streptococcus pyogenes. Simpulan: penelitian ini ekstrak daging lidah buaya yang tidak memiliki daya hambat terhadap bakteri Pseudomonas aeruginosa dan Streptococcus pyogenes sehingga tidak dapat ditentukan efektifitasnya.
Antibacterial Potential of Methanol Extract of Red Guava Leaves (Psidium guajava L.) Against Salmonella typhi Gabriella Marchelita Ginting; Ira Gracela; Meldawati; Adek Amansyah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 15 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i15.685

Abstract

Background: Typhoid fever is a fever caused by an infection of the gastrointestinal tract, where the infection is caused by the bacterium Salmonella typhi. This infection is generally found in environmental conditions with dense populations and poor hygiene levels. Various plants have been used from generation to generation to treat typhoid fever, one of which is red guava leaves. This study aims to further explore the potential of methanol extract of red guava leaves (Psidium guajava L.) on the activity of Salmonella thyphi in vitro. Methods: This study is an in vitro experimental study using Salmonella thyphi culture. The phytochemical screening test was carried out on the methanol extract of red guava leaves. Furthermore, an assessment of the diameter of the inhibition zone between groups was carried out. Univariate and bivariate analyzes were performed to compare between groups. Results: There was an increase in the diameter of the inhibition zone along with an increase in the dose of methanol extract from red guava leaves. A dose of 100 mg/mL of red guava leaf extract showed a maximum inhibition diameter of 11.85 cm. Conclusion: Methanol extract of red guava leaves (Psidium guajava L.) has the antibacterial activity of Salmonella thyphi along with increasing concentrations.
Antibacterial Potential of Methanol Extract of Red Guava Leaves (Psidium guajava L.) Against Salmonella typhi Gabriella Marchelita Ginting; Ira Gracela; Meldawati; Adek Amansyah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 15 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i15.685

Abstract

Background: Typhoid fever is a fever caused by an infection of the gastrointestinal tract, where the infection is caused by the bacterium Salmonella typhi. This infection is generally found in environmental conditions with dense populations and poor hygiene levels. Various plants have been used from generation to generation to treat typhoid fever, one of which is red guava leaves. This study aims to further explore the potential of methanol extract of red guava leaves (Psidium guajava L.) on the activity of Salmonella thyphi in vitro. Methods: This study is an in vitro experimental study using Salmonella thyphi culture. The phytochemical screening test was carried out on the methanol extract of red guava leaves. Furthermore, an assessment of the diameter of the inhibition zone between groups was carried out. Univariate and bivariate analyzes were performed to compare between groups. Results: There was an increase in the diameter of the inhibition zone along with an increase in the dose of methanol extract from red guava leaves. A dose of 100 mg/mL of red guava leaf extract showed a maximum inhibition diameter of 11.85 cm. Conclusion: Methanol extract of red guava leaves (Psidium guajava L.) has the antibacterial activity of Salmonella thyphi along with increasing concentrations.
Hubungan Kadar Gula Darah dan Indeks Massa Tubuh terhadap Kejadian Preeklamsia-Eklamsia Daniel Muliadi Vito; Adek Amansyah; Meldawati Meldawati
Jurnal Pendidikan dan Konseling (JPDK) Vol. 4 No. 5 (2022): Jurnal Pendidikan dan Konseling
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jpdk.v4i5.7745

Abstract

Preeklamsia merupakan salah satu kondisi hipertensi pada kehamilan yang dapat menyebabkan masalah pertumbuhan janin dan bahkan kematian pada janin dan ibu. Salah satu faktor pemicu dari kondisi ini adalah peningkatan kadar gula darah (KGD) dan indeks massa tubuh (IMT) > 30 1–3. Penelitian ini bertujuan untuk menemukan hubungan antara variabel kadar gula darah sewaktu dan indeks massa tubuh pada kejadian preeklamsia-eklamsia pada ibu hamil. Desain cross-sectional digunakan dalam penelitian ini. Pengumpulan data dilakukan pada RS Royal Prima Medan dan RS K.H. Daud Arif Kuala Tungkal dalam jangka waktu Juni – Agustus 2022 dengan jenis data sekunder berupa rekam medis. Sebanyak 54 data sekunder yang memenuhi kriteria inklusi berupa ibu hamil > 20 minggu disertai dengan data antropometri, kadar gula darah sewaktu, tekanan darah serta status proteinuria dan riwayat obstetrik, diambil dan digunakan pada penelitian ini. Sampel penelitian cenderung memiliki IMT < 30 dengan jumlah 45 orang (83,3%) dan 9 orang (16,7%) diantaranya memiliki IMT > 30 atau obesitas. Sedangkan KGD pada sampel terbagi rata pada kedua kelompok, 27 orang (50%) pada masing masing kelompok KGD ? Median (88,5 mg/dL) dan > Median (88,5 mg/dL). Tidak tampak hubungan signifikan antara IMT dan kejadian preeklamsia-eklamsia dengan nilai P = 0,142, namun terdapat beda rerata yang signifikan (nilai P < 0,05) antara kelompok kontrol (median IMT 23,44) dan kasus (median IMT 26,56). Hubungan yang signifikan antara kadar gula darah sewaktu dan kejadian preeklamsia-eklamsia dapat disimpulkan (P < 0,05), serta beda rerata yang signifikan antara kelompok kontrol (median KGD 82 mg/dL) dan kelompok kasus (median KGD 95 mg/dL).
Hubungan Antara Nilai Neutrophil Lymphocyte Ratio (NLR) dan Indeks Massa Tubuh (IMT) terhadap Kejadian Preeklampsia pada Wanita Hamil Andreas Natanael Siagian; Adek Amansyah; Meldawati Meldawati
Jurnal Pendidikan dan Konseling (JPDK) Vol. 4 No. 6 (2022): Jurnal Pendidikan dan Konseling
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jpdk.v4i6.8417

Abstract

Preeklampsia adalah kumpulan gejala yang ditandai dengan hipertensi dan protein dalam urin, umumnya terjadi pada kehamilan diatas 20 minggu. Nilai neutrophil lymphocyte ratio (NLR) yang meningkat menunjukkan adanya inflamasi sistemik dan disfungsi endotel yang terjadi pada penderita preeklampsia. Tujuan penelitian ini untuk menilai hubungan antara nilai neutrophil lymphocyte ratio (NLR) dan indeks massa tubuh (IMT) terhadap kejadian preeklampsia pada wanita hamil. Penelitian ini menggunakan pendekatan cross sectional. Pengambilan data sampel dilaksanakan di RSU. Royal Prima Medan dan RSU. Royal Prima Jambi dalam jangka waktu Januari - Agustus 2022 dengan jenis data sekunder berupa rekam medis. Jumlah sampel penelitian ini 50 orang. Berdasarkan IMT sampel penelitian cenderung memiliki BMI < 30 dengan jumlah 41 orang (82,0%) dan 9 orang (18.0%) memiliki BMI > 30 atau obesitas. Berdasarkan NLR sampel terbagi pada dua kelompok, kelompok NLR ? Median (3,46) 24 orang (48,0%), pada kelompok NLR > Median (3,46) 26 orang (52,0%). Dapat dilihat tidak adanya hubungan yang signifikan antara IMT dan preeklampsia dengan nilai P = 0,066, namun terdapat beda rerata yang signifikan (P <0,05) dengan kelompok kontrol (median 23,43) dan kasus (median 26,67). Terdapat hubungan yang signifikan antara NLR dengan kejadian preeklampsia (P < 0,05), serta beda rerata yang signifikan dengan kelompok kontrol (median 2,99) dan kasus (media 4,27).
The Relationship of Various Physical Activities To Menopausal Symptoms Naurah Al’Ariqoh; Adek Amansyah; Meldawati Meldawati
Asian Journal of Social and Humanities Vol. 2 No. 03 (2023): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i03.195

Abstract

The purpose of this study was to identify the relationship of various physical activities to menopausal symptoms in women aged 50-60 years in the work area of the Ujunggading Health Center. Research Method: This study uses a correlation research design with a cross sectional approach model with a sample of 75 respondents with a non-probability sampling method, namely using purposive sampling, data collection using GPAQ and MRS questionnaires, data analysis using correlation tests. Results: The results of the study of 75 respondents found the frequency distribution of respondents' characteristics with the most jobs as housewives, namely 23 people (30.7%), the most junior high school education was 20 people (26.7%), and the most menopause duration of 5-7 years, which was 36 people (48.0%). Showing that most respondents had moderate category physical activity 54 (72%) and most respondents experienced moderate category menopausal symptoms 37 (49.3%) There was a relationship between physical activity and menopausal symptoms with p value = 0.000 (p < 0.05). Conclusion: There is a relationship between physical activity and menopausal symptoms where the higher the physical activity carried out, the less menopausal symptoms are felt, menopausal symptoms can be reduced by routinely doing activities and exercising for 15 to 60 minutes every day
The Relationship of Various Physical Activities To Menopausal Symptoms Naurah Al’Ariqoh; Adek Amansyah; Meldawati Meldawati
Asian Journal of Social and Humanities Vol. 2 No. 03 (2023): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i03.195

Abstract

The purpose of this study was to identify the relationship of various physical activities to menopausal symptoms in women aged 50-60 years in the work area of the Ujunggading Health Center. Research Method: This study uses a correlation research design with a cross sectional approach model with a sample of 75 respondents with a non-probability sampling method, namely using purposive sampling, data collection using GPAQ and MRS questionnaires, data analysis using correlation tests. Results: The results of the study of 75 respondents found the frequency distribution of respondents' characteristics with the most jobs as housewives, namely 23 people (30.7%), the most junior high school education was 20 people (26.7%), and the most menopause duration of 5-7 years, which was 36 people (48.0%). Showing that most respondents had moderate category physical activity 54 (72%) and most respondents experienced moderate category menopausal symptoms 37 (49.3%) There was a relationship between physical activity and menopausal symptoms with p value = 0.000 (p < 0.05). Conclusion: There is a relationship between physical activity and menopausal symptoms where the higher the physical activity carried out, the less menopausal symptoms are felt, menopausal symptoms can be reduced by routinely doing activities and exercising for 15 to 60 minutes every day
Co-Authors Adek Amansyah Andreas Natanael Siagian dalila fakhira damanik Daniel Muliadi Vito Gabriella Marchelita Ginting Herisa Putri Anggraini Ira Gracela Monica - Naurah Al’Ariqoh Novita Dwi Febrianty Safira Suwita Simbolon, Boyke Marthin suryana ayu lestari Yuliani Mardiati Lubis