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All Journal Medica Hospitalia Bioscientia Medicina : Journal of Biomedicine and Translational Research
Najatullah Najatullah
Bagian Bedah Plastik Fakultas Kedokteran Universitas Diponegoro, Semarang
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Effect of Ethanolic Extract of Moringa oleifera Leaves on the Macrophage Count and VEGF Expression on Wistar Rats with Burn Wound Agnes Stella Valentina; Najatullah; Trilaksana Nugroho; Neni Susilaningsih
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.535

Abstract

Background: One modality type of burn wound therapy is topical silver sulfadiazine. Recently, research about topical herb medicine has grown. Moringa oleifera (MO) is a kind of herb plant that has an anti-inflammation effect and has an influence on angiogenesis, so it tends to faster burn wound healing. This study aimed to prove the effect of ethanolic extract of Moringa oleifera leaves on the macrophage count and VEGF expression in Wistar rats with burn wounds. Methods: The research design that was used is "Randomized post-test with a control group." The study population used 24 male Wistar rats that were induced burn wounds and randomly divided into 4 groups which were given medicine topically once daily for 7 days. Treatment groups included: I (MO leaves extract 10%), II (SSD + MO leaves extract 10%), III (SSD), dan IV (pure vehiculum). Exudation was assessed macroscopically, while PMN and macrophage amount were assessed microscopically with Hematoxylin-Eosin. Data were analyzed and processed using hypothesis test One Way ANOVA – Post Hoc Bonferroni, Kruskal Wallis – Mann Whitney, and correlation test Spearman and Pearson with SPSS 25.0 program. Results: Significant difference obtained in macrophage amount between II group and IV group (p 0,000). There was no significant difference in VEGF expression. There was also no correlation between macrophage amount and VEGF expression. Conclusion: Ethanolic extract of Moringa oleifera leaves extract proved to be effective in decreasing macrophage cell count on Wistar rats with burn wounds.
The Effect of Ethanolic Extract from Moringa oleifera Leaves in Collagen Density and Numbers of New Capillary Vessel Count on Wistar Rats Burn Wound Supandi Andy; Najatullah; Nugroho Trilaksana; Neni Susilaningsih
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 6 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i6.536

Abstract

Background: Burns are a major cause of morbidity, including prolonged length of stay and disability, which requires no small amount of treatment costs. Currently, there are many studies to accelerate the healing of wounds, one of which is with Moringa oleifera (MO). This study aimed to prove the effect of ethanolic extract from MO leaves on collagen density and new capillary vessel count on Wistar rats' burn wounds. Methods: This research is randomized post-test only with a control group design. Twenty-four male Wistar rats induced burn wounds and were randomly divided into 4 groups which were given topical medicine once daily for 10 days; P1 (MO leaves extract 10%), P2 (Silver Sulfadiazine + MO leaves extract 10%), P3 (SSD), and P4 (negative control). Collagen density was assessed using the Kruskal-Wallis test and continued with Mann-Whitney Test. New capillary vessel count was assessed using Hematoxylin-Eosin staining and One Way ANOVA. The correlation test between two variables was tested using the Spearman test. Results: Collagen Density shows significant difference in group P1 compared to P4 (p=0,016), group P2 compared to P3 (p=0,047), group P2 compared to P4 (p=0,009). A significant increase in new capillary blood vessel counts was seen in group P1 compared to P3 and P4 (p=0.001; 0,000) and group P2 compared to P3 and P4 (p=0,000;0,000). A positive correlation was found between the new capillary blood vessel count and epithelization percentage (p=0,001), with a strong correlation (rho=0,682). Conclusion: Ethanolic extract from Moringa oleifera leaves proved to be effective in increasing collagen density and new capillary vessel count.
The Effectiveness of Moringa oleifera Burn Healing: In Vivo Study Duta Indriawan; Najatullah; Trilaksana Nugroho; Neni Susilaningsih
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.602

Abstract

Background: Burns is a type of wound that requires more intensive treatment considering the damage from these wounds is quite massive and very often causes infection. Topical antimicrobials used today have few side effects and are only partially effective in wound healing. The aim of the study was to explore the potential of Moringa oleifera on burn wound healing in vivo. Methods: This study is an experimental study using 24 rats. Rats were grouped into 3 treatment groups and 1 control group. Furthermore, the number of fibroblasts and PMN cells was assessed in the wound tissue. Data analysis was done by univariate and bivariate. Results: The combination of sulfur sulfadiazine and Moringa oleifera was able to significantly increase the number of fibroblasts and reduce PMN cells in burn tissue. Conclusion: Moringa oleifera extract has the potential to accelerate burn healing by inhibiting inflammation and fibroblast activation.
Factors Affecting the Outcome of Breast Reconstruction Surgery in Modified Radical Mastectomy Procedure Wahyu Hendra Prabowo; Najatullah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 5 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i5.816

Abstract

Background: Breast cancer is the leading cause of death in women caused by cancer. The primary treatment for breast cancer is surgery, where several recommended surgical methods are breast-conserving surgery or mastectomy. Postoperative mastectomy reconstruction has provided an opportunity to overcome the emotional and aesthetic burden of malignancy. Methods: This research is a descriptive observational study with a retrospective approach. The sample was 45 breast cancer patients who had undergone a modified radical mastectomy operation at Dr. Kariadi General Hospital for January 2019 - April 2023. The data were processed using SPSS for Windows software, and a descriptive analysis was carried out. Results: Most of the patients who underwent post-MRM breast reconstruction were in the age group >40 years (71.1%), had stage 2 mammary carcinoma (44.4%) and stage 3 (40%), featured invasive ductal carcinoma (84 .4%), breast on the right side (64.4%). Some suffer from hypertension (13.3%) or diabetes mellitus (22.2%). The most used type of reconstruction was STSG (82.2%). A small proportion of patients experienced dehiscence (17.8%). In the Karnofsky score assessment, the highest score was 70 (64.4%), followed by 60 (17.8%), 80 (11.1%), 50 (4.4%), and 40 (2.2%). Conclusion: The patients undergoing MRM are dominated by the age group > 40 years, not suffering from hypertension or diabetes mellitus, stage 2, histopathology of invasive ductal carcinoma, right-sided breast. STSG dominates the choice of reconstruction with postoperative complications in the form of dehiscence in a small proportion of patients. The Karnofsky score is dominated by a score of 70.
The Effectiveness of Macrophage Hydrolyzed VCO Cream in Healing Second Degree Burns in Wistar Rats Fahmi Syarif; Najatullah Najatullah
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.1072

Abstract

Background: Burns are a global public health issue, with many studies on topical medications that are effective in second-degree burns. Hydrolyzed VCO (hVCO) contains lauric acid, polyferol and alpha tocopherol which are beneficial in wound healing. This study was conducted to determine the effectiveness of hVCO cream macrophage formation for second degree burn wound healing in Wistar rats. Methods: A parallel group study was conducted on thirty wistar rats randomly divided into six groups induced second degree burns. Basic cream was applied to two control groups on the 6th and 12th day, 70% hVCO was applied to two groups on the 6th and 12th day, and 100% hVCO was applied to two groups on the 6th and 12th day. Histopathological examination of macrophage formation was conducted in each treatment. Result: The groups with hydrolyzed VCO cream on day 12 (p=0,089) had higher macrophage formation than the same hVCO group on day 6 (p=0,354). The macrophage count of hVCO in each group showed an increase. Conclusion: 100% hVCO is effective in accelerating second degree burn wound healing in terms of macrophage count.
Co-Authors Agnes Stella Valentina Duta Indriawan Fahmi Syarif Neni Susilaningsih Neni Susilaningsih Supandi Andy Trilaksana Nugroho Trilaksana Nugroho Wahyu Hendra Prabowo