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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Cardiology Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia MEDICINUS
Sony Hilal Wicaksono
Department Of Cardiology & Vascular Medicine, Faculty Of Medicine, Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Interpretasi Hasil Pemeriksaan MRI Kardiak pada Penyakit Jantung Koroner Sony Hilal Wicaksono; Fachmi Ahmad Muslim; Vienna Rossimarina
Jurnal Kardiologi Indonesia Vol. 34, No. 1 Januari - Maret 2013
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v34i1.301

Abstract

Seorang pasien dapat didiagnosis penyakit jantung koroner (PJK) melalui empat cara: kematian jantung mendadak, sindrom koroner akut, angina pektoris stabil paska revaskularisasi, dan hasil diagnostik noninvasif (Computed Tomography scan/CT scan koroner, Single Photon Emission Computed Tomography Myocardial Perfusion Imaging/SPECT MPI nuklir atau Magnetic Resonance Imaging/MRI)1. Pemeriksaan noninvasif memegang peranan penting, yaitu sebagai satu-satunya cara mendiagnosis PJK asimtomatik. Oleh sebab itu, pemahaman mengenai interpretasi hasil pemeriksaan noninvasif seperti CT scan koroner, SPECT MPI nuklir atau MRI kardiak dimasukkan dalam kompetensi dasar program pendidikan spesialis jantung dan pembuluh darah menurut Kolegium PERKI.
Nilai Prediktif Mri Kardiak Pasca Stemi Peran Late Enhancement Irnizarifka I; Sony Hilal Wicaksono; Ario Soeryo Kuncoro; Manoefris Kasim
Jurnal Kardiologi Indonesia Vol. 34, No. 3 Juli - September 2013
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v34i3.342

Abstract

Forum Pencitraan Kardiovaskular edisi sebelumnya membahas tentang peran Magnetic Resonancec Imaging (MRI) kardiak pada kasus Penyakit Jantung Koroner dalam kondisi akut maupun kronik. Dalam forum kali ini, kami sajikan contoh kasus penggunaan MRI kardiak pada pasien pasca Infark Miokard Akut Elevasi ST (IMAEST) yang dilakukan pemeriksaan MRI kardiak saat perawatan sebagai stratifikasi risiko pasien pasca IMAEST. Penyakit kardiovaskular masih menjadi penyebab morbiditas dan mortalitas tertinggi di dunia, dengan penyakit arteri koroner (PAK) sebagai manifestasi utamanya.1 Dengan semakin berkembangnya manajemen serangan jantung akut, setidaknya 70% pasien yang dirawat di rumah sakit dengan infark miokard akut (IMA) berhasil melewati fase akutnya. Namun, konsekuensi jangka panjang pasca serangan akut tetap dapat terjadi meskipun intervensi fase akut telah dilakukan. Dengan demikian, ketepatan waktu dalam mendiagnosis IMAEST menjadi sangat penting.
MRI Kardiak untuk Gagal Jantung akibat Kardiomiopati Sony Hilal Wicaksono; Donny Setyawan Syamsul; Citra Primasari; Aprivita Gayatri; Asmoko Resta Permana
Jurnal Kardiologi Indonesia Vol. 34, No. 4 Oktober - Desember 2013
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v34i4.387

Abstract

Kardiomiopati (KM) merupakan penyakit miokardium dengan karakteristik gangguan yang nyata pada morfologi, elektrofisiologi dan fungsi jantung.1 Definisilain menyebutkan bahwa KM adalah kelainan miokardium dengan abnormalitas pada struktur dan fungsi otot jantung, tanpa adanya penyakit jantung koroner, hipertensi, penyakit jantung katup ataupun kongenital yang melatarbelakanginya.Kardiomiopati dapat diklasifikasikan dalam dua kelompok besar yaitu KM primer dan KM sekunder. KM primer merupakankardiomiopati yang etiologinyatidak diketahui sedangkan kardiomiopati sekunder merupakan kardiomiopati yang diketahui etiologinya atau terkait kelainan sistemik maupun kelainanmiokardium khusus lainnya.2 Penegakan diagnosis KM dan klasifikasinyadidasarkan pada penilaian morfologi dan fungsi jantung.3 Penetapan diagnosis KM primer dilakukan dengan mengeksklusi penyakit/kelainan jantung yanglain.4 Seiring pengamatan klinis, perbedaan antara KM primer dan sekunder akan menjadi semakin jelas, karena ditemukannya etiologi pada kasusyang sebelumnya dianggap merupakan kelainan idiopatik.2
Myocardial Bridging: Peran ct dan mri dalam Diagnosis dan Stratifikasi Risiko Sony Hilal Wicaksono
Jurnal Kardiologi Indonesia Vol. 36, No. 2 April - Juni 2015
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v36i2.466

Abstract

PendahuluanMyocardial bridging (MB) adalah anomali kongenital arteri koroner yang paling umum ditemukan. MB adalah bila terdapat sebagian segmen dari arteri koroner yang berjalan epikardial mengambil jalur menukik ke dalam miokard sehingga menciptakan jembatan di atas segmen arteri koroner tersebut. Insidens MB berdasarkan temuan studi-studi otopsi, didapatkan angka terendah adalah 15% dan angka tertinggi 85%.1 Arteri koroner yang paling sering mengalami myocardial bridging adalah Left Anterior Descending (LAD), yang berdasarkan studi-studi didapatkan angka terendah 67% dan angka tertinggi 98% pasien.2,3 MB dikategorikan termasuk varian normal arteri koroner, dan sebagian besar kasus tidak menampilkan gejala, namun terdapat kasus yang menjadi masalah. Gejala dan gambaran elektrokardiografi yang ditimbulkan oleh iskemia pada MB tidak spesifik sehingga sulit dibedakan dengan iskemia akibat aterosklerosis arteri koroner.4 MB menyebabkan kompresi segmen arteri sehingga terjadi perubahan hemodinamika yang mengakibatkan iskemia, sehingga dapat tampil dengan gejala dan tanda khas iskemia seperti angina, atau temuan iskemia miokard berdasarkan uji stres, datang dengan sindrom koroner akut, temuan disfungsi ventrikel kiri, aritmia bahkan hingga kematian jantung mendadak.5Kemaknaan klinis MB yang tidak spesifik dan rentangnya luas mulai dari dianggap varian normal hingga dapat fatal menjadikan MB perlu mendapatkan perhatian di awal untuk mendapatkan data diagnosis anatomi MB kemudian stratifikasi risiko sesuai kemaknaan fisiologis.
Factors Influencing Mortality of Thoracic Aortic Surgery in The Third World Country Diansari, Rienna; Aligheri, Dicky; Herlambang, Bagus; Wicaksono, Sony Hilal; Mendel, Brian; Yaniarti, Dian; Alkatiri, Amir Aziz; Andriantoro, Hananto; Adiarto, Suko
Jurnal Kardiologi Indonesia Vol 44 No 2 (2023): Indonesian Journal of Cardiology: April - June 2023
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1494

Abstract

Background: A prominent increase of overall global death rate of aortic disease is seen on developing country, with South-east Asia having the highest increase of 41%. Lack of identification and prompt management of the diseases in conjunction with lack of facilities in third world countries that could perform aortic surgery made the procedure more complex when the patients admitted to tertiary hospitals Methods: The data was obtained through medical record of patients underwent thoracic aortic surgery from 2018 to 2021 in National Cardiovascular Center Harapan Kita (NCCHK). One-year and 3-year survival analysis was obtained through phone calls and digital messages. Statistical analysis was done to investigate the impact of surgical complexity as the main predictor and other variables on primary (in-hospital mortality) and secondary (mid-term survival) outcome. Results: A total of 208 patients were included in the analysis; 157 (75,5%) underwent complex surgery, and 51 (24,5%) underwent non-complex surgery. In-hospital mortality was similar across 2 groups (23,6% vs 13,7%; p = 0,1240). On multivariable analysis, malperfusion syndrome (OR 3,560; p = 0,002), CPB duration > 180 minutes (OR 4,331; p = 0,001), and surgical priority (urgent OR 4,196; p = 0,003; emergency OR 10,879; p = 0,001) were identified as independent predictor of in-hospital mortality. Cox regression identified diabetes (HR 4,539; p = 0,025) and emergency procedure (HR 9,561; p = 0,015) as independent predictors for 1-year mortality, and diabetes (HR 3,609; p = 0,004), aortic dissection (HR 2,795; p = 0,029), and maximum aortic diameter (HR 1,034; p = 0,003) for 3-year mortality. Surgical complexity was not associated with early and mid-term mortality. Conclusions: In patients undergoing thoracic aortic surgery, surgical complexity was not associated with early and mid-term survival. Early and mid-term survival was largely determined by patient comorbidities and intra-surgery factors.This article has a related Erratum.
Consensus Statements on the Use of High-Sensitivity Troponin I as the Assessment of Cardiac Risk in Apparently Healthy Population in Indonesia Ambari, Ade Meidian; Ng, Sunanto; Rejeki, Vidya Gilang; Rina Artha, I Made Junior; Raynaldo, Abdul Halim; Alsagaff, Mochamad Yusuf; Wicaksono, Sony Hilal; Dwiputra, Bambang; Desandri, Dwita Rian
Jurnal Kardiologi Indonesia Vol 44 No 3 (2023): Indonesian Journal of Cardiology: July - September 2023
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1544

Abstract

Cardiovascular disease (CVD) is a growing burden in Indonesia, making primary prevention of utmost importance. High sensitivity cardiac troponin I (hsTnI) has been known as one of the biomarkers of choice for diagnosing acute myocardial infarction. Nonetheless, recent studies indicate that hsTnI assay has potential as a predictor of cardiac risk in asymptomatic individuals. An advisory board consisting of renowned cardiologists from the Indonesian Heart Association was convened in Jakarta in March 2023. The meeting aimed to explore the appropriate use of hsTnI for cardiovascular (CV) risk stratification in apparently healthy adults in Indonesia. The board reviewed relevant literature and developed key consensus statements, including hsTnI cut-off for identifying high-risk asymptomatic patients, the proposed algorithm, and monitoring after aggressive risk factor control. This article presents the resulting consensus statements to provide clinicians with a practical tool for planning primary prevention strategies. Furthermore, it is expected to raise awareness and advocacy among stakeholders in the healthcare infrastructure regarding the use of hsTnI as a guide for assessing CV risk in Indonesia.
Coronary Atherosclerotic Calcification Sony Hilal Wicaksono; Christian Setiawan; Indah Fitriani
MEDICINUS Vol. 37 No. 3 (2024): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/00pm8d52

Abstract

Coronary artery disease is a significant public health concern in Southeast Asia, including Indonesia. It is characterized by the buildup of atherosclerotic plaques within the coronary arteries, leading to reduced or interrupted blood flow to myocardium. A hallmark of atherosclerosis is calcification, which may occur during both plaque progression and regression. To date, it remains unclear whether the progression of atherosclerotic lesions follows a linear pattern. The formation of microcalcifications initiates the calcification process and warrants further investigation. Several imaging modalities, which have significantly advanced, may help measure the coronary artery calcification burden and guide appropriate management. Concerns about radiation exposure have positioned coronary artery calcium scoring as the most effective,efficient, and readily observable parameter among both invasive and non-invasive imaging techniques. Identifying highrisk plaque characteristics and severe or extensive calcification is essential in order to provide optimal treatment. However, the progression of calcification remains uncertain, and ongoing research is being conducted to explore potential methods to reverse it. Various tools and complex techniques have been developed to address different types of calcified lesions. Further studies are needed to identify patients who experience more rapid calcification progression, in order to optimize preventive strategies.
Does Chronic Inflammation Play a Role in Rheumatic Mitral Valve Restenosis after Percutaneous Transvenous Mitral Commissurotomy? Butarbutar, Maruli; Soesanto, Amiliana M.; Firman, Doni; Ariani, Rina; Alkatiri, Amir Aziz; Wicaksono, Sony Hilal
Jurnal Kardiologi Indonesia Vol 43 No 3 (2022): Indonesian Journal of Cardiology: July - September 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1398

Abstract

Background: Mitral valve restenosis is defined as decreased mitral valve area (MVA) <1.5 cm2 or decreased MVA >50% after PTMC. It is time-dependent and associated with major adverse cardiovascular events (MACE), such as congestive heart failure, cardiac death, mitral valve replacement, and redo PTMC. The mechanism is not yet known; however, chronic inflammation may have a role. This research aims to determine the association between chronic inflammation and mitral valve restenosis after PTMC. Methods: A total of 40 patients with mitral valve stenosis who underwent successful PTMC were matched and classified into restenosis/case group (n=20) and no restenosis/control group (n=20). Secondary data was taken from electronic medical records such as patient characteristics (gender, age & 2nd prophylaxis), echocardiography data before PTMC (Wilkins’ score and MVA before PTMC), and echocardiography data after PTMC (MVA after PTMC). Follow-up echocardiography examination (follow-up MVA) and laboratory assessment of chronic inflammation marker (IL-6) were done on all patients. Statistical analyses were done to look for an association between the level of chronic inflammation marker & other independent variables with mitral valve restenosis. Results: Median IL-6 concentration was 2.39 (0.03 – 11.4) pg/mL. There was no statistically significant difference in IL-6 levels between both groups (p-value >0.05). MVA decrement was 0.13 (0 – 0.62) cm2/year with rate of MVA decrement ≥0.155 cm2/year was predictor of mitral valve restenosis (p-value <0.001, OR = 46.72, 95% CI 6.69 – 326.19). Conclusion: Chronic inflammation assessed by IL-6 was not associated with mitral valve restenosis.This article has a related Erratum.
The Efficacy of Statin on Coronary Artery Calcification based on Agatston Score: An Updated Meta-analysis of Randomized Control Trials Sony Hilal Wicaksono; Yusra Pintaningrum; Ketut Angga Aditya Putra Pramana
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.10221

Abstract

The purpose of this study is to assess the efficacy of statin treatment on coronary artery calcifcation (CAC) in patients with asymptomatic coronary artery disease (CAD). For randomized controlled trials (RCTs) that assess the efficacy of statin treatment on CAC in patients with asymptomatic CAD, we searched in PubMed, ScienceDirect, and Cochrane. The included publications were subjected to meta-analyses using Review Manager v5.4. In comparison to control, patients with statistically significant had a lower Agatston score (MD -46.25; 95% CI -56.37 - -36.12; p < 0.00001) and had lower CAC volume (MD -24.36; 95% CI -38.21 - -10.51; p = 0.0006). Statin treatment was also linked to a decreased risk of atherosclerotic cardiovascular disease (ASCVD) events (OR 0.60, 95% CI 0.43-0.83; p = 0.002). According to our meta-analysis, the statin treatment was significant to lowering the Agatston score and CAC volume in patients with aysmptomatic CAD. Statin was also linked to a decreased risk of ASCVD events compared to control
Laporan Kasus Langka Sarkoidosis Jantung dengan Hipertensi Pulmonal Nathania Purnomo; Vito Anggarino Damay; Sony Hilal Wicaksono
Majalah Kedokteran Indonesia Vol 73 No 6 (2023): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.73.6-2024-1019

Abstract

Introduction: Cardiac sarcoidosis (CS) is a rare granulomatous disorder in which white blood cells form clusters on the myocardium. The clinical presentations of CS are varied, as is its etiology. Multiple diagnostic approaches to determine the cause of persistent dyspnea may fail, as cardiac sarcoidosis can mimic many other diseases.Case Report: A 47-year-old woman presented with a sudden onset of dyspnea and a history of chronic thrombo-embolic pulmonary hypertension (CTEPH). Multiple diagnostic approaches were employed, including a CT scan of the thorax with contrast, CT pulmonary angiography, CT coronary angiography, and a Ventilation/Perfusion test, but the results were inconclusive. A Cardiac MRI was ultimately performed, which led to a diagnosis of cardiac sarcoidosis.Case Discussion: The patient had been stable and asymptomatic over the years, despite her history of CTEPH, until she developed a sudden onset of dyspnea. The presence of pitting edema, ECG results, and echocardiography data initially suggested a diagnosis of congestive heart failure. However, tests from the pulmonary system and cardiac coronary were normal. This highlights the elusive nature of cardiac sarcoidosis, which can often go unnoticed and be frequently misdiagnosed. Given the inconclusive results from previous tests, a Cardiac MRI was performed to further characterize the pathology. This led to the findings of Late Gadolinium Enhancement (LGE) and the diagnosis of CS.Conclusion: Cardiac sarcoidosis is a master imitator of many diseases, with patients sometimes presenting with only dyspnea. In such cases, Cardiac MRI plays a pivotal role as a diagnostic test, especially when results from other diagnostic workups are nonspecific.
Co-Authors Aligheri, Dicky Alsagaff, Mochamad Yusuf Ambari, Ade Meidian Amiliana M Soesanto Amiliana M. Soesanto Amir Aziz Alkatiri Amir Aziz Alkatiri Amir Aziz Alkatiri Anwar Santoso Aprivita Gayatri Ariani, Rina Ario Soeryo Kuncoro Asmoko Resta Permana Badai Bhatara Tiksnadi Bagus Herlambang Bagus Herlambang Brian Mendel Butarbutar, Maruli Christian Setiawan Citra Primasari Desandri, Dwita Rian Dian Yaniarti Diansari, Rienna Dicky Aligheri Doni Firman Donny Setyawan Syamsul Dwiputra, Bambang Dwita Rian Desandri Erika Adam Erwinanto Erwinanto Fachmi Ahmad Muslim Hananto Andriantoro Hananto Andriantoro Indah Fitriani Irnizarifka Ketut Angga Aditya Putra Pramana Magma Purnawan Putra Manoefris Kasim Maruli Butarbutar Mendel, Brian Nathania Purnomo Raynaldo, Abdul Halim Rejeki, Vidya Gilang Renan Sukmawan Rienna Diansari Rina Ariani Rina Artha, I Made Junior Rita Zahra Suko Adiarto Sunanto Ng Sunanto Ng Teuku Heriansyah Vienna Rossimarina Vito Anggarino Damay Yaniarti, Dian Yusra Pintaningrum Yusra Pintaningrum