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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Cardiology Heart Science Journal
Zulfikri Mukhtar
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Health Professions Immunology & microbiology Medicine & Pharmacology

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Resolution of ST-Segment Depression In Reciprocal Leads As Predictor Mayor Adverse Cardiac Event For ST-Segment Elevation Myocardial Infarction With Fibrinolytic Therapy Aldino Satria Adhitya; Andika Sitepu; Zulfikri Mukhtar; Harris Hasan
Jurnal Kardiologi Indonesia Vol 39 No 2 (2018): Indonesian Journal of Cardiology: April-June 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i2.735

Abstract

Background: ST Elevation Myocardial Infarction (STEMI) may cause Major Cardiovascular Event (MACE). Revascularization needs to be done in all STEMI patients to restore coronary blood flow, hence saving myocardial perfusion. ST Segment Depression (STSD) in reciprocal ECG lead is associated with poor prognosis in STEMI patients receiving fibrinolytic therapy. The main purpose of this study is to evaluate MACE in STEMI patients receiving fibrinolytic therapy using resolution in STSD. Methods: This cohort prospective study with 60 subjects of STEMI patients which are evaluated for MACE (death, heart failure, and rehospitalization) within 30 days after myocardial infarction. Resolution in STSD is defined as resolution ≥ 50% STSD in reciprocal leads within 90 minutes after fibrinolytic therapy.Results: Bivariate analysis showed that Ejection fraction (EF) <40% with OR 8,32 (2,11-32,74), p=0,001; smoking with OR 4,17 (1,05-16,57), p=0,034; Anterior STEMI with OR 3,94 (1,11-13,90), p= 0,027; Creatinine > 1,97 mg/dl with OR 3,69 (1,18-11,55), p= 0,022; complete outpatient medication with OR 5,23 (1,61-17,01), p= 0,004; fragmented QRS with OR 5,23 (1,61-17,01), p= 0,001; resolution in STSD with OR 26,35 (5,16-134, 40), p=<0,001; resolution in ST Segment Elevation with OR 10,5 (2,97-37,24), p=<0,001; are proven to be determining factor for MACE within 30 days. Multivariate analysis showed that among those determining factors for MACE, resolution in STSD on reciprocal leads is evidently the most dominant factor for predicting MACE within 30 days in STEMI patients receiving fibrinolytic therapy [OR 11.47 (1.14-115.10), p=0.038].Conclusion: There is significant difference in MACE within 30 days after myocardial infarction (MI) between patients with and without resolution in STSD. The subjects without resolution in STSD showed higher MACE incidence. Resolution in STSD is evidently an independent predictor for MACE within 30 days after myocardial infarction in STEMI patients.Keywords: Resolution in STSD, MACE, STEMI, Fibrinolytic
Perbandingan faktor resiko aorta abdominal dilatasi pada penderita penyakit jantung koroner dengan menggunakan ekokardiografi Yuke Sarastri; Andre Pasha Ketaren; Nizam Akbar; Sutomo Kasiman; Zulfikri Mukhtar; Tengku Winda Ardini; Rosmaliana dr; Abdullah Afif Siregar
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background : Patients with coronary artery disease share common risk factors as abdominal aortic aneurysm (AAA), in which screening for AA dilatation is recommended. Transthoracic echocardiography (TTE) may offer the opportunity to evaluate the cardiac function and to screen for AA dilatation during the same examination.Aims : This study aimed to compare risk factors for abdominal aortic dilatation with abdominal aorta index in patients with coronary artery disease, and to evaluate the feasibility of AA dilatation screening at bedside using TTE in population with CAD. Methods : This is a cross-sectional study of patients with CAD. The abdominal aortic was measured at the end of a regular TTE performed in consecutive patients admitted in coronary care unit of Haji Adam Malik Hospital Medan using an echocardiography machine.Results : We enrolled 75 patients with mean age 56 (SD 10) years. Dilatation of abdominal aortic was observed in 21 patients (28%). From the analysis obtained a significant relationship between history of acute myocardial infarction with dilatation abdominal aorta (P = 0.04).Conclusion : Overall, the prevalence of dilatation of abdominal aortic increased with age and history of AMI. In regard to the simplicity, screening for AA dilatation during TTE may be of value for patients with CAD, especially in elder patients. Keywords : echocardiography; dilatation of abdominal aortic; coronary artery disease
Correlation between iron profile and severity of coronary artery lesion in patients with non-ST segment elevation myocardial infarction Syarifuddin, Fairuz; Andika Sitepu; Abdullah Afif Siregar; Zulfikri Mukhtar; Cut Aryfa Andra; Teuku Bob Haykal; Harris Hasan
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.12

Abstract

BACKGROUND: Excessive iron has been shown to increase the atherosclerosis process through the help of non-transferrin-bound iron (NTBI). OBJECTIVE: This study aimed to ascertain the association between iron profile and the severity of coronary artery lesions in patients with acute non-ST segment elevation myocardial infarction (NSTEMI).  METHOD: This observational analytical study with a cross-sectional design was conducted from February to September 2024 at Adam Malik General Hospital. NSTEMI patients planned for coronary angiography were examined for iron profile, including serum iron, total iron binding capacity (TIBC), and transferrin saturation. Coronary artery lesion severity was evaluated using the synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score.  RESULTS: This study involved 72 subjects. The results showed there were no correlations between serum iron levels and SYNTAX scores (p = 0.891) and transferrin saturation with SYNTAX scores (p = 0.545). Nevertheless, TIBC and SYNTAX score were negatively correlated (p = 0.004) with a weak correlation coefficient (r = -0.334).  CONCLUSION: TIBC levels are inversely correlated with the severity of coronary artery lesions. However, transferrin saturation and serum iron have not been shown to correlate with the severity of coronary artery lesions.
Co-Authors Abdullah Afif Siregar Aldino Satria Adhitya Andre Pasha Ketaren Cut Aryfa Andra Harris Hasan Nizam Akbar Rosmaliana dr Sitepu, Andika Sutomo Kasiman Syarifuddin, Fairuz Tengku Winda Ardini Teuku Bob Haykal Yuke Sarastri