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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Cardiology Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Andre Pasha Ketaren
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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A Significant Addition of Left Ventricular Fractional Shortening to Ejection Fraction correlated with Global Longitudinal Strain Value in Predicting Major Acute Cardiovascular Event in patients with Acute Coronary Syndrome Bertha Gabriela Napitupulu; Harris Hasan; Nizam Z Akbar; Andre Pasha Ketaren; Zainal Zafri; Ali Nafiah Nasution
Jurnal Kardiologi Indonesia Vol 41 No 4 (2020): Indonesian Journal of Cardiology: October - December 2020
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1069

Abstract

Background: Global longitudinal strain (GLS) was a proven predictor of systolic function improvement and myocardial remodeling after acute coronary syndrome (ACS) for a residual left ventricular function defined their prognosis. However, not all echocardiography devices are equipped by speckle tracking (STE) as compare to the availability of M-mode modality which capable on assessing fractional shortening (FS) instead. Methods: This study evaluated clinical and echocardiography parameters on myocardial infarction (MI) and non-MI ACS patients. Clinical outcome was defined as composite major acute cardiovascular event (MACE) on 6 months of follow up. Results: Over 145 patients, GLS>-9.4% was found to be an independent predictor of MACE despite of troponin, age, ejection fraction (EF), prior reperfusion and infarct location [(HR 5.89 (1.82-16.51)]. There is negative correlation between FS and GLS (Spearman r -0,717; p<0,01). By using logistic regression analyses, it was found that the addition of FS<25% to biplane Simpson EF<50% could be useful to rule in the presence of GLS>-9.4% (AUC 0.831). Conclusion: GLS had a prognostic value in patients with ACS. Left ventricular conventional M-mode FS in addition to Simpson EF were well correlated with GLS as well they can be considered as an alternative in predicting the incident of MACE in patient with ACS. Keywords: global longitudinal strain, prognostic, fractional shortening, acute coronary syndrome
THE DIFFERENCE OF PLASMA D-DIMER LEVELS IN ACUTE MYOCARDIAL INFARCTION WITH AND WITHOUT ST ELEVATION Desi Kharina Tri Murni; Adi Koesoema Aman; Andre Pasha Ketaren
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1140

Abstract

D-dimer terlibat di tahap awal patofisiologi proses Infark Miokard Akut (IMA). Kenaikan Kadar D-dimer di IMA mencerminkanadanya trombosis. Penelitian ini bertujuan untuk mengetahui perbedaan kadar D-dimer plasma di IMA dengan ST elevasi dan tanpaST elevasi. Penelitian ini berupa analitik observasional dilakukan secara potong lintang di Instalasi Gawat Darurat RSUP. AdamMalik Medan, masa waktu bulan April–September 2015. Sampel dikelompokkan menjadi 2 kelompok yaitu sampel dengan diagnosaNSTEMI berjumlah 18 sampel dan sampel dengan diagnosa STEMI berjumlah 18 orang. Semua sampel diperiksa Kadar D-dimer plasma.Penelitian ini menunjukkan ada perbedaan kadar D-dimer plasma di IMA dengan ST elevasi (STEMI) dan tanpa ST elevasi (NSTEMI)yaitu kadar D-dimer di kelompok NSTEMI adalah 440,39±209,33 dan kelompok STEMI adalah 654,89±229,88 (nilai p<0,05). Kadarrerata D-dimer di kelompok STEMI lebih tinggi daripada kadar D-dimer di kelompok NSTEMI.
Perbandingan faktor resiko aorta abdominal dilatasi pada penderita penyakit jantung koroner dengan menggunakan ekokardiografi Yuke Sarastri; Andre Pasha Ketaren; Nizam Akbar; Sutomo Kasiman; Zulfikri Mukhtar; Tengku Winda Ardini; Rosmaliana dr; Abdullah Afif Siregar
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 3 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background : Patients with coronary artery disease share common risk factors as abdominal aortic aneurysm (AAA), in which screening for AA dilatation is recommended. Transthoracic echocardiography (TTE) may offer the opportunity to evaluate the cardiac function and to screen for AA dilatation during the same examination.Aims : This study aimed to compare risk factors for abdominal aortic dilatation with abdominal aorta index in patients with coronary artery disease, and to evaluate the feasibility of AA dilatation screening at bedside using TTE in population with CAD. Methods : This is a cross-sectional study of patients with CAD. The abdominal aortic was measured at the end of a regular TTE performed in consecutive patients admitted in coronary care unit of Haji Adam Malik Hospital Medan using an echocardiography machine.Results : We enrolled 75 patients with mean age 56 (SD 10) years. Dilatation of abdominal aortic was observed in 21 patients (28%). From the analysis obtained a significant relationship between history of acute myocardial infarction with dilatation abdominal aorta (P = 0.04).Conclusion : Overall, the prevalence of dilatation of abdominal aortic increased with age and history of AMI. In regard to the simplicity, screening for AA dilatation during TTE may be of value for patients with CAD, especially in elder patients. Keywords : echocardiography; dilatation of abdominal aortic; coronary artery disease
Perbedaan kadar interleukin-6 pada pasien dengan dan tanpa stenosis koroner signifikan Fatiah dr; Ratna Akbari Ganie; Andre Pasha Ketaren
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 2 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Introduction : Coronary heart disease (CHD), characterized by coronary arteries stenosis, is the end result of atherosclerosis. Interleukin-6seems to be the key point in process of atherosclerosis.The aim of this study is to find out whether there is a difference between serum Interleukin-6 level in patients with and without significant coronary stenosis.Methods : A cross-sectional observational analytic study was performedto 34 patients with suspected CHD that underwent coronary angiographyin H.Adam Malik hospital, Medan from February- April 2016.Patients were divided into 2 groups, 17 patients with significant coronarystenosis and 17 patients without significant coronarystenosis.Serum Interleukin-6 level were measured.Results : The medianvalue of serum Interleukin-6 levelin patients with significant coronarystenosis was 14.7 pg/mLand patients without significant coronarystenosis was 12.62pg/mL. There was no significant difference between serum Interleukin-6 level in patients with and without significant coronary stenosis ( p=0.301).Conclusion : There was no significant difference between serum Interleukin-6 level in patients with and without significant coronary stenosis.Keywords : Interleukin-6, Atherosclerosis, CHD
Co-Authors Abdullah Afif Siregar Adi Koesoema Aman Ali Nafiah Nasution Bertha Gabriela Napitupulu Desi Kharina Tri Murni Fatiah dr Harris Hasan Nizam Akbar Nizam Z Akbar Ratna Akbari Ganie Rosmaliana dr Sutomo Kasiman Tengku Winda Ardini Yuke Sarastri Zainal Zafri Zulfikri Mukhtar