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All Journal Jurnal Kedokteran Mulawarman The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Mangalindung Ompusunggu
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Gastrointestinal Bleeding, Jejunum Perforation and Intussusceptions Ileo-Jejunal Segment with Multiple Polyposis Due to Metastasic Melanoma with Out Primary Cutaneus Melanoma? Lianda Siregar; Mangalindung Ompusunggu
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 5, ISSUE 3, December 2004
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/532004105-108

Abstract

Approximately 60% of patients who die due to melanoma have gastrointestinal metastases at autopsy, yet ante mortem diagnosis is uncommon. The small bowel is the most frequent intestinal site of metastasis and prognosis is very poor with a median survival after operation was 6.2 months (range: 1–42 months). Bowel metastases may appear radiologically as polypoid mucosal lesions, submucosal nodules, diffuse infiltration with thickening of the intestinal wall, or serosal implants. Bowel obstruction due into intussusceptions is common clinical presentation of gastrointestinal metastasis; other presentation include gastrointestinal bleeding, perforation and large masses.We reported a case of metastatic melanoma to small bowel, whose had hematemesis melena, abdominal pain, diarrhea and weight loss without primary cutaneus melanoma. Gastroduodenoscopy appeared normal. The ultrasonography of bowel showed a”doughnut” configuration with concentric rings of bowel wall. Left lateral decubitus abdominal radiographies showed free air appearances. Laparatomy reported three location of invagination (intussuception) with multiple polyposis at ileo–jejunal segment (29 pieces of polyp) and jejunum perforation. Resection and end–to end anastomosis of the affected segment had been performed with no serious complication after this. Miscroscopical examination of specimen showed metastatic melanoma malignant in 3 lymph nodes. Eight weeks later patients died with distant metastases to brain. Keywords:  Intussesception and perforation, multiple polyposis, metastase melanoma without primary cutaneus melanoma
Management of Patients with Gastrointestinal Stromal Tumor (GIST) : Serial Case Report Munir, Sirajul; Ompusunggu, Mangalindung; Suprapto, Bambang
Jurnal Kedokteran Mulawarman Vol 11, No 2 (2024): Jurnal Kedokteran Mulawarman
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v11i2.10444

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. These are rare representing approximately 0.1-3% of all GI. The management of GIST is carried out using a multidisciplinary approach. Standard treatment of localized GIST is complete surgical resection associated (or not) with adjuvant Imatinib therapy. We reported 4 cases of GISTs with different management. We performed the surgical excision in three female patients with a median age of 44.7 years and 1 male patient get neoadjuvant imatinib due to unresectable mass. In our series, clinical manifestations are variable among patients, abdominal discomfort is the most primary symptoms. All of our patients received one year of Imatinib 400 mg daily therapy after the surgery and follow up based on Algorithm Treatment For GISTs.
Co-Authors Lianda Siregar Sirajul Munir Suprapto, Bambang