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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science)
Indah Putri Arwandi
Fakultas Kedokteran Universitas Riau
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Efek Inhibitor Proteasom Terhadap Gambaran Histopatologi Jantung pada Tikus yang diinduksi Aterosklerosis Ilhami Romus; Ismawati Ismawati; Indah Putri Arwandi
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.66-70

Abstract

Proteasome inhibitors are compounds that can inhibit the proteasome pathway in carrying out its functions. Proteasome inhibitors have a beneficial effect due to their anti-inflammatory properties. The proteasome inhibitor used in this study was bortezomib. This study aimed to analyze the effect of proteasome inhibitors on cardiac histopathology in atherosclerosis-induced rats. This study used male Rattus novergicus Wistar strain which was divided into 3 groups, namely the control group, the atherosclerosis-induced group and the atherosclerosis-induced group and given bortezomib. The results obtained the mean scores of edema, inflammation and necrosis in the atherosclerosis group were given bortezomib at a dose of 50 g/kgBW were less than the atherosclerosis group. Theese difference were statistically significant  (p<0.05). This study concluded that the administration of bortezomib can reduce the Impact of atherosclerotic lesions on the heart muscle.
Co-Authors Ilhami Romus Ismawati ismawati