Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

1.8

P-Index

This Author published in this journals

All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Jurnal Kedokteran Brawijaya Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Gizi Klinik Indonesia Jurnal Kedokteran dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat International Journal of Basic and Applied Science Jurnal Katalisator Media Penelitian dan Pengembangan Kesehatan

Ismawati ismawati

Universitas Riau

Author-ID : 919902

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

Published : 14 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

Effect of Bortezomib on Total Cholesterol, Triglycerides and Histopathology Abdominal Aorta in Rats of Atherosclerosis Model Ismawati, Ismawati; Romus, Ilhami; Maryanti, Esy; Permatasari, Nopi; Luthfianty, Elfiah
Jurnal Kedokteran Brawijaya Vol 31, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.02.5

The effects of using proteasome inhibitors on atherosclerosis could be beneficial or detrimental. This study aimed to analyze the effects of proteasome inhibitors in the progression stage. Experimental animals (18 rats) were divided into three groups, namely control (C) as a group of rats given standard feed, P1 as atherosclerosis-induced rat group, and P2 as atherosclerosis-induced rat group and given proteasome inhibitors. Proteasome inhibitor administered was bortezomib at a dose of 50Âµg/kgBW/day intraperitoneally on day 1 and 3. After four days of treatment, the termination and measurement of serum total cholesterol, serum triglycerides, and abdominal aorta histopathology with hematoxylin-eosin staining were carried out. Serum total cholesterol levels were measured using the CHOD-PAP (Cholesterol Oxidase-Peroxidase Aminoantypirin) method, whereas serum triglyceride levels were measured using the GPO-PAP (glycerol phosphatase oxidaseâˆ’phenol4-amino antipyrene peroxidase) method. Histopathological assessment was carried out with a scoring system in 9 fields of view with a 400x magnification, which was then averaged. The ANOVA test showed significant differences in serum total cholesterol, serum triglycerides, and abdominal aortic histopathology between atherosclerosis and control groups, but there were no significant differences in the administration of bortezomib in atherosclerosis except in serum triglyceride levels. It can be concluded that the administration of 50Âµg/kg bortezomib for four days in the rats model of the progression stage of atherosclerosis can decrease serum triglyceride levels, although it can not inhibit the formation of atherosclerotic lesions and has no effect on serum total cholesterol.Â

Efek Pemberian Asam Alfa Lipoat pada Histopatologi Aorta Torakalis Tikus Diabetes Melitus Tipe 2 Rijalun Arridho; Ismawati Ismawati; Enikarmila Asni; Ilhami Romus
Jurnal Ilmu Kedokteran Vol 14, No 1 (2020): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v14i1.2020.33-38

Atherosclerosis is arterial wall’s disease initiated by lipid retention, oxidation, and modification, provoking chronic inflmmation ultimately causing stenosis and thrombosis. This study investigated the effect of alpha lipoic acid (ALA) on thoracic aorta type 2 diabetic rat. Fifteen adult male rat of Rattus novergicus Wistar strain were separated into three groups (n=5), there were labelled as control, type 2 diabetes (DM), and DM + ALA. Type 2 diabetic rats were induced by streptozotocin (50 mg/kg bodyweight) and nicotinamide (110 mg/kg bodyweight) and categorized as diabetic rat if blood glucose level >250 mg/dl. Alpha lipoic acid was administered via intraperitoneal (60 mg/kg/day) and conducted for 3 weeks. The measured parameter was atherosclerosis lesion score. Results showed that there was no significant difference in atherosclerosis lesion scores between all groups designed (p=0,071). It can be concluded that ALA did not have a significant effect on atherosclerosis lesion of thoracic aorta type 2 diabetic rat.

Pengaruh Asam Alfa Lipoat Terhadap Kadar Trigliserida pada Tikus Diabetes Melitus Tipe 2 Angel Chen; Ismawati Ismawati; Enikarmila Asni
Jurnal Ilmu Kedokteran Vol 12, No 1 (2018): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Accumulation of triglycerides associated with insulin resistance in type 2 diabetes mellitus (T2DM). Alpha lipoic acid (ALA) has hypotriglyceridemic effects by lowering triglyceride levels in blood and liver. This study aims to analyze effect of ALA on triglyceride levels in type 2 diabetic rats. Fifteen Wistar male rats (±8-12 weeks, 200-250 gram) divided into 3 groups (control, T2DM and T2DM–ALA given for 3 weeks). Diabetes was induced by giving streptozotocin (50 mg/kg.bw) and nicotinamide (110 mg/kg.bw) after 15 minutes intraperitoneally. Diagnosis of T2DM was determined if the rats have perifer blood glucose >250 mg/dL after 3 days. The results showed that triglyceride levels in ALA group (p=0,003) lower than T2DM group, T2DM group (p=0,031) had higher triglyceride level than control and no difference of triglyceride level between T2DM-ALA given group with control (p=0,696). This study concluded that ALA can affect triglyceride levels in T2DM thus prevents occurrence of hypertriglyceridemia.

Gambaran Sarapan dan Status Gizi Pada Mahasiswa Fakultas Kedokteran Universitas Riau Angkatan 2017 Isnani Kurniyanti; Erwin Christianto; Ismawati Ismawati
Jurnal Ilmu Kedokteran Vol 12, No 2 (2018): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Breakfast is an activity of eating and drinking between waking up to 9 am to fulfill some of the daily nutritional needs (15-30% nutritional needs). The benefits of breakfast are maintaining an ideal body weight because breakfast can reduce the amount of food you eat throughout the day. The purpose of this study was to find out the description of breakfast and Body Mass Index (BMI) in students of the Faculty of Medicine, University of Riau in 2017. This research was descriptive study with 121 samples. The results showed 16.3% obese I and 8.1% obese II. Respondents with good breakfast calories tend to have good nutritional status of 50.0%.

Alpha Lipoic Acid Inhibits Expression of Intercellular Adhesion Molecule-1 (ICAM-1) in Type 2 Diabetic Mellitus Rat Models Ismawati Ismawati; Enikarmila Asni; Mukhyarjon Mukhyarjon; Ilhami Romus
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.906

BACKGROUND: Diabetes mellitus (DM) is associated with an accelerated atherosclerotic macrovascular disease affecting medium-sized arteries. Several evidences support the role of oxidative stress in atherogenesis. However, the role of alpha lipoic acid (ALA) to prevent atherosclerosis is still debatable. This study was conducted to determine the effect of 60 mg/kg/day ALA for 21 days toward the expression of intercellular adhesion molecule-1 (ICAM-1) in rat model.METHODS: Eighteen male rats were divided into three groups labelled as control group, type 2 DM (T2DM) group, and T2DM+ALA group. The T2DM rat models were created by intraperitoneally injecting 50 mg/kg streptozotocin, followed by 110 mg/kg nicotinamide. Immunohistochemistry was used to evaluate the ICAM- 1 expression in rats. Quantitative image analysis of immunohistochemical stains was done on the abdominal aorta using Adobe Photoshop CS3 to find the area percentage and intensity. Kruskal-Wallis and Mann-Whitney tests were used to compare the mean value of area percentage and intensity.RESULTS: There was an increase in area percentage and intensity of ICAM-1 expression. The highest area percentage of ICAM-1 expression was found in the DM group, while the lowest was found in the control group. There were significant differences in the area percentage and intensity between DM+ALA group and DM group, where the area percentage and intensity of ICAM-I in DM group was higher than the DM+ALA group.CONCLUSION: In conclusion, our results demonstrate that ALA inhibits the expression of ICAM-1 in T2DM rat models.KEYWORDS: atherosclerosis, ICAM-1, alpha lipoic acid

Deteksi Hiperkolesterolemia pada Masyarakat Kota Siak Sri Inderapura Ismawati Ismawati; Imelda Tresia Pardede
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 5 No 3 (2020): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Coronary heart disease (CHD) is a disorder caused by the process of atherosclerosis in the coronary arteries which results in disruption of blood flow to the heart muscle. Various attempts have been made to control CHD but have not given optimal results. One of the basic steps in controlling is to do a health screening that is checking blood cholesterol. The purpose of this service activity is to improve the control of CHD risk factors by detecting hypercholesterolemia so that it is expected to reduce the incidence of CHD. The program was carried out in collaboration with Siak District Hospital and Siak branch IDI. Prospective service participants register online and fill in data in the form of the name, gender, age, address, occupation, height, and weight. On the day of the activity, participants were re-registered. Next is a blood cholesterol check and education about hypercholesterolemia and its management. The effort to detect hypercholesterolemia and education in the Sri Inderapura Siak City community was carried out in August 2019 at the Tengku Maharatu Building. Measurement of community cholesterol levels is done by using a digital inspection tool. On examination found that most participants had normal total cholesterol levels which were 55.94%, while hypercholesterolemia was found in 26 participants (44.06%).

Efek asam alfa lipoat terhadap insulitis pada tikus diabetes melitus tipe 2 Ismawati Ismawati; Mukhyarjon Mukhyarjon; Ilhami Romus; Sonia Dinda Paramitha
Jurnal Gizi Klinik Indonesia Vol 16, No 2 (2019): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Effect of alpha lipoic acid on insulitis in type 2 diabetic ratBackground: The damaging of β cell causes hyperglycemia. Β cell damaged as insulitis happens because of the increase of free radical and the decrease of endogen antioxidant that caused oxidative stress.Objective: The goal of this research was to find out the effect of alpha lipoic acid (ALA) on pancreas Langerhans island’s histopathology in type 2 diabetic rats.Methods: This was an experimental laboratory study with post test only design. Fifteen adult male rats of Wistar strain were segregated into three groups (n=5) labeled as control, type 2 diabetes (DM), and DM+ALA. The experiment was designed for 3 weeks. The measured parameter was insulitis level on pancreas Langerhans island of groups labeled.Results: The statistical test result showed there was the significant difference between control and type 2 diabetes group (p=0,005), but there was no significant difference between DM and DM+ ALA group (p=0,549).Conclusions: Although not statistically significant, giving ALA 60 mg/kg body weight for 3 weeks decreased the degree of insulitis in diabetic rats.

Efek Inhibitor Proteasom terhadap Histopatologi Arteri Koronaria pada Tikus Model Aterosklerosis Ismawati ismawati; Ilhami Romus; Elfima Aditya Utami
Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2020): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/jkk.16.2.135-142

Penelitian sebelumnya menunjukkan peranan proteasom pada setiap tahap aterosklerosis yaitu tahap inisiasi, progresi dan komplikasi. Hal ini mendorong penelitian inhibitor proteasom sebagai terapi aterosklerosis dan bortezomib merupakan inhibitor proteasom yang pertama kali dikembangkan. Pada penelitian ini akan dianalisis efek pemberian inhibitor proteasom (bortezomib) terhadap pembentukan lesi aterosklerosis pada arteri koronaria tikus model aterosklerosis tahap progresi. Penelitian ini menggunakan 15 ekor tikus (Rattus novergicus) strain Wistar jantan yang dibagi menjadi 3 kelompok yaitu kelompok kontrol (I), kelompok aterosklerosis (II), dan kelompok aterosklerosis dengan pemberian bortezomib (III). Induksi aterosklerosis dilakukan dengan pemberian vitamin D3 (700.000 IU/kg) secara oral, dan dilanjutkan dengan diet aterogenik (kolesterol 2%, lemak kambing 5%, asam kolat 0,2 % dan diet standar 100%) selama 4 hari. Pemberian bortezomib dosis rendah (50 μg/kgBB) pada hari ke-1 dan ke-3 secara intraperitoneal. Penilaian lesi aterosklerosis dilakukan dengan sistem skoring. Hasil penelitian didapatkan skor lesi tertinggi pada kelompok model aterosklerosis dan adanya penurunan rerata skor lesi aterosklerosis pada kelompok aterosklerosis yang diberi bortezomib (0,70 vs 0,44, p<0,05). Disimpulkan bahwa pemberian bortezomib dapat menghambat pembentukkan lesi aterosklerosis pada tahap progresi.

Alpha Lipoic Acid Effect on Collagen of Extra Cellular Matrix β Cell Pancreas in Type 2 Diabetic Rats Ismawati Ismawati; Ilhami Romus; Dhea Ayu Kartini Surya Putri
Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2020): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Kelainan pulau Langerhans (isletopathy) merupakan salah satu komplikasi DM tipe 2. Penelitian mengenai efek asam alfa lipoat (ALA) terhadap matriks ekstraseluler pankreas (ECM) pada DM tipe 2 masih terbatas. Penelitian ini bertujuan untuk mengetahui efek ALA terhadap ketebalan kolagen ECM sel β pankreas pada tikus diabetes melitus tipe 2. Penelitian eksperimental dengan design post test only control group design ini menggunakan 15 ekor tikus Rattus novergicus galur Wistar jantan yang dibagi menjadi tiga kelompok, yaitu kelompok kontrol, kelompok diabetes melitus tipe 2, dan kelompok diabetes melitus tipe 2 yang diberi ALA. Induksi diabetes melitus tipe 2 dilakukan dengan pemberian streptozotosin (50 mg/kgBB) diikuti nikotinamid (110 mg/kgBB) intraperitoneal. Dosis ALA yang digunakan 60 mg/kgBB/hari diberikan selama 3 minggu. Ketebalan kolagen matriks ekstraseluler sel β pankreas dinilai dengan pewarnaan Verhoeff's van Gieson (VvG) dengan sistem skoring. Hasil penelitian menunjukkan ketebalan kolagen matriks ekstraseluler pulau Langerhans pankreas tetap normal pada semua kelompok penelitian. Pemberian ALA 60 mg/kgbb selama 3 minggu pada tikus DM tipe 2 tidak memiliki efek terhadap ketebalan kolagen ECM pankreas. Dengan demikian perlu dilakukan penelitian lanjutan mengenai efek ALA terhadap kolagen matriks ekstra seluler pankreas DM tipe 2 tahap lanjut.

Effects of Proteasome Inhibitor on Catalase Expression and Intima-media Thickness in the Aorta of Atherosclerotic Rats Ismawati Ismawati; Enikarmila Asni; Ilhami Romus; Mukhyarjon Mukhyarjon; Winarto Winarto; Muhammad Fadhillah Arif; M Derillovyandra Dwi Anugrah
Global Medical & Health Communication (GMHC) Vol 10, No 3 (2022)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v10i3.9508

Various studies have been carried out to obtain proper management for atherosclerosis. Proteasome, a subcellular enzyme complex, is a potential therapeutic target for atherosclerosis. However, the effect of proteasome inhibitors on atherosclerosis still needs to be explored. It was an experimental study with a post-test-only control group design conducted at the Faculty of Medicine, Universitas Riau in Juni–November 2021. This study aimed to analyze the effects of proteasome inhibitors on catalase expression and intima-media thickness (IMT) in the thoracic aorta of atherosclerotic rats. Fifteen male Wistar rats were randomly divided into three groups (five rats per group), namely rats given standard feed (control, group I), rats induced atherosclerosis (group II), and rats induced atherosclerosis and given proteasome inhibitor (group III). The proteasome inhibitor, bortezomib, 50 µg/kgBW/day was given intraperitoneally on days one and three. After 4 days, rats were terminated, and the thoracic aorta was taken for the IMT analysis and catalase expression assessment using immunohistochemistry. Catalase expression was carried out quantitatively using Adobe Photoshop software. Analysis of variance test was used to compare the expression of catalase and IMT. A p value<0.05 was considered statistically significant. The results showed a significant decrease in IMT in group III compared to group II and an increase in catalase expression in group III compared to group II but not statistically significant. This study concludes that administration of bortezomib 50 µg/kgBW in atherosclerotic rats could inhibit thickening tunica intima-media in the thoracic aorta, although not significantly increasing the catalase expression.

Co-Authors Angel Chen Dhea Ayu Kartini Surya Putri Dyna, Fitri Edy Fachrial Elfima Aditya Utami Enikarmila Asni Erwin Christianto Esy Maryanti Ilhami Romus Ilhami Romus Ilhami Romus Ilhami Romus, Ilhami Imelda Tresia Pardede Indah Putri Arwandi Isnani Kurniyanti Ligat Pribadi Sembiring Luthfianty, Elfiah M Derillovyandra Dwi Anugrah Muhammad Fadhillah Arif Mukhyarjon Noviardi Noviardi, Noviardi Permatasari, Nopi Putra, Amrullah Syah Rijalun Arridho Saputra, Nicko Pisceski Kusika Saryono Saryono Saryono Sonia Dinda Paramitha Sri Yanti Titania Tjandrawati Nugroho Veni Dayu Putri Winarto Winarto

Title

Found 14 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 14 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 14 Documents
Search