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All Journal Biomolecular and Health Science Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Indonesian Journal of Global Health Research

Budi Widodo

Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo Hospital, Surabaya, Indonesia

Author-ID : 3402013

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Articles

Frequency of Metabolic Syndrome on Diabetes Mellitus Patients in Surabaya Dyah Peni Puspitasari; Budi Widodo; Jongky Hendro Prayitno
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Metabolic syndrome is a syndrome characterized by central obesity, high blood glucose or impaired glucose tolerance, dyslipidemia, and high blood pressure. Nearly 70% to 80% of Diabetes melitus (DM) population was diagnosed with metabolic syndrome. We aimed to present the data of frequency of metabolic syndrome in patients with DM for a basis of future research.Methods: This is a descriptive study design on DM patients based on NCEP ATP III criteria. The data was collected from direct measurements and laboratory results of all DM patients: waist circumference, weight, height, and blood pressure of the subjects, triglyceride status (TG), high-density lipoprotein cholesterol (HDL-C) status, and fasting blood glucose status.Results: From 77 DM patients, results were obtained in this study were 69 (89.61%) patients with DM-metabolic syndrome (DM-MetS) and 8 (10.39%) patients with DM-non-metabolic syndrome. From 69 patients with DM-MetS, 52 (75.36%) were female and 17 (24.64%) were male.Conclusion: A total of 69 (89.61%) patients with T2DM were diagnosed as metabolic syndrome.

Effect of Pneumatic Balloon Dilation to The Changes of Eckardt Score in Patient With Achalasia Budi Widodo; Iswan Abbas Nusi; Titong Sugihartono
Biomolecular and Health Science Journal Vol. 3 No. 1 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i1.17938

Introduction: Achalasia is an esophageal motility disorder, but its pathogenesis remains unclear. The highest incidence is among adults aged 30 – 60 years with the prevalence of 10/100.000 population. Diagnosis of achalasia is based on symptoms and upper endoscopy, barium esophagogram, and esophageal manometry. Pneumatic Balloon Dilation (PBD) is one of the treatment options, whether it is fluoroscopy-guided or direct endoscopy guided. This study aims to analyze the effect of PBD on the changes of Eckardt score among achalasia patients.Methods: An analytical observational study with a retrospective and prospective design was conducted on 18 achalasia patients who performed PBD at Dr. Soetomo General Hospital. Data were then analyzed using t-test. Results: The mean age was 47.8±12.5 years, and the mean achalasia duration was 18.3±5.9 months. There were no differences of achalasia cases between men and women. The mean body weight in the pre and post PBD was 50.9±6.2 vs 53.1±6.5 kg with delta 2.19±1.88 (p <0.0001). The mean BMI in the pre and post PBD was 20.2±2.2 vs 21.1±2.5 kb/m2 with delta 0.89±0.78 (p <0.0001). In addition, the mean Eckardt score in the pre and post PBD was 10.17±1.47 vs 2.5±0.86 (p <0.0001). There were 3 patients with Eckardt score of 4 after PBD and no weight loss after one-month evaluation. Conclusion: There was a significant difference of Eckardt score before and after PBD. The improvement of the Eckardt scores led to the change of weight and body mass index among achalasia patients.

The Association between The Degree of Liver Cirrhosis Severity and Zinc Serum Level Budi Yuwono; Ummi Maimunah; Budi Widodo
Current Internal Medicine Research and Practice Surabaya Journal Vol. 1 No. 1 (2020): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE JOURNAL SURABAYA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v1i1.16996

Background: Impaired liver function in LC (Liver Cirrhosis) can cause Zinc deficiency (Zn). One of the causes of Zn deficiency in LC is decreased albumin synthesis, whereas albumin is required as the main Zn binding protein in plasma. However, some studies of the severity of LC with Zn serum levels still provide controversial results.Objective: To determine the association between the degree of LC severity and Zn serum level.Methods: The subjects of this study were LC patients in Gastroentero-Hepatology Unit and Internal medicine wards in of Dr. Soetomo General Hospital Surabaya for three months. Diagnosis of LC was based on clinical examination according to Soehardjno-Soebandiri criteria and other findings (ultrasound or endoscopy). The degree of LC severity was determined based on the CTP score (Child-Turcotte-Pugh). Serum Zn concentration was measured by atomic absorption spectrophotometry method. The research design used the cross-sectional method. The statistical test used was Spearman correlation.Results: Forty-three patients fulfilled the study criteria. The subjects consisted of 27 males (62.8%) and 16 females (37.2%) with the mean age of 53.81 ± 8.67 years. Based on the CTP scores, we obtained CTP A of 4 patients (9.3%), CTP B of 19 patients (44.2%) and CTP C of 20 patients (46.5%). The mean of Zn serum level in CTP A, CTP B, and CTP C score was 58.3 ± 19.6 μg/dl, 43.4 ± 14.5 μg/dl and 31.6 ± 10 μg/dl respectively. The result of the statistical test showed a significant correlation between LC severity and Zn serum level (p <0.05 and r = -0.583).Conclusion: The heavier the severity of LC, the lower Zn serum levels.

Histoacryl Glue Injection for Treatment in Patient with Gastric Varices Non-cirrhotic Portal Hypertension Jualita Heidy Saputri; Budi Widodo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 19, No 3 (2018): VOLUME 19, NUMBER 3, December 2018
Publisher : The Indonesian Society for Digestive Endoscopy

Upper gastrointestinal bleeding is differentiated based on clinical needs into variceal and non-variceal bleeding. The cause of varices bleeding is portal hypertension, both cirrhosis and non-cirrhosis. Gastric varices occur less than esophageal varices, but the morbidity and mortality rate are high. The following is case report of gastric non-cirrhotic variceal bleeding. The 19-year-old man had hematemesis melena with anemia. After hemodynamic stabilization, GOV 2 gastric varices were found and definitive endoscopic obturation therapy was given by intravarices injection of diluted histoacryl. After the procedure, there were mild and transient side effects, as well as no re-bleeding until the 7th month.

Response Evaluation of Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatocellular Carcinoma with Respect to Tumour Size, Number of Lesion, and Alpha-Fetoprotein (AFP) Level Adaninggar PN; Ulfa Kholili; Ummi Maimunah; Poernomo B Setiawan; Iswan A Nusi; Herry Purbayu; Titong Sugihartono; Budi Widodo; Husin Thamrin; Amie Vidyani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 1 (2016): VOLUME 17, NUMBER 1, April 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Transarterial chemoembolization (TACE) is widely used as a palliative treatment for unresectable hepatocellular carcinoma (HCC). TACE is also used as bridging therapy before liver transplantation to avoid tumour progression and considered for downstaging to fulfill tumour resection or liver transplantation criterias. This study aimed to evaluate response of TACE in unresectable HCC according to changing of tumour size, number of lesion, and AFP level.Method: Retrospectively, we evaluate 69 HCC patients who underwent TACE in Dr. Soetomo General Hospital in January 2012-June 2015, including their age, sex, aetiologies, and Barcelona Clinic Liver Cancer/BCLC staging. Laboratory examinations such as complete blood count (hemoglobin/Hb, leucocyte, thrombocyte), liver function test (aspartate aminotransferase/AST, alanine aminotransferase/ALT, bilirubin, albumin, international normalized ratio/INR), alpha-fetoprotein/AFP level, and abdominal CT-scan were performed before and 1 month post-TACE. Data was analysed using paired t-test.Results: 69 patients with mean age of 51.81 ± 12.8 years old, predominantly 76.8% males, the most common aetiology was hepatitis B 68.1%, 92.8% BCLC B, 64.3% with stable disease, none achieved complete response, 97.1% had tumour size 5 cm, 69.6% had single tumour, and 55.7% had AFP level 1000 ng/mL. There was a significant increase in tumour size and number of lesions in 1 month post-TACE that were approximately 1.76 cm and 2.33, respectively, and there was no significant difference between AFP level before and 1 month post TACE.Conclusion: In 1 month post TACE evaluation, there was a significant increase of tumour size and number of lesion, but there was no significant alteration in AFP level. TACE might be performed repeatedly with shorter evaluation interval than 1 month to achieve better response.

Profile of Esophageal Cancer Management Saskia Andiani; Rizka Fathoni Perdana; Budi Widodo; Puguh Setyo Nugroho
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.743

Esophageal cancer is one of the leading causes of cancer-related mortality worldwide, often diagnosed at an advanced stage with limited therapeutic options. In Indonesia, particularly at Dr. Soetomo General Hospital Surabaya, data regarding esophageal cancer treatment remain limited. A better understanding of treatment profiles and patient characteristics is essential to improve clinical outcomes and develop early detection strategies. To analyze the profile of esophageal cancer treatment at Dr. Soetomo General Hospital Surabaya during 2018–2023, including patient demographics, clinical manifestations, nutritional status, histopathological and anatomical characteristics of the tumor, TNM stage, metastasis, comorbidities, therapeutic modalities, serum albumin levels, and prognosis. This was a descriptive retrospective study using secondary data obtained from medical records of esophageal cancer patients at the Oncology Clinics of ENT-HN and Internal Medicine Departments, Dr. Soetomo General Hospital, from 2018 to 2023. Total sampling was applied, with 65 patients meeting the inclusion criteria out of 157 cases. Data analyzed included demographic characteristics, clinical symptoms, nutritional status, tumor type and location, TNM stage, presence of metastasis, comorbidities, therapy received, serum albumin levels, and treatment outcomes. The data were analyzed descriptively and presented as frequency distributions. The majority of patients were male and aged ≥60 years, presenting with dysphagia as the most common symptom. Most patients were diagnosed at advanced stages, with squamous cell carcinoma as the predominant histological type and the distal third of the esophagus as the most frequent tumor location. Common comorbidities included hypertension and diabetes mellitus. Many patients had hypoalbuminemia, reflecting poor nutritional status. Therapeutic modalities provided included gastrostomy, chemotherapy, radiotherapy, or their combination, although a substantial proportion received only supportive care. Mortality remained high, and curative outcomes were limited. Esophageal cancer cases at Dr. Soetomo General Hospital were predominantly diagnosed at advanced stages with poor nutritional status and multiple comorbidities, resulting in limited curative treatment options and poor prognosis. Strengthening early detection, nutritional optimization, and multidisciplinary care are crucial to improving outcomes in esophageal cancer patients.

Co-Authors Adaninggar PN Amie Vidyani Budi Yuwono Dyah Peni Puspitasari Herry Purbayu Iswan A Nusi Iswan Abbas Nusi Jualita Heidy Saputri Poernomo B Setiawan Prayitno, Jongky Hendro Puguh Setyo Nugroho Rizka Fathoni Perdana Saskia Andiani Thamrin, Husin Titong Sugihartono Ulfa Kholili Ummi Maimunah

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