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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat Biomolecular and Health Science Journal Keluwih: Jurnal Kesehatan dan Kedokteran CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL AKSONA The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Folia Medica Indonesiana
Thamrin, Husin
Division Of Gastroentero-Hepatology, Department Of Internal Medicine, Faculty Of Medicine- Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, Indonesia,
Religion Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Relationships Between Body Mass Index with Cholelithiasis Husin Thamrin; Nadieda Ayu Marthalitasari; Subur Prajitno
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 1 (2020)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v4i1.3322

Abstract

AbstractGallstones formed due to imbalance of bile components, excessive/ high level of cholesterol, nor bilirubin. Obesity was a condition where body mass index (BMI) was excess, which can cause health problems such as an increase of cholesterol, triglycerides, insulin levels, and blood pressure. There’s growing attention to cholelithiasis in Indonesia, but there wasn’t any data on the prevalence due to the limited amount of study related to cholelithiasis and BMI. This study aimed to analyze the relationship between BMI and cholelithiasis in Dr. Soetomo General Hospital. An analytical descriptive study with the case-control design was conducted, and the data were collected from medical records. The sample was 124 patients from the internal outpatient clinic Dr. Soetomo General Hospital. The data were analyzed using a t-test 2 independent sample. The ratio between female and male patients was 3:1, mean of age was 36-45 years, 45.2% had weight range from 61-70 kg, 51.2% had height range 150-159 cm, the BMI from patient with cholelithiasis specifically 45.3% on at-risk scale and 40% on obese I, the result showed p-value 0.089 (p>0.05), which means that there was no significant differences with the BMI from patients with cholelithiasis and without cholelithiasis. In conclusion, BMI could not be used as a parameter to determine the occurrence of cholelithiasis on an individual.Keywords: body mass index, cholelithiasis, gallstone
Characteristics of Laryngopharyngeal Reflux: A retrospective descriptive study Rizka Fathoni Perdana; Reyna Cesariyani Rahmadianti Rusuldi; Husin Thamrin; Rosa Falerina
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 6, No 2 (2022): Journal Qanun Medika Vol 6 No 02
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v6i2.11647

Abstract

Laryngopharyngeal reflux (LPR) is a condition of reverse flow of gastric and duodenal fluid that reaches the aerodigestive tract, causing inflammation in the upper respiratory tract. Reflux Symptoms Index (RSI) and Reflux Finding Score (RFS) have been used as instruments to determine the symptoms and signs in LPR patients. This study aims to find out the characteristics of patients with LPR. A retrospective descriptive study was performed using medical records as a source of information to obtain the characteristics of patients with LPR in ENT Outpatient Clinic Dr. Soetomo General Academic Hospital Surabaya. The study population is all patients that has been diagnosed with LPR based on RSI >13 and RFS >7 in the period 2018-2019. Our finding shows the total patients diagnosed with LPR were 58. There were 45 patients diagnosed solitarily according to the results of the RSI score, while the RFS was 34 patients. The total patients diagnosed according to both of RSI and RFS were 21 patients. In this study, 67.24% patients with LPR were female, while the male patients were 32.76%. Most patients with LPR belonged to 50 – 59 years (25.86%). The distribution of occupation shows the highest number of patients is unemployed (43.10%). The most frequent and severe complaints from LPR patients were throat clearing, sensation of something sticking in throat or lump, and excess throat mucus or postnasal drip. The laryngoscopy findings compiled on the RFS showed that the most common signs in LPR patients were subglottic edema, thick endolaryngeal mucus, and posterior commissure hypertrophy.
Response Evaluation of Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatocellular Carcinoma with Respect to Tumour Size, Number of Lesion, and Alpha-Fetoprotein (AFP) Level Adaninggar PN; Ulfa Kholili; Ummi Maimunah; Poernomo B Setiawan; Iswan A Nusi; Herry Purbayu; Titong Sugihartono; Budi Widodo; Husin Thamrin; Amie Vidyani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 17, No 1 (2016): VOLUME 17, NUMBER 1, April 2016
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.599 KB) | DOI: 10.24871/17120163-9

Abstract

Background: Transarterial chemoembolization (TACE) is widely used as a palliative treatment for unresectable hepatocellular carcinoma (HCC). TACE is also used as bridging therapy before liver transplantation to avoid tumour progression and considered for downstaging to fulfill tumour resection or liver transplantation criterias. This study aimed to evaluate response of TACE in unresectable HCC according to changing of tumour size, number of lesion, and AFP level.Method: Retrospectively, we evaluate 69 HCC patients who underwent TACE in Dr. Soetomo General Hospital in January 2012-June 2015, including their age, sex, aetiologies, and Barcelona Clinic Liver Cancer/BCLC staging. Laboratory examinations such as complete blood count (hemoglobin/Hb, leucocyte, thrombocyte), liver function test (aspartate aminotransferase/AST, alanine aminotransferase/ALT, bilirubin, albumin, international normalized ratio/INR), alpha-fetoprotein/AFP level, and abdominal CT-scan were performed before and 1 month post-TACE. Data was analysed using paired t-test.Results: 69 patients with mean age of 51.81 ± 12.8 years old, predominantly 76.8% males, the most common aetiology was hepatitis B 68.1%, 92.8% BCLC B, 64.3% with stable disease, none achieved complete response, 97.1% had tumour size 5 cm, 69.6% had single tumour, and 55.7% had AFP level 1000 ng/mL. There was a significant increase in tumour size and number of lesions in 1 month post-TACE that were approximately 1.76 cm and 2.33, respectively, and there was no significant difference between AFP level before and 1 month post TACE.Conclusion: In 1 month post TACE evaluation, there was a significant increase of tumour size and number of lesion, but there was no significant alteration in AFP level. TACE might be performed repeatedly with shorter evaluation interval than 1 month to achieve better response.
Wilson’s Disease: A Review Amie Vidyani; Fauziah Diayu Retnaningtyas; Ulfa Kholili; Titong Sugihartono; Iswan Abbas Nusi; Poernomo Boedi Setiawan; Ummi Maimunah; Budi Widodo; Husin Thamrin; Muhammad Miftahussurur; Herry Purbayu
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.36428

Abstract

Wilson’s disease is a disease that results from a genetic disorder that causes copper accumulation. Wilson’s disease has presented challenges for physicians during the last century, but it can be diagnosed and treated over time. Diagnosing Wilson’s disease is challenging for doctors because of its wide range of clinical manifestations and complexity. Studies that can help diagnose Wilson’s disease include a 24-hour copper urine examination and neurological tests, such as a CT scan or MRI, and liver function tests. There is also a scoring system to help medical personnel diagnose this disease. Correct diagnosis and adequate therapy can be provided, such as penicillamine, trientine, zinc, and, most rarely, liver transplantation. It is also necessary to monitor the side effects of treatment and its effectiveness of treatment. When receiving therapy, Wilson’s disease has a better prognosis than if it is not treated.
Exhaled Breath Analysis for COVID-19 Investigation: Clinical instruments or Scientific Toys? Isna Mahmudah; Naufali Rizkiawan; Husin Thamrin; Brian Eka Rahman; Hasan Maulahela; Yudith Annisa Ayu Rezkitha; Yoshio Yamaoka; Muhammad Miftahussurur
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 6 No. 1 (2023): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/abdimas.v6i1.2910

Abstract

The COVID-19 pandemic was crucial worldwide. Ongoing COVID-19 disease investigation methods were primarily based on molecular and serological detection. These instruments are invasive and necessarily require the use of trained personnel. Non-invasive COVID-19 investi-gation methods could help diagnose and monitor the outbreak. Because the SARS-CoV-2 virus is non-living, it lacks its metabolism. Different infectious diseases can release volatile organic compounds (VOCs), resulting in specific VOCs. All of these are metabolic products primarily produced locally in the respiratory system and systemically via blood circulation. We overview the clinical applications in the COVID-19 investigation and summarize the methodological is-sues. Numerous VOCs in the exhaled breath have the prospects to distinguish patients from healthy people and people infected with COVID-19. It is hard to define COVID-19 using VOCs from exhaled breath. Due to a lack of standardization in data collecting and processing proce-dures, their use in clinical practice is hampered. There are insufficient studies and external vali-dation to determine whether exhaled breath analysis adds value to the diagnostic and follow-up processes for COVID-19 infection. In conclusion, the use of VOCs in exhaled breath as a marker for COVID-19 infection has not been validated for clinical use.
Association of Metabolic Syndrome with Albuminuria in Diabetes Mellitus Type 2 Thamrin, Husin; Sutjahjo, Ari; Pranoto, Agung; Soelistijo, Soebagijo Adi
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (266.341 KB) | DOI: 10.20473/bhsj.v2i2.14964

Abstract

Background : Metabolic syndrome is a risk factor for cardiovascular disease as well as the occurrence of chronic kidney disease. According to the IDF, the metabolic syndrome is diagnosed when central obesity obtained with 2 or more metabolic abnormalities that include impaired glucose metabolism, increased blood pressure, hypertriglyceridemia, and low HDL-C. Several previous studies reported an  significant association found between the metabolic syndrome with albuminuria. In Indonesia, the association of metabolic syndrome with albuminuria in type 2 diabetes have not been.reported.Objectives : To investigate the association of metabolic syndrome with albuminuria in type 2 diabetes patients.Methods : This is an analytic observational study, cross-sectional design in type 2 diabetes mellitus patients and we studied 131 subjects. Criteria metabolic syndrome according to IDF consensus and albuminuria assessed using the ACR method and the classification of albuminuria was based on consensus of Perkeni 2006. As for Statistical analysis using spearman correlation and Mann-whitney test. Significance level used was 0.05.Results : Of the 131 type 2 diabetes patients with metabolic syndrome were found  normoalbuminuria proportion 65.4%, microalbuminuria 27.1% and macroalbuminuria 7.5%. Obtained a significant association between systolic blood pressure with albuminuria, p = 0.000, r = 0.325. Fasting blood sugar with albuminuria, p = 0.01, r = 0.223. But not found significant association between diastolic blood pressure with albuminuria, p = 0.153, r = 0.125, waist circumference with albuminuria, p = 0.311, r = 0.089, low HDL with albuminuria p = 0.771, r = -0.025. Hypertriglyceridemia with albuminuria, p = 0.727 and r=0,031  Conclusion : The results of this study indicate a strong association between the components of metabolic syndrome, systolic blood pressure with albuminuria, and fasting blood sugar with albuminuria. Whereas diastolic blood pressure, waist circumference, low HDL, and hypertriglyceridemia were not found significant associations.
Epidemiologic Profile of Ischemic Stroke Patients with Dyslipidemia in Dr. Soetomo General Academic Hospital Patient Prakoso, Raditya Ardra Putra; Ardhi, Mohammad Saiful; Thamrin, Husin; Setyowatie, Sita
AKSONA Vol. 5 No. 1 (2025): JANUARY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i1.64275

Abstract

Highlight: This study provides insights into the epidemiologic profile of ischemic stroke patients with dyslipidemia in Dr. Soetomo General Academic Hospital. The majority of patients had hypertension, the most common comorbidity with low HDL-C levels Most patients showed moderate stroke severity and high levels of consciousness, with a majority proportion demonstrating recovery.   ABSTRACT Introduction: Ischemic stroke is a major medical issue, especially in individuals with dyslipidemia, as it can elevate both the likelihood and severity of stroke incidents. This study is essential due to the rising prevalence of stroke and limited data regarding ischemic stroke patients with dyslipidemia in Indonesia. Understanding these traits is important for enhancing preventative and treatment strategies. Objective: This study intended to assess the epidemiologic profile of ischemic stroke patients with dyslipidemia in a tertiary hospital in Indonesia. Methods: This descriptive study assessed 116 medical records of ischemic stroke patients with dyslipidemia admitted to Dr. Soetomo General Academic Hospital in Surabaya, Indonesia, from January to June 2023. The collected data encompassed demographics, comorbidities, lipid profiles, and clinical outcomes. Dyslipidemia was defined based on the PERKENI guidelines, and stroke severity was assessed using the GCS and NIHSS scales. Results: The majority of ischemic stroke patients with dyslipidemia (77.6%) had low HDL-C levels. There were 64 males and 52 females; most of them were between the ages of 56 and 65. Hypertension was the most common comorbidity (64.7%), followed by diabetes (39.7%), heart disease (12.9%), and obesity (11.2%). Of 40 NIHSS-assessed patients, 26 had moderate, 8 mild, 2 moderate-to-severe, and 4 severe strokes. The majority of patients (70.7%) recovered. Conclusion:The majority of dyslipidemia-related ischemic stroke patients, aged 56 to 65, had low HDL-C levels. Hypertension was the main comorbidity, with many experiencing their first stroke. Most patients had high consciousness, moderate stroke severity, and showed improvements.  
A Case Report Capecitabine-Induce Grade II Hand and Foot Syndrome Nurul Damayanti; Putri Ramadhani; Khusnul Fitri Hamidah; Husin Thamrin
Keluwih: Jurnal Kesehatan dan Kedokteran Vol. 6 No. 2 (2025): Keluwih: Jurnal Kesehatan dan Kedokteran (June)
Publisher : Direktorat Penerbitan dan Publikasi Ilmiah, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/kesdok.V6i2.7305

Abstract

Abstract—Capecitabine has a common side effect of hand and foot syndrome (HFS). It is cutaneous capecitabine’s adverse effect, which generally occurs within 11 to 360 days. In this case report assesses the delayed onset of capecitabine because HFS did not occur within 11-360 days but rather took longer, specifically 720 days. A female patient of 82 years old with a history of breast cancer was diagnosed four years ago. She did not undergo radiation and surgery, only capecitabine tablets as neoadjuvant therapy since April 2021. In August 2023, the patient complained of pain, dryness, and blood in both legs. Analysis of side effects of the drug was carried out using the Naranjo Probability Scale. Therapy management during hospitalization involves stopping capecitabine and performing wound care by applying fusidic acid cream and the patient's complaints improved on the eleventh day of therapy. Capecitabine discontinuation is the most effective strategy to minimize the effect of HFS. Further research is to determine the effectiveness of emollient application as a prevention for HFS. Keywords: adverse effects, capecitabine, hand and foot syndrome Abstrak—Sindrom tangan dan kaki efek samping yang sering terjadi pada penggunaan kapesitabine. Efek samping ini merupakan efek samping pada kulit yang terjadi dalam jangka waktu 11 hingga 360 hari. Pada case report ini efek samping tidak terjadi dalam jangka waktu 11-360 hari, terjadi keterlambatan reaksi yang berlangsung pada 720 hari setelah penggunaan kapesitabin. Seorang pasien perempuan berusia 82 tahun dengan riwayat kanker payudara didiagnosis empat tahun lalu. Pasien tidak menjalani radiasi dan operasi, hanya mengonsumsi tablet kapesitabin sebagai terapi neoadjuvan sejak April 2021. Pada Agustus 2023, pasien mengeluhkan nyeri, kulit kering, dan berdarah pada kedua kakinya. Analisis efek samping obat dilakukan dengan menggunakan Skala Probabilitas Naranjo. Penatalaksanaan terapi selama rawat inap meliputi penghentian kapesitabin dan perawatan luka dengan krim asam fusidat dan keluhan pasien membaik di hari ke-11 terapi. Penghentian kapesitabin merupakan strategi yang paling efektif untuk meminimalkan efek HFS. Penelitian selanjutnya adalah untuk menentukan efektivitas pemberian emolien sebagai pencegahan HFS. Kata kunci: efek samping, kapesitabin, sindrom kaki dan tangan
Profile of Colorectal Tumor in Gastroentero-Hepatology Center, Department of Internal Medicine, Dr Soetomo Hospital, Surabaya Thamrin, Husin; Ilmiah, Khafidhotul; Tirthaningsih, Ni Wajan
Folia Medica Indonesiana Vol. 56, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Colorectal cancer has became burden in the world.The latest study shows that colorectal cancer is the third most common cancer in men and second most common cancer in women globally. There are difference characteristic of epidemiology in every countries. Moreover, there is no study that represents epidemiology of colorectal cancer in Indonesia yet, especially in East Java. The aim of this study was to describe colorectal tumor profile by age and gender in Gastroentero-Hepatology Center, Dr Soetomo Hospital. This study has received a certificate of Ethical Clearance No.273/Panke.KKE/IV/2015, a descriptive retrospective study. We collected data using medical records, and patients who have been colonoscopy examination and suspected colorectal tumor were included. There were 201 patients, divided to 100 males and 101 females. The peak of incidence was on 51-60 years old group, but on the 31-40 years old incidence of colorectal tumor was increased. The youngest patient was 17 years old. And tumors are more likely develop in distal area, especially in rectum. This study shows a different characteristic profile of colorectal tumor, where tumor is developed at young people and there is no significant difference between male and female for the incidence.
Co-Authors Adaninggar PN Agung Pranoto Amie Vidyani Ardhi, Mohammad Saiful Ari Sutjahjo, Ari Brian Eka Rahman Budi Widodo Budi Widodo Falerina, Rosa Fauziah Diayu Retnaningtyas Hasan Maulahela Herry Purbayu Ilmiah, Khafidhotul Isna Mahmudah Iswan A Nusi Iswan A Nusi Iswan Abbas Nusi Khusnul Fitri Hamidah Muhammad Miftahussurur Nadieda Ayu Marthalitasari Naufali Rizkiawan Nurul Damayanti PN, Adaninggar Poernomo B Setiawan Poernomo Boedi Setiawan Prakoso, Raditya Ardra Putra Putri Ramadhani Reyna Cesariyani Rahmadianti Rusuldi Rizka Fathoni Perdana Setiawan, Poernomo B Sita Setyowatie Soelistijo, Soebagijo Adi Subur Prajitno Tirthaningsih, Ni Wajan Titong Sugihartono Ulfa Kholili Ummi Maimunah Widodo, Budi Yoshio Yamaoka Yudith Annisa Ayu Rezkitha