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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmasi Etam Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Hayatus Sa'adah
Akademi Farmasi Samarinda
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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FORMULASI ORALLY DISINTEGRATING TABLET (ODT) ASETOSAL DENGAN VARIASI KONSENTRASI KOMBINASI AVICE Hayatus Sa'adah; Yulistia Budianti S.; Akhmad Andy Sandra
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 1 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.066 KB) | DOI: 10.36387/jiis.v4i1.216

Abstract

Acetylsalicylic acid or better known as acetosal or aspirin is a drug that has efficacy as an antiplatelet which is widely used as a drug to prevent and treat stroke. Currently acetosal is often found in many preparations, one of which is in conventional tablet preparations. Stroke sufferers really need a drug in tablet dosage form that is easy to consume, has a relatively fast duration of drug action, and with more practical drug administration. Therefore, an acetosal preparation is made in the form of Orally Disintegrating Tablet (ODT) which has several advantages, including being more practical to use because it can be consumed without using water and can be used by patients who are difficult to swallow conventional tablets. Research conducted on acetosal ODT formulation with variations in the combination concentration of Avicel PH 102 and mannitol as filler material. In this study, the physical properties of ODT acetosal were tested by varying the combination concentration of Avicel PH 102 and mannitol as a filler with a ratio of F1 = 0: 1, F2 = 0.25: 0.75, F3 = 0.5: 0.5 , F4 = 0.75: 0.25, and F5 = 1: 0. The ODT evaluation was carried out in the form of examining the weight uniformity test, hardness test, friability test, and tablet disintegrating time test. The results of the study obtained the best formula is F4 with a comparison of Avicel PH 102 and manitol 0.75: 0.25 that meets the requirements of physical properties of ODT with the average value of tablet weight uniformity test 382.5 mg ± 0.007, tablet 2 hardness test, 52 kg / cm2 ± 0.396, tablet friability test 0.53% ± 0.153, and tablet disintegrating time test 21 seconds ± 3.605.
Formulation and Evaluation Lotion of Tengkawang Seed Fat (Shorea mecistopteryx Ridley) and Cocoa Fat (Theobroma cacao L.) as a Base Maria Elvina Tresia Butar-Butar; Yulia Sukawaty; Hayatus Sa'adah
Jurnal Farmasi Etam (JFE) Vol 1 No 1 (2021): Juni
Publisher : Unit Penelitian dan Pengabdian Kepada Masyarakat (UPPM) STIKES Dirgahayu Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.325 KB) | DOI: 10.52841/jfe.v1i1.188

Abstract

ABSTRAK Lemak biji tengkawang (Shorea mecistopteryx Ridley) merupakan salah satu tumbuhan khas Kalimantan yang memiliki karakteristik fisik menyerupai lemak kakao. Kandungan lemak nabati yang tinggi pada lemak biji tengkawang, seperti asam oleat sebesar 55,95%, asam palmitat 14,02%, miristat 0,05%, dan stearat 0,05% mendorong peneliti untuk melakukan penelitian dengan memanfaatkan lemak biji tengkawang sebagai basis dalam pembuatan sediaan kosmetika, seperti losion. Penelitian ini dilakukan dengan mengkombinasi lemak biji tengkawang dan lemak kakao sebagai basis losion. Kombinasi ini bertujuan untuk mengetahui karakteristik fisik losion yang dihasilkan dari perbedaan kosentrasi. Karakteristik fisik losion diketahui melalui beberapa evaluasi, yaitu organoleptis, homogenitas, viskositas, pH, daya lekat, penyusutan bobot, dan stabilitas secara mekanik. Berdasarkan evaluasi yang dilakukan diperoleh data yang menunjukkan adanya pengaruh yang disebabkan oleh perbedaan kosentrasi basis terhadap karakteristik fisik losion. Perbedaan karakteristik fisik yang mencolok terutama terlihat pada nilai viskositas yang menunjukkan formula I 1485,55 cp, formula II 3408,88 cp, formula III 2017,77 cp, dan formula IV 3314,44 cp. Viskositas meningkat seiring lama waktu penyimpanan dan ini berbanding lurus dengan kemampuan daya lekat losion. ABSTRACT Tengkawang seed fat (Shorea mecistopteryx Ridley) is one of the typical plants of Kalimantan that has physical characteristics resembling cocoa fat. The high content of vegetable fats in tengkawang seed fats, such as oleic acid by 55.95%, palmitic acid 14.02%, miristat 0.05%, and stearate 0.05% encouraged researchers to conduct research by utilizing tengkawang seed fat as the basis in the manufacture of cosmetic preparations, such as lotions. This research was conducted by combining tengkawang seed fat and cocoa fat as the basis of lotion. This combination aims to determine the physical characteristics of lotions resulting from differences in concentration. The physical characteristics of lotions are known through several evaluations, namely organoleptis, homogeneity, viscosity, pH, adhesion, weight shrinkage, and mechanical stability. Based on the evaluation conducted obtained data that shows the influence caused by differences in the concentration of the base to the physical characteristics of lotions. Striking differences in physical characteristics are especially noticeable in viscosity values indicating formulation I 1485.55 cp, formulation II 3408.88 cp, formulation III 2017.77 cp, and formulation IV 3314.44 cp. Viscosity increases over a long period of time and this is directly proportional to the lotion's adhesion capability.
OPTIMASI FORMULA EKSTRAK JAHE MERAH (Zingiber officinale) DENGAN METODE KEMPA LANGSUNG MENGGUNAKAN ANALISIS SIMPLEX LATTICE DESIGN Hayatus Sa'adah
Jurnal Ilmiah Manuntung Vol 1 No 1 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i1.11

Abstract

Processing of medicinal plants into the appropriate dosage form can ensure security during use. It is a motivation in making acceptable dosage form which is easy and convenient to use, especially the manufacture of ethanol extract red ginger tablets using a combination of starch 1500 and amprotab.The study begins with the manufacture of dry extract of red ginger. Optimization of making tablets using a combination of starch 1500 and disintegrator with simplex lattice design using three formulas is done by direct compaction method. Further testing on the tablet hardness, friability and disintegration time.The results showed starch 1500 has a greater influence increase hardness and disintegration time of tablets, as well as lowering the fragility of the tablet. While the interaction of starch 1500 and disintegrator has no effect on the physical tablet. The optimum proportion of the combination of starch 1500 and disintegrator meet the physical requirements of tablets with a ratio of 4: 6 with 7.99 kg hardness, the friability of 0.32% and disintegration time of 2.42 minutes
PERBANDINGAN PELARUT ETANOL DAN AIR PADA PEMBUATAN EKSTRAK UMBI BAWANG TIWAI (Eleutherine americana Merr) MENGGUNAKAN METODE MASERASI Hayatus Sa'adah; Henny Nurhasnawati
Jurnal Ilmiah Manuntung Vol 1 No 2 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i2.27

Abstract

Bawang tiwai (Eleutherine americana Merr) is one kind of medicinal plant. To obtain an active substances with good physical and chemical properties, it is needs to do optimization of making extracts, one with solvent optimization. Type of solvent will determine the types of extracted substances in accordance with the polarity. On this research, extraction of bawang tiwai bulbs simplicia by maceration method using ethanol and water as solvent. This research is an experimental research with varying ethanol and water in a three comparison solvent that is water, ethanol, and mixture of water-etanol, then the yields is calculated. Furthermore, the data were analyzed statistically using ANOVA program to determine significant differences in the three yields. In each extract was conducted phytochemical screening to determine the content of secondary metabolites. The results showed significant differences in the yield of bawang tiwai extract with three treatments and two repetitions. The results of average yields using water as solvent is 8.75%, ethanol 5.3%; and water-etanol 8.31%
UJI MUTU FISIK GRANUL EKSTRAK ETANOL DAUN KEMANGI (Ocimum americanum L.) DENGAN VARIASI KONSENTRASI EXPLOTAB® Yulistia Budianti Soemarie; Hayatus Sa'adah; Nurul Fatimah; Tri Marga Ningsih
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v3i1.92

Abstract

Bad breath is usually caused by bacteria and food debris left in the mouth. Development of preparations using herbal ingredients, to overcome the problem of bad breath one of them is with utilization basil leaves (Ocimum americanum L.) which have anti bacterial activity. The method of wet granulation is a single method for use in granulation of large doses of active substances because if using direct induced method will require again the addition of a large number of fillers to make it easier forging, but cause the tablet to be not feasible as it will resulting in an increase in tablet size. The type of research conducted is an experimental study. Object the study was basil leaf extract formulated. This formulation was prepared by wet granulation method with variation Explotab® ss crusher ie 2%, 4%, 6% and 8%. Performed wet granulation on each formulation. Granul evaluated the flow time, mass density test, silent angle and fixed assay test. Based on research result the physical quality of ethanol extract granule of basil leaves (Ocimum americanum L.) with explotab® concentration variation it can be concluded that all the formula fulfill the good quality of granule characteristic, because it meets the requirements of parameters of time flow, rest angle, compressibility and density mass
Co-Authors Akhmad Andy Sandra Henny Nurhasnawati Maria Elvina Tresia Butar-Butar Nurul Fatimah Tri Marga Ningsih Yulia Sukawaty Yulistia Budianti S. Yulistia Budianti Soemarie