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Mahfuzun Bone
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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Skrining Fitokimia dan Profil Kromatografi Lapis Tipis (KLT) Tumbuhan Antimalaria Asal Indonesia: Phytochemical Screening and Thin Layer Chromatography Profile of Indonesia Plants Muhammad Arifuddin; Mahfuzun Bone
Jurnal Sains dan Kesehatan Vol. 2 No. 3 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i3.113

Abstract

Phytochemical screening tests have been carried out to detect secondary metabolites in several plants, namely Brotowali stem (Tinospora crispa), Jambu Biji leaves (Psidium guajava), Manggis rind (Garcinia mangostana), Pare fruit (Momordica charantia), Pepaya leaves (Carica papaya), Pulai sari stem bark (Alstonia scholaris), Sirsak leaves (Annona muricata). The test results obtained the state that each sample of the plant contains secondary metabolites which have the potential as antimalarial compounds.
Karakterisasi Senyawa Bioaktif Antimikroba Ekstrak Umbi Bawang Tiwai (Eleutherine Bulbosa (MILL.) URB.) Mahfuzun Bone; Yusnita Rifai; Gemini Alam
Jurnal Sains dan Kesehatan Vol. 2 No. 1 (2019): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i1.119

Abstract

bulbosa adalah tanaman khas suku Kalimantan yang telah digunakan secara turun-temurun sebagai antibakteri. Penelitian ini bertujuan untuk menentukan karakterisasi senyawa aktif antimikroba E. bulbosa. Tahapan penelitian diawali dengan ekstraksi E.bulbosa dengan pelarut metanol dan partisi cair-cair menggunakan pelarut n-heksan, etil asetat, n-butanol. Uji Skrining antimikroba ekstrak methanol, n-heksan, etil asetat, dan n-butanol dengan konsentrasi 1 mg/mL. Ekstrak n-heksan difraksinasi dengan kromatografi cair vakum dan direfraksinasi kembali menggunakan sepacore. Fraksi aktif diisolasi dengan kromatografi lapis tipis preparatif dan diperoleh isolat aktif E. bulbosa. Hasil Identifikasi berdasarkan kromatogram menunjukkan isolat aktif E.bulbosa adalah golongan naphthalene. interpretasi data spektroskopi FTIR isolat aktif E.bulbosa menunjukkan adanya gugus OH hidroksil, CH alifatik, dan C=O. Hasil Interpretasi data 1H NMR isolat aktif E. bulbosa menunjukkan Data 1H NMR memperlihatkan adanya spektrum dari atom H-6 dengan nilai ? 6,92 ppm Mult. doblet dan J 10,5 Hz, spektrum dari atom H-8 dengan nilai ? 7,75 ppm, Mult. doblet dan J 10,5 Hz, spektrum dari atom H-9 dengan nilai ? 6,29 ppm, dan spektrum H-11 dengan nilai ? 3,21 ppm. Nilai Konsentrasi Hambat Minimum (KHM) isolat aktif E.bulbosa terhadap bakteri uji V. cholera, B. subtilis, S. mutans, S. aureus 0,0125% dan bakteri E. coli 0,025%. Disimpulkan bahwa isolat aktif E. bulbsoa adalah golongan senyawa naftalen dan memiliki aktivitas antimikroba.
ANTIBACTERIA ACTIVITY ETHANOL EXTRACT OF ACHRAS ZAPOTA L. FRUIT AND LAGENARIA SICERARIA (MOLINA) STANDL. AGAINST SALMONELLA TYPHI Saldi Hapiwaty; Yuri Pratiwi Utami; Imrawati; Mahfuzun Bone; Nurjannah Bachri; Rahmah Mustarin; Ainun Jariah; Zahira Amody; Benedikta Winne Angela
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3103

Abstract

The Synergistic of antibacterial is an interaction of two antibacterial agents that produces a greater inhibitory effect on bacteria, compared to the individual antibacterial effects of the two agents. The purpose of this study was to determine the synergistic effect of anti-bacterial extract of sapodilla fruit (Achras zapota L.) and water gourd (Lagenaria siceraria (Molina) Standl.) extract against Salmonella typhi bacteria. Extraction of sapodilla fruit and water gourd fruit was carried out by maceration method using 96% ethanol (1:10). Determination of the value of the minimum inhibitory concentration (MIC) of anti-bacterial sapodilla manila fruit and water gourd fruit was carried out by the checkerboard assay method using a 96 wells microplate by calculating the Fractional Inhibition Concentration Index (FICI) value. The results showed that the single MIC value of sapodilla manila fruit and water gourd fruit respectively are 50 mg/mL and 100 mg/mL. The interaction between the two is expressed as a Fractional Inhibitory Concentration Index (FICI) with a value of 1.5. The FICI values ​​indicate different antibacterial effects of the combination of sapodilla fruit and water gourd fruit against Salmonella typhi. Keywords: Synergistic, Salmonella typhi, Achras zapota L., Lagenaria siceraria (Molina) Standl., FICI
Co-Authors Ainun Jariah Benedikta Winne Angela Gemini Alam Imrawati Muhammad Arifuddin Nurjannah Bachri Rahmah Mustarin Saldi Hapiwaty Yuri Pratiwi Utami Yusnita Rifai Zahira Amody