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Imrawati
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Physics

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OPTIMIZATION OF ANTIOXIDANT ACTIVITY OF 96% ETHANOL EXTRACT OF Chromolaena odorata L. ABTS RADICAL PROPHYLACTIC Usman, Yuri Pratiwi Utami; Rahmah Mustarin; Imrawati; Nurzadrina Wahyuddin; Suhaera; Besse Yuliana
JURNAL KATALISATOR Vol. 9 No. 1 (2024): Jurnal Katalisator Volume 9 No.1, April 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i1.2817

Abstract

Choromolaena odorata L. is one of the plants used as an antioxidant. This research aims to determine the optimization of the antioxidant activity of 96% ethanol extract of C. odorata L. leaves using the ABTS method, a variety of drying techniques. Previous research has tested antioxidant activity using one drying technique, whereas this research uses a variety of drying techniques because the sample drying technique will affect its activity. Simplicia is obtained from various drying techniques. Then the simplicia was organoleptically tested and its water content was measured using the distillation method. The ethanol extract of Tacklean leaves was carried out using the maceration method using 96% ethanol solvent, then phytochemical screening was carried out using the TLC method and the antioxidant activity test of the ethanol extract of C. odorata L leaves was carried out using the ABTS method. The formation of the ABTS radical cation [2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) forms the basis of one of the spectrophotometric methods that has been applied to the measurement of total antioxidant activity of plants. The research results from the three drying techniques (50°C oven, direct sun drying, and air drying) showed organoleptic results in successive colors (brown, chocolate and dark green), while for shape and odor, namely dry leaves and a distinctive odor. The water content of simplicia ranges from 7.52-9.31%, soaked extract 8.4-10.3% and IC50 23.287-29.064 µg/mL and quarcetin as a comparison with IC50 2.292 µg/mL. Phytochemical screening results contain alkaloids, flavonoids, steroids and tannins. Oven drying at 50°C produced the greatest antioxidant activity with an IC50 value of 23.287 µg/mL which indicates very strong antioxidant power, although the antioxidant activity with a variety of drying techniques was all in the very strong category because it was <50 µg/mL.
ANTIBACTERIA ACTIVITY ETHANOL EXTRACT OF ACHRAS ZAPOTA L. FRUIT AND LAGENARIA SICERARIA (MOLINA) STANDL. AGAINST SALMONELLA TYPHI Saldi Hapiwaty; Yuri Pratiwi Utami; Imrawati; Mahfuzun Bone; Nurjannah Bachri; Rahmah Mustarin; Ainun Jariah; Zahira Amody; Benedikta Winne Angela
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3103

Abstract

The Synergistic of antibacterial is an interaction of two antibacterial agents that produces a greater inhibitory effect on bacteria, compared to the individual antibacterial effects of the two agents. The purpose of this study was to determine the synergistic effect of anti-bacterial extract of sapodilla fruit (Achras zapota L.) and water gourd (Lagenaria siceraria (Molina) Standl.) extract against Salmonella typhi bacteria. Extraction of sapodilla fruit and water gourd fruit was carried out by maceration method using 96% ethanol (1:10). Determination of the value of the minimum inhibitory concentration (MIC) of anti-bacterial sapodilla manila fruit and water gourd fruit was carried out by the checkerboard assay method using a 96 wells microplate by calculating the Fractional Inhibition Concentration Index (FICI) value. The results showed that the single MIC value of sapodilla manila fruit and water gourd fruit respectively are 50 mg/mL and 100 mg/mL. The interaction between the two is expressed as a Fractional Inhibitory Concentration Index (FICI) with a value of 1.5. The FICI values ​​indicate different antibacterial effects of the combination of sapodilla fruit and water gourd fruit against Salmonella typhi. Keywords: Synergistic, Salmonella typhi, Achras zapota L., Lagenaria siceraria (Molina) Standl., FICI
Antibacterial Potential of Muntingia calabura L. Ethanol Extract Against MDR Escherichia coli Utami, Yuri Pratiwi; Latu, Saparuddin; Mustarin, Rahmah; Imrawati; Yudistira, Aditya; Rahmatia
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.7765

Abstract

Kersen leaves (Muntingia calabura L.) have long been utilized as a traditional medicinal plant used for headaches, antiseptics, antioxidants, antimicrobials, anti-inflammatories, anti-diabetics, and anti-tumors. This study aims to determine the antibacterial activity and the concentration at which kersen leaf extract can inhibit the growth of Multi Drug Resistant (MDR) Escherichia coli bacteria. The type of research conducted is a laboratory-scale experimental study. The kersen leaves were extracted using the maceration method with a 70% ethanol solvent. The antibacterial activity was tested using the agar diffusion method with sensitive and MDR Escherichia coli bacteria at varying concentrations of 1.25%, 2.5%, 5%, and 10%, conducted in three replicates and incubated for 24 hours. Subsequently, the inhibition zones were measured and the data were statistically processed. Based on the research results, at a concentration of 1.25%, an inhibition zone of 7.86 mm was obtained, at 2.5% concentration 9.65 mm, at 5% and 10% concentrations 11.93 mm and 13.98 mm on sensitive Escherichia coli bacteria, while on MDR Escherichia coli bacteria at a concentration of 1.25%, an inhibition zone of 6.51 mm was obtained, at 2.5% concentration 6.61 mm, at 5% and 10% concentrations 6.68 mm and 6.98 mm. These findings suggest that kersen leaf extract possesses moderate antibacterial activity against both sensitive and MDR E. coli, particularly at higher concentrations.
Co-Authors Aditya Yudistira Ainun Jariah Benedikta Winne Angela Besse Yuliana Mahfuzun Bone Mustarin, Rahmah Nurjannah Bachri Nurzadrina Wahyuddin Rahmah Mustarin Rahmatia Saldi Hapiwaty Saparuddin Latu Suhaera Yuri Pratiwi Utami Zahira Amody