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PEMBUATAN EKSTRAK SEREH (Cymbopogon nardus L.) DALAM SEDIAAN LOTIO Nurjannah Bachri; Nursalma Nursalma; Natalia Nora
As-Syifaa Jurnal Farmasi Vol 7, No 2 (2015): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

This experiment research have been conducted in the pharmaceutical technology laboratory, it aims of making the pharmaceutical in the form of latio of citronella extracts. This research used citronella as samples that are created macerationally and produced a thick extract. The making of lotio used smelting method, namely oil phase smelting and water phase smelting. It was done by observation in organoleptic to see the stability of lotio. Based on the observations result obtained that extracts of (Cymbopogon nardus L.) can be formulated in the latio and physically stable.

UJI EFEKTIVITAS GEL EKSTRAK ETANOL DAUN BINAHONG (Anredera cordifolia) SEBAGAI PENYEMBUHAN LUKA INSISI PADA TIKUS WISTAR JANTAN Nurhikma Awaluddin; Nurfiddin Farid; Nurjannah Bachri
Jurnal Kesehatan Vol 13 No 2 (2020): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v13i2.16435

The effectiveness test of Binahong Leaf (Anredera cordifolia) ethanol extract gel as an incision wound healing in male Wistar rats by Nurhikma Awaluddin and Nurfiddin Farid. Injuries are structural or physiological integument disorders that require a normal or abnormal tissue repair response. An incisor wound is a wound caused by a tool that has a sharp tip and hits the skin layer. The purpose of this study was to determine the effectiveness of binahong leaf ethanol extract gel on incision wound diameter and wound healing time in male Wistar rats. The method used is experimental laboratory. The incision wound was observed for 14 days. Observations consisted of changes in wound length and duration of healing. The incision wound is characterized by tearing of the epidermal tissue 2 cm long. Binahong leaf extract gel preparation test was given to the incision wound of male Wistar rats by observing the formation of maturation, the time of wound closure. For administration of extracts with a concentration of 2% for tenth days at a concentration of 10%, the wound closure occurred on the ninth day and at a concentration of 15% occurred on the eighth day. Observation of wound healing is characterized by the occurrence of complete closure of the wound on the skin, which begins with inflammation which is then followed by a process of proliferation and maturation or remodeling. The treatment of positive control using bioplastone preparation experienced faster wound closure compared to the other four formulas. The results of the ANOVA statistical analysis using SPSS, the relationship between formula and speed of closed wounds are 100%, where Fcount> Ftable at the 5% and 1% confidence levels, this means that there is a difference in wound healing time of 100% which is very different / very significant from the use of each. each formula. Binahong leaf ethanol extract gel formula is effective in healing cuts in male Wistar rats with healing time less than 14 days.ABSTRAKUji efektivitas gel ekstrak etanol Daun Binahong (Anredera cordifolia) sebagai penyembuhan luka insisi pada tikus wistar jantan oleh Nurhikma Awaluddin dan Nurfiddin Farid. Luka adalah gangguan pada structural atau fisiologi integument yang membutuhkan respons perbaikan jaringan yang normal atau tidak normal. Luka insisi merupakan luka yang disebabkan oleh alat yang berujung tajam dan mengenai lapisan kulit. Tujuan penelitian ini adalah Untuk melihat efektivitas gel ekstrak etanol daun binahong pada diameter luka insisi dan lama penyembuhan luka pada hewan uji tikus wistar jantan. Metode yang digunakan adalah eksperimental laboratorium. Pengamatan luka insisi dilakukan selama 14 hari. Pengamatan terdiri dari perubahan panjang luka dan lama penyembuhan. Luka insisi ditandai dengan merobek jaringan epidermis sepanjang 2 cm. Uji sediaan gel ekstrak daun binahong diberikan pada luka insisi tikus wistar jantan dengan melihat pembentukan maturasi, waktu penutupan luka. untuk pemberian ekstrak dengan konsentrasi 2% selama sepuluh hari, pada pemberian formula dengan konsentrasi 10% terjadi penutupan luka pada hari kesembilan dan pada konsentrasi 15% terjadi pada hari kedelapan. Pengamatan penyembuhan luka ditandai dengan terjadinya penutupan luka secara menyeluruh pada bagian kulit yang berawal adanya inflamasi kemudian disusul dengan proses proliferasi dan maturasi atau remodeling. Perlakuan pada kontrol positif yang menggunakan sediaan bioplasenton, mengalami penutupan luka yang cepat dibandingkan dengan keempat formula yang lain. Hasil analisis statistik Anova secara SPSS hubungan antara formula dan kecepatan luka tertutup 100%, di mana Fhitung > Ftabel pada taraf kepercayaan 5% dan 1%, ini berarti terdapat perbedaan waktu penyembuhan luka 100% yang sangat berbeda nyata/sangat signifikan dari penggunaan masing-masing formula. Formula gel ekstrak etanol daun Binahong memiliki efektivitas dalam menyembuhkan luka sayat pada tikus wistar jantan dengan lama penyembuhan kurang dari 14 hari.

UJI EFEKTIVITAS DAN STABILITAS HAIR TONIC EKSTRAK BAWANG MERAH (Allium cepa L.) SEBAGAI PERANGSANG PERTUMBUHAN RAMBUT Kartika Sari; Laurensia, Vivi; Bachri, Nurjannah; Mukhsin, Achmad; Indrawati, Teti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1697

External skin protection is one of the functions of hair, hair loss and even baldness are common problems. This condition is caused by two factors, namely genetics and the surrounding environment. Shallots (Allium cepa L.) are tubers that are used as a spice and medicine. The flavonoid and phenol content as antioxidants can rejuvenate and repair damaged hair cells, quercetin and kaempferol increase hair growth and prevent hair loss. This research aims to obtain a hair tonic preparation that has activity as a hair fertilizer and to obtain a hair tonic preparation that has good stability, is safe and efficacious. This research used experimental methods, effectiveness testing with Tanaka and accelerated stability testing. The effectiveness test results of healthy control, negative control, positive control, F2, F3 and F4 on the 21st day showed values respectively 12.8, 12.55, 17. .2, 16.5, 14.45 and 12.2 and stability test pH 5.73-6.82, density 0,990-1,031, brown color, liquid form, aromatic smell. The results showed that the preparation with F2 had the same results as the positive control and had a stable preparation in stability testing for 28 weeks.

Pengembangan Formulasi Dan Evaluasi Mutu Sediaan Hair Tonic Ekstrak Bawang Merah (Allium Cepa L.): Formulation Of Development And Quality Evaluation Of Red Onion (Allium Cepa L.) Extract Hair Tonic Sari, Kartika; Bachri, Nurjannah; Mukhsin, Akhmad; Laurensia, Vivi; Indrawati, Teti
Binawan Student Journal Vol. 5 No. 3 (2023)
Publisher : Direktorat Penelitian, Pengabdian Masyarakat, Dan Kerjasama Universitas Binawan (DPPMK Universitas Binawan)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54771/bsj.v5i3.1092

Bawang merah (Allium cepa L.) sebagai bumbu dapur dan obat tradisional; penyembuhan luka dan penyubur rambut. Sediaan penyubur rambut digunakan untuk menstimulasi pertumbuhan rambut. Penelitian ini bertujuan memperoleh ekstrak bawang merah bermutu baik, sediaan penyubur rambut ekstrak bawang merah 2%, 4% dan 6% memenuhi karakteristik sediaan hair tonic yang baik. Ekatraksi bawang merah dengan metode maserasi. Pembuatan hair tonic dengan metode pencampuran. Rendemen ekstrak bawang merah sebesar 30%, berbau khas aromatik, berwarna coklat, bebentuk kental, kadar sari larut air 57,22 ± 0,091, kadar sari larut etanol 40,7 ± 0,966, kadar abu 0,684 ± 0,199, kadar air 0,616 ± 0,210, susut pengeringan 0,79 ± 0,179, sisa etanol 0,06 ± 0,005, kandungan kimia; alkaloid, flavonoid, tannin, saponin, fenol. Sediaan hair tonic memenuhi karakteristik sediaan yang baik, berbetuk cair, F0 dan F1 tidak berwarna dan tidak berbau sementara untuk F2, F3 dan F4 berbau khas aromatik, berwarna coklat, viskositas 1,47-1,90 dan pH 5,87-6,10.

THE FORMULATION OF CREAM PREPARATIONS BLUSH ON OF ETANOL EXTRACT FROM MIANA PURPLE LEAVES (Coleus scutellarioides L.) AS BLUSHER Suryanita; Fitrahmia S, Nur; Auliah, Nielma; Bachri, Nurjannah
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Anthocyanin is a chemical compound found in purple miana leaves and plays an important role in providing color. Purple miana leaf extract can be used as a natural coloring in blush on cream preparations. The aim of this research is to determine whether purple miana leaf extract (Coleus scutellarioides L) can be formulated in the form of a blush cream dosage form that is physically and chemically stable. The research method used was experimental research by making blush on preparation formulations with concentrations of 7.5%, 10% and 12.5% and evaluating the preparations using physicochemical, irritation tests and hedonic tests. The research results showed that blush on formulations with concentrations of 7.5%, 10% and 12.5% were physically and chemically stable and in the hedonic/preference test the most preferred formulation was the formulation with a concentration of 12.5%. The conclusion of this research is that the ethanol extract of purple miana leaves (Coleus Scutellarioides L) can be formulated in the form of a blush cream dosage form that is physically and chemically stable.

Penetapan Sifat Fisikokimia Ekstrak Etanol Daun Mimba (Azadiractha indica A. Juss) : Penelitian Eksperimen Berskala Laboratorium Pratiwi Utami, Yuri; Imrawati, Imrawati; Jariah, Ainun; Mustarin, Rahmah; Bone, Mahfuzun; Bachri, Nurjannah
Health Information : Jurnal Penelitian Vol 16 No 3 (2024): September-Desember
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v16i3.1298

Daun mimba (Azadirachta indica A. Juss) banyak digunakan sebagai obat tradisional yaitu untuk mengobati malaria, kencing manis, diare, penurun panas, dan antitukak lambung. Aktivitas suatu ekstrak dapat dipengaruhi oleh senyawa aktif yang terkandung di dalamnya yang bergantung pada sifat fisikokimia dari ekstrak. Penelitian ini bertujuan untuk menentukan sifat fisikokimia ekstrak etanol daun mimba (A. indica A. Juss.). Penelitian bersifat experimental berskala laboratorium yang dimulai dengan sampel diproses hingga menjadi simplisia; kemudian, simplisia diekstraksi melalui metode maserasi dengan pelarut etanol 70%. Penetapan sifat fisikokimia meliputi beberapa parameter yaitu rendemen, organoleptik, kadar senyawa terlarut, penetapan kadar senyawa terlarut, skrining fitokimia, dan penetapan kadar flavonoid total. Hasil penelitian menunjukkan bahwa ekstrak etanol menghasilkan sifat fisikokimia yaitu rendemen ekstrak 19,438 %, organoleptik ekstrak (bentuk (kental); warna (hijau kehitaman); bau (khas); dan rasa (pahit)), penetapan kadar senyawa terlarut (senyawa terlarut air (62.5%); senyawa terlarut pada etanol (71.3%)), skrining fitokimia mengandung (alkaloid, flavonoid, saponin, steroid dan tannin), dan kadar flavonoid total ekstrak yaitu 1.829%. Dapat disimpulkan bahwa ekstrak etanol daun mimba (A. indica A. Juss.) dapat ditetapkan sifatnya secara fisikokimia dengan beberapa parameter yang telah diuji untuk mengetahui karakteristiknya sehingga disarankan ekstrak ini dapat dikembangkan dalam bentuk sediaan obat bahan alam.

UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL TUNAS REBUNG (Bambusa SP) PADA KAKI TIKUS WISTAR JANTAN YANG DIINDUKSI KARAGENAN Muhammad Asri SR; Winarni; Nielma Auliah; Nurjannah Bachri
Journal of Pharmaceutical Science and Herbal Technology Vol. 8 No. 2 (2023): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35892/jpsht.v1i1.1455

Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol tunas rubung (Bambusa SP) memiliki aktivitas sebagai antiinflamasi pada tikus Jantan galur wistar dan berapa konsentrasi yang paling efektif dari ekstrak etanol tunas rebung (Bambusa SP) yang memberikan aktivitas antiinflamasi yang dilihat dari dari parameter penurunan edema pada kaki tikus. Metode penelitian secara eksperimental dengan cara tikus putih Jantan galur wistar sebanyak 15 ekor diinduksi dengan karagenan yang dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 3 ekor. Kelompok control negatif diberikan Na-CMC dan control positif diberikan natrium diklofenak. Kelompok I diberikan ekstrak dengan konsentrasi 2%, kelompok II diberikan ekstrak dengan konsentrasi 4% dan untuk kelompok III diberikan ekstrak dengan konsentrasi 6%. Hasil penelitian menunjukkan bahwa : 1. Efek antiinflamasi dari ekstrak tunas rebung sangat kuat 2. Pemberian ekstrak etanol tunas rebung (Bambusa SP) berpengaruh terhadap penurunan edema pada kaki tikus Jantan galur wistar 2. Ada perbedaan pengaruh pemberiaan dosis terhadap penurunan edema pada kaki tikus Jantan galur wistar.

Uji Daya Hambat Formula Gel Ekstrak Etanol Daun Murbei (Morus alba L.) Sebagai Anti Acne Terhadap Bakteri Propionibacterium acne.: Inhibition Test of Ethanol Extract Gel of Mulberry (Morus alba L.) Leaves as an Anti Acne on Propionibacterium acne Bacteria Aliah, Ahmad Irsyad; Wahyuni, Wahyuni; Bachri, Nurjannah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

A research on the inhibition of formula gel test ethanol extract of leaves of mulberry (Morus alba L.) as an anti-acne against bacteria Propionibacterium acne. This study uses a gel formulation made using mulberry leaf extract (Morus alba L.), which aims to determine the inhibition of antibacterial gel mulberry leaf extract (Morus alba L.) against the bacteria Propionibacterium acne. Gel made three dosage concentrations of 2%, 4% and 6%. Testing inhibition of antibacterial gel agar diffusion method. Test Antibacterial inhibition obtained by looking at the clear zone in the medium and measured using calipers. The results showed that the inhibition of antibacterial gel formulation with a concentration of 2%, 4% and 6% showing that inhibiting bacterial activity.

Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus). Nurjannah Bachri; Nielma Auliah; Sri Wahyuningsih; Husna Dewi
Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Vol. 3 No. 1 (2023): Proceeding of The International Conference of Inovation, Science, Technology, E
Publisher : Program Studi DIII Rekam Medis dan Informasi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/icistech.v3i1.61

Red Ginger is a type of rhizome that is widely used as an ingredient in traditional medicine in Indonesia. The efficacy of red ginger has been widely studied as an effective anti-inflammatory. One of the main components of red ginger is the gingerol class of compounds. This study aims to determine the anti-inflammatory effect that is applied to the red ginger extract gel (Zingiber officinale var. Ruburum) gel preparation with the HPMC gel-forming ingredient. The gel preparation was then tested for stability up to day 7 and evaluated for its anti-inflammatory power against white rats (Rattus norvegicus). The method used was the artificial inflammation ordering method, where the test was carried out by injection of carrageenan as a mediator for inflammation of the thighs of white rats, then topically giving Red Ginger extract gel with a concentration of 1%, 3% and 5%, HPMC as a negative control and diclofenac sodium as a Positive control. Measurements were carried out every 8 hours every day after being induced by carrageenan to use a caliper. The results showed that the reduction in inflammation to reduce the diameter of 1% after induction was 1.76 cm and decreased to 1.22 cm, the concentration of 3% after induction was 1.68 cm and decreased to 1.33 cm, the concentration of 5% after induction was 1 , 79 cm and decreased to 1.35 cm. Data were statistically analyzed using ANOVA showing that the negative HPMC controls did not show any anti-inflammatory effects. It can show that 1%, 3% and 5% Red Ginger ethanol extract gel has anti-inflammatory effects and the greatest effect is that the 5% concentration has an anti-inflammatory effect.

Formulation And Testing The Effectiveness Of Gel Extract Of Red Ginger (Zingiber officinale Var. Rubrum) As Antiinflamatory In White Male Rats (Rattus norvegicus). Nurjannah Bachri; Nielma Auliah; Sri Wahyuningsih; Husna Dewi
Proceeding International Conference Of Innovation Science, Technology, Education, Children And Health Vol. 3 No. 1 (2023): Proceeding of The International Conference of Inovation, Science, Technology, E
Publisher : Program Studi DIII Rekam Medis dan Informasi Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/icistech.v3i1.61

Red Ginger is a type of rhizome that is widely used as an ingredient in traditional medicine in Indonesia. The efficacy of red ginger has been widely studied as an effective anti-inflammatory. One of the main components of red ginger is the gingerol class of compounds. This study aims to determine the anti-inflammatory effect that is applied to the red ginger extract gel (Zingiber officinale var. Ruburum) gel preparation with the HPMC gel-forming ingredient. The gel preparation was then tested for stability up to day 7 and evaluated for its anti-inflammatory power against white rats (Rattus norvegicus). The method used was the artificial inflammation ordering method, where the test was carried out by injection of carrageenan as a mediator for inflammation of the thighs of white rats, then topically giving Red Ginger extract gel with a concentration of 1%, 3% and 5%, HPMC as a negative control and diclofenac sodium as a Positive control. Measurements were carried out every 8 hours every day after being induced by carrageenan to use a caliper. The results showed that the reduction in inflammation to reduce the diameter of 1% after induction was 1.76 cm and decreased to 1.22 cm, the concentration of 3% after induction was 1.68 cm and decreased to 1.33 cm, the concentration of 5% after induction was 1 , 79 cm and decreased to 1.35 cm. Data were statistically analyzed using ANOVA showing that the negative HPMC controls did not show any anti-inflammatory effects. It can show that 1%, 3% and 5% Red Ginger ethanol extract gel has anti-inflammatory effects and the greatest effect is that the 5% concentration has an anti-inflammatory effect.

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