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All Journal Jurnal Inovasi Teknik Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Ni Ketut Esati
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Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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ISOLASI DAN IDENTIFIKASI SENYAWA FLAVONOID FRAKSI ETIL ASETAT EKSTRAK DAUN AFRIKA (Vernonia amygdalina Del.) Ni Ketut Esati; I Putu Eka Budiarta; Kadek Duwi Cahyadi; Gusti Ayu Dewi Lestari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (452.597 KB) | DOI: 10.36387/jiis.v6i2.741

Abstract

African leaves (Vernonia amygdalina Del.) are reported to have activity as anti-malarial, antibacterial, anticancer, antioxidant, and others. This is closely related to the secondary metabolite compounds, that are contained in african leaves. One of the secondary metabolites that have a big role in the efficacy of african leaves is flavonoids. So that the purpose of this study, to isolated and identified the flavonoid compounds from african leaves. The plants were picked directly in the Tabanan area, Bali. The stages of this study were making the ethanol extract of african leaves, skrinning of the secondary metabolite compounds from the ethanol extract of african leaves. After that, the isolation and purification of flavonoids in ethyl acetate fraction from extract of african leaves are doing. Then the isolate of flavonoid compounds are identified using Ultra Violet-Visible (UV-Vis) and Infrared (IR) spectrophotometer methods. From the results of this study, the yield of ethanol extract was 3.693% derived from maceration of African leaf simplicia powder using 96% ethanol as solvent. The results of phytochemical screening, African leaf ethanol extract contains alkaloids, flavonoids, phenolic compounds, steroids, and saponins. The results of the fractionation obtained n-hexane fraction as much as 2.57 grams, ethyl acetate fraction 0.53 grams, and water fraction as much as 3.02 grams. The flavonoid compounds in the ethyl acetate fraction were separated and isolated, resulting in 2 isolates which were further identified by UV-Vis and IR spectrophotometry. The results obtained with the addition of shear reagents that the ethyl acetate fraction contains flavonoids of the flavone group (7-hydroxyl free), and on examination by IR spectrophotometry showed the presence of OH groups, aliphatic CH, C=O, aromatic C=C, CO alcohol, and aromatic CH.
PENGUJIAN KUALITAS MINYAK KEMIRI (Aleurites moluccana) YANG DIHASILKAN DARI PROSES RENDERING DAN PENGEPRESAN MEKANIK DARI PRODUSEN ‘MINYAK KEMIRI JERNIH’ Ni Made Widayanti; Gusti Ayu Dewi Lestari; Kadek Duwi Cahyadi; Ni Ketut Esati
Jurnal Inovasi Teknik Kimia Vol. 9 No. 4 (2024)
Publisher : Fakultas Teknik Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/inteka.v9i4.12521

Abstract

Kemiri (Aleurites moluccana) adalah tanaman yang banyak dimanfaatkan oleh masyarakat. Bagian kemiri yang sering dimanfaatkan oleh masyarakat adalah bagian biji yang digunakan untuk memproduksi minyak kemiri. Minyak kemiri diketahui memiliki berbagai manfaat, seperti menyuburkan rambut dan mengobati masalah kulit. Penelitian ini bertujuan untuk menganalisis mutu dan kandungan asam lemak pada minyak kemiri yang dihasilkan melalui dua metode ekstraksi, yaitu dengan proses rendering dan proses pengepresan mekanik. Analisis mutu minyak kemiri dilakukan berdasarkan parameter Standar Nasional Indonesia (SNI 01-4462-1998) yang meliputi uji organoleptis, bobot jenis, indeks bias, kadar air, bilangan penyabunan, bilangan iod, dan uji asam lemak bebas. Selain itu, dilakukan pula analisis terhadap komposisi asam lemak menggunakan GC-MS (Gas Chromatography Mass Spectrofotometry) untuk mengidentifikasi dan mengukur proporsi asam lemak tak jenuh yang terdapat dalam minyak kemiri. Hasil penelitian menunjukkan bahwa minyak kemiri yang diekstraksi melalui kedua metode tersebut memenuhi standar mutu yang ditetapkan oleh SNI. Minyak kemiri yang diekstraksi dengan metode pengepresan mekanik memiliki kualitas yang lebih baik dibandingkan dengan metode rendering, ditunjukkan oleh nilai bilangan asam dan kadar air yang lebih rendah. Kedua metode tersebut menghasilkan minyak kemiri dengan kandungan utama asam lemak tak jenuh namun memiliki kadar yang berbeda yaitu asam linoleat 29,76% untuk minyak kemiri dari proses rendering dan 50,92% untuk minyak kemiri dari proses pengepresan mekanik”
IDENTIFIKASI KONTAMINAN TIMBAL DENGAN ELEKTRODA KERJA PASTA KARBON TERMODIFIKASI Ni Ketut Esati; Kadek Duwi Cahyadi
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.409

Abstract

This research identified lead (Pb) contaminants in vegetables. The measurement method used was anodic stripping voltammetry (ASV) with a working electrode of carbon paste modified acid-activated natural zeolite. The stages of the research were formulation of the working electrode, validation of the measurement method and measurement of lead levels in vegetables. The result showed that the optimum formulation of working electrode gave the highest measurement peak current. The optimum formulation with composition of graphite: liquid paraffin: acid activates zeolite is 100:35:10. This electrode was used for determination linear range concentration, limit of detection, percent recovery, and repeatability. The measurement of Pb using electrode by ASV method which gave valid results. It can be seen from a wide concentration range from 50-3000 ppb, a low detection limit of 55.28 ppb, good accuracy and precision. The application of this method is to measure Pb levels in vegetables, and the result is 1.43 mg/Kg.
EFEK EKSTRAK ETANOL AKAR CAKAR SETAN (Martynia annua L) TERHADAP AKTIVITAS SGPT DAN SGOT PADA TIKUS YANG DIINDUKSI CCl4 Elisabeth Oriana Jawa La; Repining Tiyas Sawiji; Ni Ketut Esati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.414

Abstract

SGPT and SGOT activity from ethanol extract of cakar setan root (Martynia annua L) was investigated. Phytochemical screening was carried out on ethanol extract of cakar setan root (Martynia annua L). The animals were grouped into five groups which consist of 5 rats for each group. The normal/healthy group was only given food and drink the negative control group was given an aqueous suspension of 1 % CMC , the positif control group was given tablets Curcuma at a dose of 200 mg/Kg BB, the group ethanol extract Martynia annua L were each given extract at a dose of 200 mg/Kg BB and 400 mg/Kg BB. All groups were treated for 21 days orally. On day 22 were given injection of CCl4 1.0 mL/kg intraperitoneally except healthy group. The rats blood was taken and analyzed through eye orbitalis sinus AST and ALT activities. The result were statistically analyzed using One Way ANOVA test followed by LSD test. Phytochemical screening ethanolic extract of Martynia annua L root positively contains flavonoids, alkaloids, tannin, phenolic, and terpenoids. The result study that ethanol extract of cakar setan root (Martynia annua L) has hepatoprotective effect of being able to reduce activities of SGPT and SGOT in CCl4 induce white rats.
Co-Authors Elisabeth Oriana Jawa La Gusti Ayu Dewi Lestari I Putu Eka Budiarta Kadek Duwi Cahyadi Ni Made Widayanti Repining Tiyas Sawiji