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All Journal JURNAL FARMASIMED (JFM) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Repining Tiyas Sawiji
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Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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EFEK EKSTRAK ETANOL AKAR CAKAR SETAN (Martynia annua L) TERHADAP AKTIVITAS SGPT DAN SGOT PADA TIKUS YANG DIINDUKSI CCl4 Elisabeth Oriana Jawa La; Repining Tiyas Sawiji; Ni Ketut Esati
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 7 No. 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.414

Abstract

SGPT and SGOT activity from ethanol extract of cakar setan root (Martynia annua L) was investigated. Phytochemical screening was carried out on ethanol extract of cakar setan root (Martynia annua L). The animals were grouped into five groups which consist of 5 rats for each group. The normal/healthy group was only given food and drink the negative control group was given an aqueous suspension of 1 % CMC , the positif control group was given tablets Curcuma at a dose of 200 mg/Kg BB, the group ethanol extract Martynia annua L were each given extract at a dose of 200 mg/Kg BB and 400 mg/Kg BB. All groups were treated for 21 days orally. On day 22 were given injection of CCl4 1.0 mL/kg intraperitoneally except healthy group. The rats blood was taken and analyzed through eye orbitalis sinus AST and ALT activities. The result were statistically analyzed using One Way ANOVA test followed by LSD test. Phytochemical screening ethanolic extract of Martynia annua L root positively contains flavonoids, alkaloids, tannin, phenolic, and terpenoids. The result study that ethanol extract of cakar setan root (Martynia annua L) has hepatoprotective effect of being able to reduce activities of SGPT and SGOT in CCl4 induce white rats.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SEDIAAN BODY BUTTER EKSTRAK ETANOL UMBI BIT (Beta vulgaris L.) DENGAN METODE DPPH Repining Tiyas Sawiji; Elisabeth Oriana Jawa La
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.533

Abstract

Beetroot (Beta vulgaris L.) is a plant that contains betasianin (purple pigment) and betasantin (yellow pigment) which makes the color of beets dark red to purplish. The fruit contains a small amount of flavonoid compounds (anthocyanins) which have antioxidant activity. This study aims to develop a body butter formulation of ethanol extract of beetroot (Beta vulgaris L.) as an antioxidant and to see the antioxidant activity with the DPPH immersion method. Extraction of beets used the maceration method using 70% ethanol as a solvent. The antioxidant activity test formula was measured using UV-Vis spectrophotometry with a wavelength of 520 nm. The results showed that formula I obtained an IC50 value of 240 µg/mL (AAI = 0.16), formula II obtained an IC50 value of 139.93 µg/mL (AAI = 0.28), and formula III obtained an IC50 value of 133.34 µg/mL (AAI = 0.29). The higher the antioxidant concentration of the fruit ethanol extract body butter preparation, the smaller the IC50 value, and the greater the AAI value obtained. Based on the results obtained, the antioxidants from the beetroot ethanol extract body butter were still able to fight free radicals at a weak level.
FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN BODY LOTION EKSTRAK KOPI ROBUSTA (Coffea canephora) DENGAN METODE DPPH (2,2-difenil-1-pikrilhidrazil): English; Indonesia Repining Tiyas Sawiji; Elisabeth Oriana Jawa La; I Komang Tri Musthika
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 2 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i2.629

Abstract

The skin is the outermost part of the body and is very susceptible to exposure to free radicals. This can be prevented by using cosmetics that contain antioxidants. Coffee beans have the chemical compound chlorogenic acid which belongs to the phenolic group which is useful as an antioxidant. The purpose of this study was to formulate and test the antioxidant activity of Robusta coffee extract body lotion preparations.The method used is pure experiment and control class as a comparison. Analysis of physical quality data was carried out by means of descriptive analysis using tables based on the results of the average calculation of the physical quality test, antioxidant test using DPPH method, and statistical processing of hedonic test data using the One Way Anova test and continued with the Duncan test. The results showed that FII and FIII could be formulated into body lotion preparations and met the physical quality test requirements. The antioxidant test before storage obtained the IC50 value at FI of 47,61 ppm (AAI = 0,84); FII of 43,86 ppm (AAI = 0,91); and FIII of 34,07 ppm (AAI = 1,17) and after FI storage of 49,95 ppm (0,80); FII of 45,47 (AAI = 0,88); FIII of 36,11 ppm (AAI = 1,11). The results of the hedonic test showed that in the parameters of colour, aroma, texture, and comfort of use there were significant fifferences (<0,05), while the parameters of humidity and ease of rinsing alowed insignificant differences (>0,05). Based on the results obtained, Robusta coffee extract body lotion is able to ward off free radicals in the medium – strong category.
Antipyretic Activity Test of 70% Ethanol Extract of Red Andong Leaves (Cordyline fruticosa (L) A. Chev) in Male Wistar Rats (Rattus norvegicus) Jawa La, Elisabeth Oriana; Salma, Cut Asyifa Baezura Mangkurat; Ni Ketut Esati; Repining Tiyas Sawiji
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/cjzzj881

Abstract

Introduction: Fever is a common health problem that can cause discomfort and may lead to serious complications. One alternative treatment for fever is the use of herbal plants that have been proven to possess antipyretic effects, such as red to plant leaves (Cordyline fruticosa (L.) A. Chev). Objective: To evaluate the secondary metabolite content and assess the antipyretic activity of 70% ethanol extract of red ti plant leaves in male Wistar rats induced with fever using 5% peptone. Methodology: This research used a completely randomized design (CRD) with five treatment groups: a negative control group (1% Na-CMC), a positive control group (paracetamol at a dose of 500 mg/kgBW), and three test groups receiving 70% ethanol extract of red ti plant leaves at doses of 1,200 mg/kgBW, 1,800 mg/kgBW, and 2,400 mg/kgBW. Antipyretic activity was assessed by measuring the reduction in body temperature of the test animals, expressed as a percentage of antipyretic power, and statistically analyzed to evaluate the antipyretic effect of the extract. Results: The study showed that the 70% ethanol extract of red to plant leaves tested positive for flavonoids, tannins, and saponins, which are potential antipyretic compounds. Additionally, the extract demonstrated significant antipyretic activity, as indicated by a notable reduction in the body temperature of the test animals. All three doses of the extract resulted in a temperature decrease, with the 2,400 mg/kgBW dose showing the most optimal antipyretic effect, approaching the effectiveness of paracetamol as the positive control. Conclusion: The 70% ethanol extract of red ti plant leaves has been proven to exhibit antipyretic activity, with the 2,400 mg/kgBW dose demonstrating an effect comparable to paracetamol. The extract also contains secondary metabolites such as flavonoids, tannins, phenol, terpenoids and saponins.
Co-Authors Esati, Ni Ketut I Komang Tri Musthika Jawa La, Elisabeth Oriana Salma, Cut Asyifa Baezura Mangkurat