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All Journal Nexus Kedokteran Klinik Berita Kedokteran Masyarakat
Valentina Lakhsmi Prabandari
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Medicine & Pharmacology Nursing Public Health

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Hubungan Antara Kadar Feritin Dengan Kadar ALT dan AST Pada Pasien Thalasemia di RSUD Dr. Moewardi Prabandari, Valentina Lakhsmi; Riza, Muhammad; Wijayanti, Lilik
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Thalassemia major patients need a regular blood transfusion that may cause an iron overload and vital organ dysfunction. This was an observational analytic study to analyze the relationship between ferritin level and transaminase enzymes level in thalassemia patients at Dr.Moewardi General Hospital. A positive relation may remind doctor to pay attention of liver function in thalassemia major patients. Methods: The research was an observational analytic study with cross sectional approach during April-June 2013 in Dr. Moewardi General Hospital. The samples was taken using exhaustive sampling and all were children with beta thalasemia major. These patients had a regular blood transfusion, high ferritin level (>1000 ng/l) and iron chelating agents usage. Ferritin level as independent variable was measured with ELFA method. Transaminase enzymes as dependent variables were measured with IFCC method. These variables were analyzed with Pearson correlation, diagnostic odds ratio and linier regression. Results: Thirty thalassemia patients’ test results of ferritin, ALT and AST level were collected. Eighteen patients had a very high ferritin level (≥3000 ng/l) and the other twelve patients’ ferritin level were between 1000-3000 ng/l. Eighteen patients had a high ALT level and seventeen patients had a high AST level. Pearson analysis showed a significant result between ferritin and ALT level (p=0.043) also between ferritin and AST level (p=0.028). Pearson correlation strengths were moderate (0.373 and 0.401). Odds ratio between ferritin level with ALT and AST level were 3.333 and 3.111. Conclusions: There was a positively moderate correlation between ferritin level and both ALT and AST level in thalassemia patients in Dr. Moewardi General Hospital. Odds ratio analysis showed that ferritin level above 3000 ng/l is a risk factor of ALT and AST level elevation. Keywords: Thalassemia, iron overload, ferritin, transaminase 
Hubungan Antara Kadar Feritin Dengan Kadar ALT dan AST Pada Pasien Thalasemia di RSUD Dr. Moewardi Valentina Lakhsmi Prabandari; Muhammad Riza; Lilik Wijayanti
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background: Thalassemia major patients need a regular blood transfusion that may cause an iron overload and vital organ dysfunction. This was an observational analytic study to analyze the relationship between ferritin level and transaminase enzymes level in thalassemia patients at Dr.Moewardi General Hospital. A positive relation may remind doctor to pay attention of liver function in thalassemia major patients. Methods: The research was an observational analytic study with cross sectional approach during April-June 2013 in Dr. Moewardi General Hospital. The samples was taken using exhaustive sampling and all were children with beta thalasemia major. These patients had a regular blood transfusion, high ferritin level (>1000 ng/l) and iron chelating agents usage. Ferritin level as independent variable was measured with ELFA method. Transaminase enzymes as dependent variables were measured with IFCC method. These variables were analyzed with Pearson correlation, diagnostic odds ratio and linier regression. Results: Thirty thalassemia patients test results of ferritin, ALT and AST level were collected. Eighteen patients had a very high ferritin level (?3000 ng/l) and the other twelve patients ferritin level were between 1000-3000 ng/l. Eighteen patients had a high ALT level and seventeen patients had a high AST level. Pearson analysis showed a significant result between ferritin and ALT level (p=0.043) also between ferritin and AST level (p=0.028). Pearson correlation strengths were moderate (0.373 and 0.401). Odds ratio between ferritin level with ALT and AST level were 3.333 and 3.111. Conclusions: There was a positively moderate correlation between ferritin level and both ALT and AST level in thalassemia patients in Dr. Moewardi General Hospital. Odds ratio analysis showed that ferritin level above 3000 ng/l is a risk factor of ALT and AST level elevation. Keywords: Thalassemia, iron overload, ferritin, transaminase
Addressing COVID-19 pandemic implication on mental health in community: Perspective towards important issue behind the crisis Prabandari, Valentina Lakhsmi
BKM Public Health and Community Medicine PHS8 Accepted Abstracts
Publisher : Universitas Gadjah Mada

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Abstract

Objective: COVID-19 pandemic gives rise to various health problems experienced by everyone in a community, not only physical condition but also psychosocial condition. COVID-19 was stated to be associated with an increased risk of psychiatric disorders. Nevertheless, besides the stigma on COVID-19, COVID-19 survivors may avoid being open and aware of their mental health condition because of public stigma on mental health. This might lead to late management of mental health and psychosocial issues. The purpose of this initiative was to give a view of the management of mental health care and psychosocial support by empowering the role of community and Puskesmas as one of the closest parts of the health system to the community. Content: Mental health has been the concern of health programs done by Puskesmas through promotive, preventive, curative, and rehabilitative efforts. One measure to be done is to perform monitoring of mental health status of COVID-19 survivors using digital health instruments. Mobile phone-based monitoring might allow early detection and treatment toward mental or psychosocial issues experienced by COVID-19 survivors. Promotive and preventive messages can be shown at the end of the questionnaire. Furthermore, there should be a program designed to develop community-based mental health support by implementing DKJPS (Dukungan Kesehatan Jiwa dan Psikososial) through a collaboration of Puskesmas, community health workers, and other public as well as private sectors. This might be achieved by training and mentoring. The last but not least, there is a need to strengthen the capability of Puskesmas in handling mental health and psychosocial issues by sending psychiatrists or psychologists down to Puskesmas. It doesn’t necessarily mean that they have to be there all the time, but improvement of the capacity of health workers in Puskesmas, as well as consultation and mentoring, are all important needs.
Co-Authors Lilik Wijayanti Lilik Wijayanti Muhammad Riza Muhammad Riza