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All Journal EKSAKTA: Journal of Sciences and Data Analysis Jurnal Ilmu Dasar Teknosains: Media Informasi Sains dan Teknologi Biology, Medicine, & Natural Product Chemistry Indonesian Journal of Chemistry Aplikasia: Jurnal Aplikasi Ilmu-Ilmu Agama ALKIMIA : Jurnal Ilmu Kimia dan Terapan
Susy Yunita Prabawati
Program Studi Kimia, Fakultas Sains Dan Teknologi, UIN Sunan Kalijaga Yogyakarta Jl. Laksda Adisucipto, Yogyakarta
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Environmental Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Jurnal Ilmu Dasar

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Synthesis of Compounds Acetyl Vanilat as Analgesic Compound Components Iskandar, Damayanti; Prabawati, Susy Yunita
Jurnal ILMU DASAR Vol 17 No 2 (2016)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.098 KB) | DOI: 10.19184/jid.v17i2.2683

Abstract

Acetyl vanillate was synthesized to become an analgesic compound was conducted in two stages.The first stage is oxidation vanillin using Tollens reagent. The result of the oxidation wascharacterized by melting point and FTIR. The second stage, vanillic acid was acetylated usingacetic acid anhydrous under two conditions, that are acid and base using H2SO4 and NaOH 10%,respectively. Two difference products from those processes were characterized using FTIR and1H-NMR. The result of the melting point vanillic acid test showed 204°C and the standard is210°C. Vanilline was successfully oxidized, based on comparison FTIR spectra between vanillineand its precursor that showed no functional group of C-H aldehyde at 2,700-2,800 cm-1. Thecharacteristics FTIR spectra under base conditions showed no absorption of functional group ‒OHthat substituted by an acetyl group. So that, the base catalyst indicated no product of the expectedcompound. The product under acidic compounds have the characteristic yellow crystals with amelting point of 130°C. Characteristics of FTIR showed no width absorption at wave number 3400cm-1 and evidenced by 1H-NMR spectra. Shift peak at 2.342 ppm was an absorption acetylcompounds. It was concluded that acetylation of acetyl vanillate compounds under acidicconditions to produce the expected product.Keywords: vanilin, vanilic acid, acetylation
Co-Authors Abdul Aziz Astuti, Ratih Dwi Damayanti Iskandar Diza Harris Pratiwi Imelda Fajriati Jumina Jumina Mufidati, Afifah Mustofa Mustofa Nur Ngaini, Siti Ratna Djuwita, Titis Risnandar, Ade Irfan Sri Juari Santosa Triatmaja, Karisma Widiakongko, Priyagung Dhemi Wulandari, Teti Wulan