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AKTIVITAS EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) PADA RADIAL ARM MAZE DAN PASIVE AVOIDANCE TEST TIKUS MODEL DEMENSIA Prasetya, Didik Yuni; Yuliani, Sapto
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma xanthorrhiza Roxb. is a plant containing curcumin. Curcumin has been shown toreduce oxidative damage and memory deficits associated with aging. The aim of the researchwas to know the effect of Curcuma xanthorrhiza Roxb. rhizome ethanol extract to memoryfunction on Wistar rats induced by trimethyltin. The research design was post test onlycontrolled group with 42 rats divided into 6 groups, Each group consist of 7 rats. Group I(healthy controls) were given a solution of 0.5% CMC-Na orally. Group II (negative control)were given a solution of 0.5% CMC-Na orally. Group III, IV, and V were given Curcuma xanthorrhiza Roxb. extract each 120 mg/kgBW, 240 mg/kgBW, and 480 mg/kgBW orally.Group VI (positive control) were given piracetam 500 mg/kgBW intraperitoneally. All groupswere given trimethyltin intraperitoneally except group I. Data indicating memory function wereobtained from radial maze test and passive avoidance test. Radial maze test data were analyzedby ANOVA followed by LSD test, while the passive avoidance test data were analyzed with theKruskal Wallis test followed by Mann-Whitney test. In conclusion, ethanol extract oftemulawak rhizome (Curcuma xanthorrhiza Roxb.) at doses of 120 mg/kgBW, 240 mg/kgBWand 480 mg/kgBW can prevent memory function decline on Wistar rats induced bytrimethyltin.

AKTIVITAS EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) PADA RADIAL ARM MAZE DAN PASIVE AVOIDANCE TEST TIKUS MODEL DEMENSIA Didik Yuni Prasetya; Sapto Yuliani
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma xanthorrhiza Roxb. is a plant containing curcumin. Curcumin has been shown toreduce oxidative damage and memory deficits associated with aging. The aim of the researchwas to know the effect of Curcuma xanthorrhiza Roxb. rhizome ethanol extract to memoryfunction on Wistar rats induced by trimethyltin. The research design was post test onlycontrolled group with 42 rats divided into 6 groups, Each group consist of 7 rats. Group I(healthy controls) were given a solution of 0.5% CMC-Na orally. Group II (negative control)were given a solution of 0.5% CMC-Na orally. Group III, IV, and V were given Curcuma xanthorrhiza Roxb. extract each 120 mg/kgBW, 240 mg/kgBW, and 480 mg/kgBW orally.Group VI (positive control) were given piracetam 500 mg/kgBW intraperitoneally. All groupswere given trimethyltin intraperitoneally except group I. Data indicating memory function wereobtained from radial maze test and passive avoidance test. Radial maze test data were analyzedby ANOVA followed by LSD test, while the passive avoidance test data were analyzed with theKruskal Wallis test followed by Mann-Whitney test. In conclusion, ethanol extract oftemulawak rhizome (Curcuma xanthorrhiza Roxb.) at doses of 120 mg/kgBW, 240 mg/kgBWand 480 mg/kgBW can prevent memory function decline on Wistar rats induced bytrimethyltin.

FORMULASI DAN UJI SIFAT FISIK SEDIAAN GEL EKSTRAK ETANOLIK GANGGANG HIJAU (Ulva Lactuca LINN.) Emelda, Emelda; Septiawan, Azizah Nada; Pratiwi, Dinda Ayu; Prasetya, Didik Yuni
Jurnal Insan Farmasi Indonesia Vol 3 No 2 (2020): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v3i2.645

One of the skin diseases that are often experienced by people is acne. The bacteria found in acne are P. acnes, S. aureus, and S. epidermidis. The preparation was chosen in this formulation because it is more practical and durable in storage. Gel preparations were chosen because it dry easily, can form a film layer that is easy to wash, and gives a cool feeling to the skin. Physical stability tests need to be carried out to ensure the quality, safety, and usefulness of the gel so that it meets the expected specifications and is stable in storage. This study aims to make a gel formulation and determine the physical properties of green algae Ethanolic extract gel. The optimum gel formula is determined based on variations in the concentration of Hydroxypropyl methylcellulose. The Gel that meets the criteria of homogeneity, consistency, pH , and dispersibility is determined as the optimum formula. The physical stability of the optimum formula was tested by organoleptic, homogeneity, pH test, spreadability test, and viscosity test. The gel that met the acceptance criteria was green algae ethanolic extract gel with a concentration of 3% HPMC so that it was determined as the optimum formula.

FORMULASI DAN UJI IRITASI SEDIAAN MASKER PEEL OFF GEL KOMBINASI EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DAN KUNYIT PUTIH (Curcuma zedoaria) Putri, Safira Amalia; Annisa Fatmawati; Eva Nurinda; Didik Yuni Prasetya
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 2 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i2.328

Butterfly pea flower (Clitoria ternatea L.) and white turmeric (Curcuma zedoaria) have antioxidant activity and can be combined to make a peel off gel mask. To ensure the quality and safety of the peel off gel mask, it is necessary to evaluate its physical properties and test for irritation. The manufacturing process involves extracting butterfly pea flower and white turmeric using a maceration method using 70% ethanol solvent. The resulting extract was tested for phytochemistry to identify alkaloids, saponins, flavonoids and tannins. The preparation was formulated with variations in extract concentrations: FI (1:3), FII (2:2) and FIII (3:1). Evaluation of physical properties includes organoleptic tests, pH, spreadability, homogeneity, stickiness, drying time and viscosity. Irritation tests were carried out on New Zealand rabbits. The result indicated that the peel off gel mask with various extract concentrations met most of the physical property evaluation requirements even though the pH test did not meet the standards. The EEBT and EEKP combination peel off gel mask did not cause irritation in New Zealand rabbits during 72 hours of observation.

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