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Gambaran Kadar Troponin T dan Creatinin Kinase Myocardial Band pada Infark Miokard Akut Rendi Dwi Prasetyo; Masrul Syafri; Efrida Efrida
Jurnal Kesehatan Andalas Vol 3, No 3 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i3.171

Abstract

AbstrakInfark Miokard Akut (IMA) adalah kematian sel miokardium akibat terlepasnya plak aterosklerotik dari salah satu arteri koroner yang mencetuskan terjadinya agregasi trombosit, pembentukan trombus, dan spasme koroner. Diagnosis IMA dapat dilakukan dengan cara: anamnesis, abnormalitas Elektrokardiogram (EKG), peningkatan Creatinin Kinase Myocardial Band (CKMB), dan cardiac specific troponin (cTn)T. Diagnosis IMA dapat ditegakkan jika terdapat minimal dua dari tiga kriteria yang harus dipenuhi, yaitu: anamnesis, abnormalitas EKG, dan peningkatan aktivitas enzim jantung. Tujuan penelitian ini adalah untuk mengetahui gambaran kadar troponin T dan CKMB pada pasien IMA di RS. Dr. M. Djamil Padang periode 1 Januari 2012 - 31 Desember 2012. Penelitian dilakukan secara retrospektif deskriptif terhadap 54 sampel rekam medik pasien IMA yang dirawat inap di bagian penyakit dalam dan jantung RS. Dr. M. Djamil Padang periode 1 Januari 2012 - 31 Desember 2012. Kadar troponin T diperiksa dengan metode chemiluminescent dan CKMB diperiksa dengan metode enzymatic immunoassay with serum start. Hasil penelitian ini menunjukkan umur terbanyak pasien IMA adalah 40-60 tahun berjumlah 30 orang (55,56%). Jenis kelamin terbanyak pasien IMA adalah laki-laki berjumlah 39 orang (72,22%). Pasien IMA yang memiliki kadar CKMB ≥24 U/L berjumlah 35 orang (64,82%). Pasien IMA yang memiliki kadar troponin T ≥0,1 ng/mL berjumlah 44 orang (81,48%). Didapatkan peningkatan kadar troponin T dan CKMB pada pasien IMA.Kata kunci: infark miokard akut, troponin t, CKMBAbstractAcute Myocardial Infarction (AMI) is a muscle necrosis of the heart caused by rupture atherosclerotic plaque from one of coronary artery that cause platelet aggregation, thrombus formation, and coronary spasm. Diagnosis of AMI can be made by some way : anamnesis, electrocardiogram (ECG) abnormalities, increase levels of creatinine kinase myocardial band (CKMB) and cardiac specific troponin (cTn)T. Diagnosis of AMI can be established if obtained at least two of three criteria : anamnesis, ECG abnormalities and increase of levels cardiac enzymes. The objective of this study was to determine the troponin T levels and CKMB in AMI at RS. Dr. M. Djamil Padang period January 1st, 2012 - December 31th, 2012. The study was conducted with retrospective descriptive with 54 medical records sample of treated patients AMI at internal medicine and cardiology department of RS. Dr. M. Djamil Padang from January 1st, 2012 - December 31th 2012. Troponin T level checked with chemiluminescent method and CKMB checked with enzymatic immunoassay with serum start method. The results of this study indicate that the most age of the patients of AMI are 40-60 years old, 30 people (55,56%). The most gender of AMI are male, 39 people (72,22%). Patients AMI with CKMB levels ≥24 U/L are 35 people (64,82). Patients AMI with troponin T levels ≥0,1 ng/mL are 44 people (81,48%). There are increased in troponin T levels and CKMB in patients of AMI.Keywords: acute myocardial infarction, troponin t, ckmb
Unfractionated Heparin versus Low Molecular Weight Heparin for Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients: A Meta-analysis Rendi Dwi Prasetyo; Rudy Afriant
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1287

Abstract

Background: Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in acutely ill medical patients. Both unfractionated heparin (UFH) and low molecular weight heparin (LMWH) are effective for VTE prophylaxis, but their relative efficacy and safety remain unclear. Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) comparing UFH and LMWH for VTE prophylaxis in acutely ill medical patients. We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from 2013 to 2024. The primary outcome was the incidence of VTE. Secondary outcomes included major bleeding and mortality. Results: Seven RCTs with a total of 5,412 patients were included. LMWH was associated with a significantly lower risk of VTE compared to UFH (relative risk [RR] 0.68; 95% confidence interval [CI] 0.52-0.88; p = 0.004). There was no significant difference in major bleeding (RR 0.91; 95% CI 0.65-1.27; p = 0.58) or mortality (RR 0.93; 95% CI 0.78-1.11; p = 0.43) between the two groups. Conclusion: LMWH is more effective than UFH for VTE prophylaxis in acutely ill medical patients without increasing the risk of major bleeding or mortality. LMWH should be considered the preferred agent for VTE prophylaxis in this population.
Unfractionated Heparin versus Low Molecular Weight Heparin for Venous Thromboembolism Prophylaxis in Acutely Ill Medical Patients: A Meta-analysis Rendi Dwi Prasetyo; Rudy Afriant
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1287

Abstract

Background: Venous thromboembolism (VTE) is a significant cause of morbidity and mortality in acutely ill medical patients. Both unfractionated heparin (UFH) and low molecular weight heparin (LMWH) are effective for VTE prophylaxis, but their relative efficacy and safety remain unclear. Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) comparing UFH and LMWH for VTE prophylaxis in acutely ill medical patients. We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from 2013 to 2024. The primary outcome was the incidence of VTE. Secondary outcomes included major bleeding and mortality. Results: Seven RCTs with a total of 5,412 patients were included. LMWH was associated with a significantly lower risk of VTE compared to UFH (relative risk [RR] 0.68; 95% confidence interval [CI] 0.52-0.88; p = 0.004). There was no significant difference in major bleeding (RR 0.91; 95% CI 0.65-1.27; p = 0.58) or mortality (RR 0.93; 95% CI 0.78-1.11; p = 0.43) between the two groups. Conclusion: LMWH is more effective than UFH for VTE prophylaxis in acutely ill medical patients without increasing the risk of major bleeding or mortality. LMWH should be considered the preferred agent for VTE prophylaxis in this population.
Administrative and Topographic Map of Kelurahan to Support Land Efficiency and Flood Mitigation Refrizon; Farid, Mochammad; Ekawita, Riska; Fauzi, Hera Wahyu; Anggria, Della Cici; Prasetyo, Rendi Dwi
Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2024): Jurnal Pengabdian Masyarakat
Publisher : Institut Teknologi dan Bisnis Asia Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32815/jpm.v5i2.1779

Abstract

Purpose: The community service activity by the University of Bengkulu Geophysics and Physics Team aimed to assist the community of Kandang Limun, Bengkulu City, by developing maps that display area boundaries and topographical elevations. The maps were intended to serve as easily accessible sources of information for the local community and to aid in planning and development efforts.Method: The methodology involved conducting a preliminary survey, collecting data, preparing software tools, and creating both boundary and topographic maps. A questionnaire was distributed to assess community satisfaction with the project.Practical Applications: The maps provide valuable information for local government and residents, serving as a resource for defining area boundaries and understanding topographical features. These maps are particularly useful for urban planning, land use, and community development initiatives.Conclusion: The creation and public display of administrative and topographical maps in the Kelurahan office have improved access to essential geographical information. This initiative supports better community planning and contributes to the informed development of the area, benefiting both the local government and residents.