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Hubungan Umur dan Lamanya Hemodialisis dengan Status Gizi pada Penderita Penyakit Ginjal Kronik yang menjalani Hemodialisis di RS. Dr. M. Djamil Padang Hannie Qalbina Syaiful; Fadil Oenzil; Rudy Afriant
Jurnal Kesehatan Andalas Vol 3, No 3 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i3.144

AbstrakPenyakit Ginjal Kronik (PGK) masih merupakan masalah kesehatan dunia karena prevalensinya yang meningkat, “ireversible” dan progresif. Malnutrisi lebih banyak ditemukan pada PGK. Sebanyak 40% malnutrisi ditemukan pada penderita pada awal hemodialisis. Penelitian ini bertujuan untuk melihat hubungan umur dan lamanya hemodialisis dengan status gizi pada penderita penyakit ginjal kronik yang menjalani hemodialisis. Ini adalah suatu penelitian Cross Sectional Study yang dilakukan pada bulan Oktober 2013 di Unit Hemodialisis RS Dr. M. Djamil Padang. Telah Diteliti sebanyak 59 orang penderita PGK. Penilaian gizi diukur dengan Lingkaran Lengan Atas (LILA) dan Tebal Lipat Kulit (Skin Fold). Data dianalisa dengan program SPSS. Hasil penelitian memperlihatkan bahwa umur penderita berkisar 22-75 tahun dengan rata-rata 52,39 ±10,39 tahun dan terbanyak umur 50-59 tahun yaitu sebesar 50,86%. Lamanya menjalani hemodialisis berkisar 1-97 bulan dengan rata-rata 24,54 ± 24,69 bulan. Malnutrisi pada penderita PGK berdasarkan LILA dan Skin Fold, didapatkan berturut-turut 33 orang (55,93%) dan32 orang (54,24%). Tidak didapatkan hubungan yang bermakna antara gambaran gizi dengan umur dan lamanya menjalani hemodialisis (p>0,05, r<1). Kesimpulan dari studi ini adalah malnutrisi pada PGK yang menjalani hemodialisis berkisar antara 54,24% – 55,93%. Tidak terdapat hubungan antara status gizi dengan umur dan lamanya menjalani hemodialisisKata kunci: PGK, malnutrisi, umurAbstractChronic Kidney Disease (CKD) is still a global health problem due to its increasing prevalence Its irreversible and progressive state. Malnutrition is more common in CKD patients. A total of 40% malnutrition case is found in patients at the beginning of their hemodialysis. The objective of this study was to observe the relationships of age and duration of hemodialysis with regard to nutritional status in chronic kidney disease patient on hemodialysis. This was a cross sectional study conducted in October 2013 at Hemodialysis Unit of Dr. M. Djamil General Hospital, Padang. A total of 59 patients with CKD were analyzed. Nutritional assessment was measured by Upper Arm Circles (UAC) and Skin Fold’s thickness (Skin Fold). Data were analyzed using SPSS. Results: Ages of patients were ranged from 22-75 years with an average of 52.39 ± 10.39 years, and most patients were aged 50-59 years that was equal to 50.86%. The long of hemodialysis was ranged 1-97 months with an average of 24.54 ± 24.69 months. Malnutrition in patients with CKD based on UAC and Skin Fold were obtained successively in 33 people (55.93%) and 32 people (54.24%). There was no significant association between nutritional figure with age and duration of hemodialysis (p>0.05, r<1). Conclusion from ths study is malnutrition in CKD patients that undergo hemodialysis is ranged from 54.24% to 55.93%. There is no relationship between nutritional status with age and duration of undergoing hemodialysis.Keyword: CKD, Malnutrition, age

Faktor Risiko Terjadinya Ulkus Diabetikum pada Pasien Diabetes Mellitus yang Dirawat Jalan dan Inap di RSUP Dr. M. Djamil dan RSI Ibnu Sina Padang Rizky Loviana Roza; Rudy Afriant; Zulkarnain Edward
Jurnal Kesehatan Andalas Vol 4, No 1 (2015)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v4i1.229

AbstrakUlkus diabetikum adalah keadaan ditemukannya infeksi, tukak dan atau destruksi ke jaringan kulit yang paling dalam di kaki pada pasien Diabetes Mellitus (DM) akibat abnormalitas saraf dan gangguan pembuluh darah arteri perifer. Ulkus diabetikum dapat dicegah dengan melakukan intervensi sederhana sehingga kejadian angka amputasi dapat diturunkan hingga 80%. Amputasi memberikan pengaruh besar terhadap seorang individu, tidak hanya dari segi kosmetik tapi juga kehilangan produktivitas, meningkatkan ketergantungan terhadap orang lain serta biaya mahal yang dikeluarkan untuk penyembuhan. Penelitian ini memberikan pengetahuan tentang faktor risiko terjadinya ulkus diabetikum agar angka mortalitas dan morbiditas dapat di kurangi. Jenis penelitian ini adalah retrospektif observasional dengan mengumpulkan data menggunakan wawancara, kuisoner, dan pemeriksaan fisik pada pasien diabetes mellitus yang di rawat jalan dan inap di RSUP DR. M. Djamil dan RSI Ibnu Sina Padang periode Januari-Maret 2014. Analisis data terhadap 6 variabel di dapatkan Jenis kelamin (p =0,595; OR=0,654) lama DM (p=1,000; OR = 1,158), neuropati (p=0,411; OR=1,833), PAD (p=0,004; OR), trauma (p=0, 02; OR= 4), dan perawatan kaki (p=1,000; OR=1,158). Berdasarkan uji statistik Chi-Square didapatkan 2 variabel yang memiliki hubungan bermakna dengan kejadian ulkus diabetikum yaitu PAD dan trauma. Sedangkan, hasil uji statistik regresi logistik ganda menyatakan bahwa lama DM, neuropati, PAD, riwayat trauma, dan perawatn kaki merupakan faktor risiko terjadinya ulkus diabetikum. PAD dan trauma adalah faktor yang paling berpengaruh.Kata kunci: faktor risiko, DM, ulkus diabetikumAbstractDiabetic foot ulcer is defined as the presence of infection, ulceration and/or destruction of deep tissues associated with neurologic abnormalities and various degrees of peripheral arterial disease (PAD) in the lower limb on patients with diabetes. Foot ulceration is preventable, and relatively simple interventions can reduce amputations by up to 80%. Amputation has a major impact on individual, not only in distorting body image, but also loss of productivity, increasing dependency, and expensive cost of treating foot ulcer. This study provides knowledge about risk factors for diabetic ulcers that mortality and morbidity can be reduced. This research is an observational retrospective by collecting data using interviews, questionnaires, and physical examination in patients with diabetes mellitus in outpatient and inpatient department of DR. M. Djamil and RSI Ibnu Sina Padang from January until March 2014. The result from the analyze data from 6 variable known gender (p =0,595; OR=0,654), duration of DM (p=1,000; OR = 1,158), neuropathy (p=0,411; OR=1,833), PAD (p=0,004; OR= 5,5), trauma (p=0,02; OR= 4), and foot care (p=1,000; OR=1,158). Based on Chi-Square test statistic obtained two variables that have a significant relationship with the occurrence of diabetic ulcers is PAD and trauma. Meanwhile, the results of multiple logistic regression statistical tests that the old DM, neuropathy, PAD, history of trauma, and foot care a risk factor for diabetic ulcers. PAD and trauma are the most influential.Keywords: risk factor, DM, diabetic foot ulcer

Hubungan Kadar FT4 dan TSH Serum dengan Profil Lipid Darah pada Pasien Hipertiroid yang Dirawat Inap di RSUP Dr. M. Djamil Padang Tahun 2009 - 2013 Aga Pratama; Eti Yerizel; Rudy Afriant
Jurnal Kesehatan Andalas Vol 3, No 1 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i1.19

AbstrakHipertiroid merupakan sindroma klinis yang terjadi bila jaringan terpajan dengan jumlah hormon tiroid yang berlebihan karena hiperaktivitas kelenjar tiroid. Hal tersebut akan memberikan efek spesifik terhadap metabolisme sel, termasuk metabolisme lipid. Perubahan metabolisme lipid pada hipertiroid akan menimbulkan manifestasi klinis seperti gangguan mood, peningkatan perilaku depresi, dan peningkatan perilaku agresif. Dalam diagnosis pasien hipertiroid, pemeriksaan kadar FT4 dan TSH serum menjadi tes fungsi tiroid yang tepat. Penelitian ini bertujuan untuk melihat bagaimana hubungan antara kadar FT4 dan TSH serum dengan profil lipid darah pada pasien hipertiroid. Penelitian ini menggunakan data deskriptif di Instalasi Rekam Medis RSUP dr. M. Djamil Padang pada bulan Februari 2013 sampai Juli 2013. Data yang dikumpulkan berasal dari catatan rekam medik pasien hipertiroid yang dirawat inap berjumlah 21 orang dengan teknik total sampling. Analisis bivariat digunakan untuk melihat hubungan antara kadar FT4 dan TSH serum dengan profil lipid darah. Dari sampel yang ada diperoleh data rerata profil lipid, yakni: 143,33 mg/dl (kolesterol darah total); 42,06 mg/dl (HDL); 85,45 mg/dl (LDL); dan 77,19 mg/dl (trigliserida). Berdasarkan uji korelasi regresi, terdapat korelasi negatif antara kadar FT4 dengan kadar kolesterol darah total, HDL, dan LDL, tetapi tidak terdapat korelasi antara kadar FT4 dengan trigliserida. Hubungan antara kadar TSH serum dengan kolesterol darah total dan LDL mempunyai korelasi positif, tetapi tidak terdapat korelasi antara kadar TSH serum dengan HDL dan trigliserida. Penelitian ini memperlihatkan bahwa sebagian besar profil lipid darah mempunyai korelasi dengan kadar FT4 dan TSH serum, kecuali trigliserida.Kata kunci: kadar FT4 dan TSH serum, profil lipid darah, hipertiroidAbstractHyperthyroidism is a clinical syndrome that occurs when tissues are exposed by excessive amount of thyroid hormones due to thyroid gland hiperactivity. It has spesific effects on cell metabolism, including lipid metabolism.L ipid metabolism disorder in hyperthyroid will inflict clinical manifestation; such as mood disorders, depression, and increased aggressive behavior. In diagnose patient with hyperthyrodism, FT4 and TSH serum level test are the appropriate thyroid function test. The objective of this study was to determine relationship between FT4 and TSH serum level with blood lipid profile in patient with hyperthyrodism. This studies got the descriptive data in Medical Records Departement of RSUP dr. M. Djamil Padang from February 2013 to July 2013. Data of 21 hyperthyrodism patient were got with total sampling technique. Bivariat analysis is used to examine the relationship between FT4 and TSH serum level with blood lipid profile. From the sampel was obtained data of profile lipid average, that is 143,33 mg/dl (total cholesterol); 42,06 mg/dl (HDL); 85,45 mg/dl (LDL); dan 77,19 mg/dl (triglycerides). Based on the regression test, there was negative correlation between FT4 level with total cholesterol, HDL, and LDL, but, there wasn’t correlation between FT4 level with triglycerides. The relationship between TSH serum level with total cholesterol and LDL had positive correlation. But, there isn’t evidence of correlation between TSH serum level with HDL and triglycerides. This study shows that the most of blood lipid profile has correlation with FT4 and TSH serum level, except triglycerides.Keywords: FT4 and TSH serum level, blood lipid profile, hyperthyrodism

Gambaran Kejadian Retinopati Hipertensi pada Penderita Hipertensi yang Dirawat di Bagian Penyakit Dalam RSUP dr. M. Djamil pada Bulan Januari-Desember 2013 Seilla Dinta Yastina; Rudy Afriant; Yenita Yenita
Jurnal Kesehatan Andalas Vol 6, No 3 (2017)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v6i3.745

Hipertensi bisa mengakibatkan kerusakan pada target organ seperti jantung, ginjal, otak, dan mata. Kerusakan target organ dapat dideteksi dengan melihat gambaran retinopati hipertensi. Pada retinopati hipertensi stadium III dan IV pada klasifikasi Keith-Wagener- arker akan terjadi kerusakan target organ lain dan penurunan visus serta kebutaan. Tujuan penelitian ini adalah untuk mengetahui gambaran kejadian retinopati hipertensi pada penderita hipertensi yang di rawat di Bagian Penyakit Dalam RSUP Dr. M. Djamil. Penelitian ini bersifat deskriptif dengan menggunakan data rekam medik pasien dengan diagnosis hipertensi dari Januari sampai Desember 2013. Seluruh anggota populasi dijadikan sampel sesuai kriteria inklusi dan eksklusi, sehingga diperoleh sampel sebanyak 144 orang. Hasil penelitian yang didapatkan yaitu 46.5% dari penderita hipertensi mendapat retinopati hipertensi. Pada pasien dengan retinopati hipertensi, 65.7% dengan TDS >160 mmHg dan/atau TDD >100 mmHg, 55.2% menderita hipertensi > 5 tahun, 95.5% merupakan kelompok usia > 40 tahun, 62.7% adalah perempuan, dan 62.7% dengan Keith-Wagerner-Barker II. Berdasarkan hasil penelitian ini disimpulkan bahwa sebagian besar pasien retinopati hipertensi dengan Keith-Wagerner-Barker II pada pasien dengan TDS >160 mmHg dan/atau TDD >100 mmHg, menderita hipertensi >5 tahun, dengan umur >40 tahun.

Atypical Chronic Myeloid Leukemia in Pregnancy Rido Wandrivel; Eifel Faheri; Irza Wahid; Rudy Afriant
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.573

Background: Atypical chronic myeloid leukemia was first depicted as a subtype of myeloid neoplasm that closely resembles chronic myeloid leukemia but does not have the pathognomonic Philadelphia chromosome. Chronic myeloid leukemia can also be found in pregnant and fertile women, which means pregnancy can happen at the time of diagnosis or during the treatment of this disease. Case presentation: A 32-year-old woman came to the hemato-oncology polyclinic at M. Djamil General Hospital Padang with the main complaint of weakness and fatigue. The patient was pregnant with a gestational age of 23-24 weeks. On physical examination, the conjunctiva was anemic, and the spleen was palpable S4 (18 cm). On routine blood laboratory examination, the results of anemia, leukocytosis, and on the peripheral blood picture, severe normochromic normocytic anemia was found with pathological cells of 3% myelocytes and 1% metamyelocytes. Conclusion bone marrow puncture (BMP) results follow the description of chronic myeloid leukemia in the chronic phase. Conclusion: During pregnancy, chronic myeloid leukemia has a better prognosis compared to acute leukemia. However, atypical chronic myeloid leukemia still has the potential of leukostasis, causing uteroplacental deficiency and eventually leading to fetal growth restriction, premature birth, and an increase in perinatal mortality.

Atypical Chronic Myeloid Leukemia in Pregnancy Rido Wandrivel; Eifel Faheri; Irza Wahid; Rudy Afriant
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 9 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i9.573

Background: Atypical chronic myeloid leukemia was first depicted as a subtype of myeloid neoplasm that closely resembles chronic myeloid leukemia but does not have the pathognomonic Philadelphia chromosome. Chronic myeloid leukemia can also be found in pregnant and fertile women, which means pregnancy can happen at the time of diagnosis or during the treatment of this disease. Case presentation: A 32-year-old woman came to the hemato-oncology polyclinic at M. Djamil General Hospital Padang with the main complaint of weakness and fatigue. The patient was pregnant with a gestational age of 23-24 weeks. On physical examination, the conjunctiva was anemic, and the spleen was palpable S4 (18 cm). On routine blood laboratory examination, the results of anemia, leukocytosis, and on the peripheral blood picture, severe normochromic normocytic anemia was found with pathological cells of 3% myelocytes and 1% metamyelocytes. Conclusion bone marrow puncture (BMP) results follow the description of chronic myeloid leukemia in the chronic phase. Conclusion: During pregnancy, chronic myeloid leukemia has a better prognosis compared to acute leukemia. However, atypical chronic myeloid leukemia still has the potential of leukostasis, causing uteroplacental deficiency and eventually leading to fetal growth restriction, premature birth, and an increase in perinatal mortality.

The Effectiveness of Antiplatelet Therapy in COVID-19 Patients: A Narrative Literature Review Muhammad Ridhwan Fatharanifurqan; Rudy Afriant; Raveinal; Fauzar; Drajad Priyono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.751

Coagulopathy is a feature of severe COVID-19 disease and contributes to an increased risk of thromboembolic complications and death. This literature review aimed to describe the effectiveness of antiplatelet therapy in COVID-19 patients. There is an inverse relationship between the likelihood of COVID-19 infection, duration of illness and death, and use of antiplatelets for primary prevention. A study showed that COVID-19 patients who did not receive antiplatelet drugs had three times the risk of dying with antiplatelet drugs. This study shows the strong effect of antiplatelet drugs on reducing the mortality rate of COVID-19 patients. Another study showed that COVID-19 patients who received antiplatelet drugs had 1.18 times the risk of dying than those without antiplatelet drugs. This study shows that antiplatelet therapy does not affect the reduction in mortality in patients hospitalized with COVID-19. In conclusion, the effectiveness of antiplatelet administration in COVID-19 patients is still unclear, so further research is needed.

The Effectiveness of Antiplatelet Therapy in COVID-19 Patients: A Narrative Literature Review Muhammad Ridhwan Fatharanifurqan; Rudy Afriant; Raveinal; Fauzar; Drajad Priyono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.751

Coagulopathy is a feature of severe COVID-19 disease and contributes to an increased risk of thromboembolic complications and death. This literature review aimed to describe the effectiveness of antiplatelet therapy in COVID-19 patients. There is an inverse relationship between the likelihood of COVID-19 infection, duration of illness and death, and use of antiplatelets for primary prevention. A study showed that COVID-19 patients who did not receive antiplatelet drugs had three times the risk of dying with antiplatelet drugs. This study shows the strong effect of antiplatelet drugs on reducing the mortality rate of COVID-19 patients. Another study showed that COVID-19 patients who received antiplatelet drugs had 1.18 times the risk of dying than those without antiplatelet drugs. This study shows that antiplatelet therapy does not affect the reduction in mortality in patients hospitalized with COVID-19. In conclusion, the effectiveness of antiplatelet administration in COVID-19 patients is still unclear, so further research is needed.

The Role of Immunophenotyping in the Diagnosis of Acute Leukemia: A Narrative Literature Review Rivani Sintia Suratman; Rudy Afriant; Drajad Priyono; Raveinal; Fauzar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.772

Leukemia is the expansion of leukocyte cells in the bone marrow, which results in an increase in the number of leukocyte cells in the blood circulation and abnormal cell proliferation in the lymphatic tissue. The diagnosis of leukemia is established based on anamnesis, physical examination, and laboratory and confirmed by supporting examinations such as bone marrow aspiration to immunophenotyping. This literature review aimed to describe the role of immunophenotyping in the diagnosis of acute leukemia. The working process of immunophenotyping consists of a group of cells stained with a fluorochrome-conjugated antibody as a dye that is targeted to antigens on the cell surface. Most of these antigens are assigned a cluster of differentiation (CD) numbers. In conclusion, immunophenotyping analysis using multiparameter flow cytometry is an essential tool in detecting leukemia. Immunophenotyping examination is very useful for determining the diagnosis of leukemia. Targeted therapy is one of the modalities of leukemia therapy that is selective for certain cells that can be given based on the results of immunophenotyping.

The Role of Immunophenotyping in the Diagnosis of Acute Leukemia: A Narrative Literature Review Rivani Sintia Suratman; Rudy Afriant; Drajad Priyono; Raveinal; Fauzar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.772

Leukemia is the expansion of leukocyte cells in the bone marrow, which results in an increase in the number of leukocyte cells in the blood circulation and abnormal cell proliferation in the lymphatic tissue. The diagnosis of leukemia is established based on anamnesis, physical examination, and laboratory and confirmed by supporting examinations such as bone marrow aspiration to immunophenotyping. This literature review aimed to describe the role of immunophenotyping in the diagnosis of acute leukemia. The working process of immunophenotyping consists of a group of cells stained with a fluorochrome-conjugated antibody as a dye that is targeted to antigens on the cell surface. Most of these antigens are assigned a cluster of differentiation (CD) numbers. In conclusion, immunophenotyping analysis using multiparameter flow cytometry is an essential tool in detecting leukemia. Immunophenotyping examination is very useful for determining the diagnosis of leukemia. Targeted therapy is one of the modalities of leukemia therapy that is selective for certain cells that can be given based on the results of immunophenotyping.

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