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All Journal Jurnal Kedokteran Gigi Universitas Padjadjaran Paediatrica Indonesiana
Yakub, Kemas M
Department Of Clinical Pathology, Sriwijaya University Medical School/Dr. Mohammad Hoesin Hospital, Palembang, South Sumatera
Dentistry Health Professions Medicine & Pharmacology

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Perbedaan kadar TNF-α saliva pada ibu hamil preeklamsia dan ibu hamil tidak preeklamsiaDifferences of the salivary TNF-α level in pregnant women with and without preeclampsia Trisnawaty Trisnawaty; Eddy Mart Salim; Kemas Yakub
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 29, No 3 (2017): Desember
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.75 KB) | DOI: 10.24198/jkg.v29i3.15959

Abstract

Pendahuluan: Beberapa teori menyebutkan penyakit periodontal dapat meningkatkan faktor resiko preeklamsia. Gingivitis dapat menyebabkan peningkatan kadar TNF-α saliva dan dapat mengakibatkan inflamasi sistemik yang memicu terjadinya preeklamsia. Tujuan penelitian ini adalah untuk mengetahui perbedaan kadar TNF-α saliva dan derajat kesehatan gingiva pada ibu hamil preeklamsia dan ibu hamil tidak preeklamsia. Metode: Penelitian ini merupakan penelitian analitik korelatif. Populasi penelitian adalah ibu hamil yang datang ke Poli IGD dan Instalasi Rawat Inap Poli kebidanan RSMH Palembang. Teknik pengambilan sampel Consecutive Sampling dengan minimal sampel berjumlah 30 pasien. Sampel yang diperoleh 38 pasien yang terdiri dari 19 pasien ibu hamil preeklamsia dan 19 pasien ibu hamil tidak preeklamsia. Masing-masing disebut sebagai kelompok kasus dan kontrol. Sampel diambil berdasarkan kriteria eksklusi dan inklusi pada ibu hamil dengan skor indeks gingiva 3, kemudian dilakukan uji ELISA. Analisis statistik dengan uji parametrik Independent T-test. Hasil: Nilai kadar TNF-α saliva kelompok kasus 143,27±87,20 pg/ml dan kelompok kontrol 142,46±44,76 pg/ml, p=0.972. Simpulan: Tidak terdapat perbedaan bermakna antara nilai kadar TNF-α saliva ibu hamil preeklamsia dan ibu hamil tidak preeklamsia.Kata kunci: Preeklamsia, indeks gingiva, kadar TNF-α saliva. ABSTRACTIntroduction: Some theories suggest that periodontal disease can increase the risk factors for preeclampsia. Gingivitis can cause an increase in salivary TNF-α levels and can result in systemic inflammation that triggers preeclampsia. The purpose of this study was to determine differences of the salivary TNF-α level and the gingival health degree in pregnant women with and without preeclampsia. Methods: This study was correlative analytic. The study population was pregnant women who came to the emergency room unit and the obstetric inpatient clinic of Dr Mohammad Hoesin Hospital Palembang. The sampling technique was consecutive sampling with a minimum sample of 30 patients. The sample obtained was as much as 38 patients consisted of 19 pregnant women with preeclampsia and 19 pregnant women without preeclampsia. Each group was referred to as a case and control group. Samples were taken based on the exclusion and inclusion criteria in pregnant women with the gingival index score of 3; then an ELISA test was performed. Statistical analysis with independent t-test parametric test was performed to analyse all data obtained. Result: The value of salivary TNF-α in the case group was 143.27 ± 87.20 pg/ml, and the control group was 142.46 ± 44.76 pg/ml; p = 0.972. Conclusion: There was no significant difference between the values of salivary TNF-α level in pregnant women with and without preeclampsia.Keywords: Preeclampsia, gingival index, salivary TNF- α level.
Correlation of heart failure severity and N-terminal pro-brain natriuretic peptide level in children Yasmien Mahrani; Ria Nova; Masagus Irsan Saleh; Kemas Yakub Rahadianto
Paediatrica Indonesiana Vol 56 No 6 (2016): November 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.152 KB) | DOI: 10.14238/pi56.6.2016.315-9

Abstract

Background  Heart failure affects morbidity and mortality in children with heart disease. There is no single, specific test to diagnose heart failure. The modified Ross Reithmann scoring system has been used to classify heart failure severity, but it is limited due to its subjectivity. The N-terminal pro-brain natriuretic peptide (NT-proBNP) is secreted by the ventricles during heart failure. It has been suggested as a possible marker for diagnosing heart failure.Objective To investigate the correlation between heart failure severity and plasma NT-proBNP concentration in children aged one month to 14 years.Methods A cross-sectional study was performed in the Pediatrics Department of Mohammad Hoesin Hospital from July to September 2015 on children with congestive heart failure, aged one month to 14 years. Heart failure severity was assesed using the modified Ross Reithmann scoring system. Plasma NT-proBNP measurements were done in all subjects. Statistical analysis was done by Spearman’s test.Results  Subjects’ median plasma NT-proBNP concentration was 1,703 pg/mL (range 310-9,000 pg/mL). The NT-proBNP level and severity of heart failure had a significant, positive correlation (r=0.87; P<0.001). The NT-proBNP minimum levels in subjects with mild, moderate and severe heart failure were 310 pg/mL, 1,251 pg/mL, and 2,610 pg/mL, respectively.Conclusion Plasma NT-proBNP level has a significant, positive correlation with the severity of heart failure in children. As such, NT-proBNP level may be useful as a biochemical marker for the diagnosis and grading of the severity of heart failure in children.
Co-Authors Agustin, Berliana Eddy Mart Salim Larasati, Veny Masagus Irsan Saleh Phey Liana Ria Nova Trisnawaty Trisnawaty Yasmien Mahrani