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All Journal The New Ropanasuri Journal of Surgery Jurnal Ilmu Bedah Indonesia Narra J Jurnal Locus Penelitian dan Pengabdian The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Journal of Global Pharma Technology Journal of English Education
Dedy Pratama
Division Of Vascular And Endovascular Surgery‎, Departement Of Surgery, Faculty Of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo General National Hospital, Jakarta
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health

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Journal : Journal of Global Pharma Technology

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Single Nuclear Polymorphisms of VEGF, TGF-β1, MMP9 Genes in Type 2 Diabetic Foot Ulcer Patients in Indonesian Population: A Case Control Study Dedy Pratama
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Vascular endothelial growth factor (VEGF), transforming growth factor beta 1 (TGF-β1) and matrix metalloprotein-9 (MMP9) are known to have roles in the process of diabetic foot ulcer (DFU) formation. VEGF rs2010963C>G rs1271283232T>C, TGF-β1 rs1982073C>T rs1800469C>T, and MMP9 rs3918242C>T rs367601348A>G genes polymorphism may result in differences in the quantity and quality of the proteins which influence the risk of DFU formation. This study aims to assess the difference in frequency distribution of certain VEGF, TGF-β1, and MMP9 genes polymorphism between diabetic patients with and without DFU.Methods: A case-control study was conducted among patients with type-2 DM with DFU (case) and without DFU (control) in Cipto Mangunkusumo Hospital Jakarta, with DNA analysis using Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP) technique. The confounding factors are also analyzed.Results: A total of 197 patients was assessed, 96 with DFU and 101 control. The genotype analysis by logistic regression found significant association of CT genotype in TGF-β1 rs1982073C>T  (OR:0.28;95%CI:0.13-0.60;p=0.001 compared with CC); TT genotype in TGF-β1 rs1800469C>T, (OR:2.37;95%CI:1.11-0.60;p=0.001 compared with CC); TC genotype in MMP9 rs3918242C>T (OR:0.19;95%CI:0.19-0.64;p=0.001 compared with CC). There are no significant association in any mutation in VEGF rs2010963C>G, rs1271283232T>C, and MMP9 rs367601348A>G.Conclusion: VEGF rs2010963C>G rs1271283232T>C, and MMP9 rs367601348A>G polymorphisms did not have significant association with DFU formation. CT in TGF-β1 rs1982073C>T and TC in MMP9 rs3918242C>T found as protective factor for DFU, and TT in TGF-β1 rs1800469C>T as risk factor for DFU.Keywords: diabetic foot ulcer, genetic polymorphism, VEGF, MMP9, TGF-β1, rs2010963C>G, rs1271283232T>C, rs1982073C>T, rs1800469C>T, rs3918242C>T rs367601348A>G
Co-Authors Alfa Firdaus Almidawati Anindya P. Susanto Bermana, Frengky Candra Irawan Charles Krisnanda Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Darwis, Patrianef Dhanasari Vidiawati Doreen S-Y. Tan Fachriza, Ihza Grace Wangge, Grace Harisandi, Sandra Harunarashid, Hanafiah Hean-Ye Ong Hudaya, Miradz I Gusti Agung Bagus Krisna Wibawa Irfan, Witra Karina Zulkarnain Lesmana, Andy Muradi, Akhmadu Patrianef Darwis Purnomo, Hari Agus Rasjid Soeparwata Rudi Hermansyah, Rudi Sinaga, Bunga Riama Suhartono, Raden Teguh Dwi Nugroho Yang, Andrew Jackson