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All Journal Paediatrica Indonesiana Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indonesian Journal of Cancer
Lyana Setiawan
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Free testosterone level in patients with homozygous beta thalassemia on regular transfusions regimen Riadi Wirawan; Elly Santosa; Lyana Setiawan; Bulan Ginting Munthe; Dalima AW Astrawinata
Paediatrica Indonesiana Vol 44 No 2 (2004): March 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.514 KB) | DOI: 10.14238/pi44.2.2004.73-9

Abstract

Background Patients with homozygous beta thalassemia requireregular transfusions which will lead to iron deposition in tissuesincluding testicles.Objective This study aimed to evaluate testicular function in syn-thesizing testosterone by measuring free testosterone level. Thecorrelation between free testosterone level and transferrin satura-tion was evaluated.Methods This was a cross sectional study. Sampling was doneconsecutively. Free testosterone level was measured by radioim-munoassay in 20 homozygous beta thalassemic patients receiv-ing regular transfusions and compared to 20 healthy subjects.Results Fourteen out of 20 patients showed free testosterone levelbelow the reference range. Out of 20 thalassemic patients, onepatient’s serum was not enough for transferrin saturation determi-nation. Among the 19 patients, 18 had transferrin saturation above55%, 1 less than 55%, while all healthy subjects had normal trans-ferrin saturation. A significant difference was found between thetwo groups, both in the free testosterone level (p=0.001) and trans-ferrin saturation (p<0.001). A very weak correlation was found be-tween free testosterone level and transferrin saturation (r=-0.215).Conclusion We concluded that there might be a relationship be-tween iron overload and testicular endocrine function in patientswith homozygous beta thalassemia receiving regular transfusions
CASPASE-3 AKTIF DI LEUKEMIA MIELOSITIK AKUT (LMA) DAN LEUKEMIA LIMFOBLASTIK AKUT (LLA) Agus Setiawan; Indarini Indarini; Lyana Setiawan; Siti Boedina Kresno; Nugroho Prayogo; Arini Setiawati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 3 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i3.411

Abstract

Dysregulation of apoptosis plays an essential role either in leukemogenesis or treatment response. Caspase-3 is a cysteine protease that functions as the final common mediator of apoptosis. The expression of the active caspase-3 is presumed as a predictor of prognosis and is able to predict the chemotherapy sensitivity. The aim of this study is to identify and to know the profile of active caspase-3 in Acute Myeloid Leukaemia (AML) and Acute Lymphoblastic Leukaemia (ALL), to correlate its expression in marrow and peripheral blood mononuclear cells, and to verify the extent of its use as a complete remission predictor after induction treatment. The study subjects consisted of patients who were diagnosed as AML and ALL with marrow and peripheral blood examination performed at the Department of Clinical Pathology Dharmais Cancer Hospital and CiptoMangunkusumo Hospital. Based on this study, it is revealed that the active caspase-3 expression in mononuclear marrow cells was higher in AML compared to ALL (p=0.033), active caspase-3 expression in marrow showed a strong correlation (r=0.764; p=0.001) to peripheral blood mononuclear cells in ALL and a medium correlation (r=0.594; p=0.042) in AML. The expression of the active caspase-3 in ALL patients was lower in complete remission patients compared to the non-complete remission patients. Regarding to this study it is recommended to measure the active caspase-3 along with molecules integrating in apoptosis signaling pathways such as cytochrome-c and in the formation of apoptosome.
Immunophenotyping in the Diagnosis and Classification of Acute Leukemia: "Dharmais" Cancer Hospital Experience Agus Susanto Kosasih; Lyana Setiawan; Sri Hartini
Indonesian Journal of Cancer Vol 5, No 1 (2011): Jan - Mar 2011
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (74.918 KB) | DOI: 10.33371/ijoc.v5i1.84

Abstract

Penentuan imunofenotipe merupakan salah satu pemeriksaan yang disyaratkan dalam diagnosis dan klasifikasi leukemia. Dalam tulisan ini, kami melaporkan data peranan penentuan imunofenotipe dalam diagnosis leukemia akut dikaitkan dengan pemeriksaan sitomorfologi dan pemeriksaan sitokimia Sudan Black B (SBB) yang dilakukan di Laboratorium Patologi Klinik Rumah Sakit Kanker Dharmais (RSKD) sejak Januari 2005 sampai Desember 2007.Menurut imunofenotipe, kami menemukan 13 kasus leukemia limfoblastik akut (LLA) galur T, 82 kasus LLA galur B, dan 110 kasus leukemia mieloblastik akut (LMA). Ko-ekspresi antigen dari galur lain ditemukan pada 38% kasus LLA-T, 28% kasus LLA-B, dan 37% LMA. Antigen limfoid yang paling sering ditemukan ekspresinya pada LMA adalah CD19 diikuti CD7.CD33 ditemukan pada 94,6% kasus LMA dan CD13 pada 87,8% kasus LMA. CD19 ditemukan pada 96% LLA-B, CD10 pada 68% kasus, diikuti CD20 (50%) dan CD22 (33%). CD7 ditemukan pada 92% LLA-T, dan CD3 positif pada 85% kasus LLA-T.Disimpulkan bahwa penentuan imunofenotipe sangat bermanfaat dalam penentuan diagnosis galur, membedakan antara LLA dan LMA, khususnya pada kasus dengan SBB negatif seperti pada kasus LMA-M0 dan M5a, membedakan LLA-B dan LLA-T, serta mendiagnosis kasus leukemia bifenotipe/leukemia galur campuran.Kata kunci: Leukemia akut, imunofenotipe, galur myeloid, LLA-B, LLA-T.
Co-Authors Agus Susanto Kosasih Arini Setiawati Bulan Ginting Munthe Dalima AW Astrawinata Elly Santosa Indarini Indarini Laksono Trisnantoro Nugroho Prayogo Riadi Wirawan Siti Boedina Kresno Sri Hartini