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Arwin P. Akib
Department of Child Health, University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, Jakarta
Health Professions Medicine & Pharmacology

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Clinical and laboratory features of typhoid fever in childhood Sylvia Retnosari; Alan R. Tumbelaka; Arwin P. Akib; Sri Rezeki Hadinegoro
Paediatrica Indonesiana Vol 41 No 5-6 (2001): May 2001
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (137.445 KB) | DOI: 10.14238/pi41.3.2001.149-54

Abstract

The aims of the study were to review the clinical features of patient with suspected typhoid fever, to obtain features of the blood culture results, Widal, Typhidot tests and to identify the relationship between/prior antibiotic administration with laboratory findings. The study had been conducted since January 1, 1999 till January 31, 2000 with inclusion criteria (1) age of patient was 3 to 14 years, (2) patient with diagnosis of suspected typhoid fever and (3) gave consent to participate in the present study. Thirty-six patients were eligible for this study and the result showed that typhoid fever was encountered more commonly in girls with the most prevalent onset was in age 5 to 9 years and duration of fever was less than 8 days. Gastrointestinal tract disturbance was the most frequent complain after fever. Most patient showed negative results in blood culture examination and Widal test, and gave positive results in Typhidot/Typhidot M test as well. Antibiotic administration tended to influence blood culture and Widal test as to need consideration in evaluation of laboratory results. However, a conclusion still could not be drawn definitively that further study with adequate sample number and positive blood culture as criteria inclusion was needed. 
Clinical Features and Liver Biochemical Activity of Hepatitis A S. Zuraida Zulkarnain; Anna Tjandarjani; Arwin P. Akib
Paediatrica Indonesiana Vol 39 No 11-12 (1999): November - December 1999
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.241 KB) | DOI: 10.14238/pi39.11-12.1999.302-7

Abstract

A descriptive, cross sectional study, was conducted between January 1st 1993 until June 30th 1998. The objective of the study is to describe clinical features and liver biochemical activity of hepatitis A. Ninety three cases of hepatitis A (55,0%) were colleed from hospitalized acute viral hepatitis. Only 92 cases were evaluated, becuse no initial data was found in one case. The highest number of cases (44.5%) was in the age group of 5-10 years, 53 cases (57.6%) were boys and 39 cases (42.4%) were girls. From the history of illness 82 cases (89: 1 %) with jaundice, 60-80% with fever, nausea, vomiting, and anorexia. Abdominal pain and weakness in 35%, less than 12% wlth headache, myalgia, diarrhea, common cold and cough. Fifty cases (54.3%) were underweight based on weight for age. From physical examination 89.1% of cases showed Jaundice, 68.5% hepatomegaly, 23.9% abdominal tenderness, 18.5% fever, 6.5% splenomegaly, 5% pale, and 1.1% unconscious. Test of biochemical activity showed wide range result, AST 22-2869 IU/L, ALT 22-2880 IU/L, conjugated bilirubin 0.07-20.27 mg/dL and unconjugated bilirubin 0.14-11.89 mg/dL. Prolonged cholestatic, fulminant hepatitis and anerma were found in less than 3.2% of cases.
Co-Authors Alan R. Tumbelaka Anna Tjandarjani S. Zuraida Zulkarnain Sri Rezeki Hadinegoro Sylvia Retnosari