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Hendra Santoso
Department of Child Health, Udayana University Medical School/Sanglah Hospital, Denpasar, Bali
Health Professions Medicine & Pharmacology

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Autoimmune hemolytic anemia warm-antibody type (Warm AIHA) in an 8-year-old Balinese girl Putu Tri Yasa; Ida Bagus Mudita; Hendra Santoso; Sudaryat Suraatmadja
Paediatrica Indonesiana Vol 41 No 1-2 (2001): January 2001
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.704 KB) | DOI: 10.14238/pi41.1.2001.64-8

Abstract

A case of autoimmune hemolytic anemia warm antibody type A (warm AIHA) in an 8-year-old Balinese girl was reported. The diagnosis was established based on clinical features, laboratory findings including positive Coombs'  test positive. The etiology was probably primary or Idiopathic. The child was transfused with packed red cells and treated with oral prednisone. The response of the treatment was good and she experienced complete remission. The prognosis in patients with idiopathic warm AIHA are unpredictable. The girl underwent further follow-up in the child hematologic division every two weeks.
Liver function in children with human immunodeficiency virus infection before and after 6 months of highly active antiretroviral therapy Eva Jacomina Jemima Sapulete; I Gusti Ngurah Sanjaya Putra; Ketut Dewi Kumara Wati; Hendra Santoso; I Putu Gede Karyana; Komang Ayu Witarini; Ni Nyoman Metriani Nesa
Paediatrica Indonesiana Vol 58 No 4 (2018): July 2018
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (241.154 KB) | DOI: 10.14238/pi58.4.2018.159-64

Abstract

Background Highly active antiretroviral therapy (HAART) has resulted in dramatic decreases in morbidity and improved survival rate in human immunodeficiency virus (HIV)-infected patients. Although the risk of morbidity has decreased, it has been replaced by other long-term complications, such as hepatotoxicity. Hepatotoxicity is often reflected in biochemical abnormalities of liver function, such as elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and aspartate aminotransferase-to-platelet ratio index (APRI). Objective To compare liver function spectrum (AST, ALT, and APRI) in HIV-infected children before and after at least 6 months of HAART. Methods This observational study (before and after) was conducted in pediatric patients with HIV infection who received HAART for at least 6 months at Sanglah Hospital, Denpasar. Data were collected from medical records. Results Forty-nine patients were observed in this study. The mean AST, ALT, and APRI levels before HAART were higher than after at least 6 months of HAART. Anti-tuberculosis treatment and fluconazole therapy were not confounding factors for AST, ALT, and APRI. Conclusion Liver function spectrum enzyme levels of AST, ALT, and APRI are improved after at least 6 months of HAART.
Co-Authors Eva Jacomina Jemima Sapulete I Gusti Ngurah Sanjaya Putra I Putu Gede Karyana Ida Bagus Mudita Ketut Dewi Kumara Wati Komang Ayu Witarini Ni Nyoman Metriani Nesa Putu Tri Yasa Sudaryat Suraatmadja