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All Journal Berkala Ilmiah Mahasiswa Farmasi Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Feliadewi Ruth
Universitas Ma Chung
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Reaksi Obat yang Tidak Dikehendaki (Rotd) pada Pasien Rawat Jalan Penyakit Ginjal Kronis Tahap Akhir di Komunitas Pasien Cuci Darah Indonesia Cabang Jawa Timur : Metode Cross Feliadewi Ruth; Martanty Aditya; Muhammad Hilmi Aftoni
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 1 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i1.60

Abstract

Introduction: Adverse Drug Reaction (ADR) is a side effect arising from the use of drugs with normal doses. ADR might decrease quality of life, increase frequency to doctor, and death. ADR in patients with End-Stage Renal Disease (ESRD) has not been much studied. ESRD have a greater risk of experiencing ADR because the kidneys have decreased and the drugs can accumulate in the body. Study was conducted to determine the incidence of ADR in outpatients in the final stage of ESRD. Methods: This study use cross sectional method. Demographic data and ADR status were collected from members of the Indonesian Dialysis Patient Community in East Java. Drug data had grouped into drugs that potential and no potential for ADR, then an analysis with a Chi-square test to find correlation of potential ROTD drugs and the incidence of ADR in outpatients in ESRD. Result: There are 62 respondents in this study who fulfilled the inclusion. From the test between the characteristic and ADR is a correlation between allergies and ADR (p = 0.018). Based on the results of the Chi-square test between the use of potential ADR drugs with the incidence of ADR in outpatients in the final stage of the patient did not have a correlation (p value = 0.812). Conclusion: From this study it can be concluded that there is no correlation between potential ROTD drugs with the incidence of ROTD in end-stage CKD outpatients (p = 0.812).
Peran Lipid Nanoparticles dalam Teknologi Vaksin mRNA: Peluang dan Hambatan feliadewi ruth
Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas Vol. 3 No. 2 (2025): Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas
Publisher : Program Studi Farmasi, Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jfmc.v3i2.100

Abstract

Lipid nanoparticles (LNP) constitute critical delivery systems for both vaccine formulations and mRNA-based therapeutic strategies; nevertheless, concerns regarding their efficacy, safety, and design optimization continue to be prevalent. This review is designed to systematically evaluate the function of LNP within the framework of mRNA vaccine technologies, emphasizing mechanistic insights, stability assessments, safety considerations, and challenges in manufacturing. Comprehensive literature reviews were conducted utilizing databases such as PubMed, ScienceDirect, and Semantic Scholar for peer-reviewed articles published between the years 2020 and 2025, with the application of relevant keywords. From the 418 articles identified, 57 met the inclusion criteria following rigorous screening and were subjected to thematic analysis based on parameters including efficacy, safety, stability, and optimization strategies. The results reveal that LNP substantially enhances mRNA stability and expression in vivo, fortifies robust immune responses, and serves a vital role in the effective deployment of various mRNA vaccines, particularly those aimed at combating infectious diseases. However, challenges such as sensitive stability, insufficient endosomal escape, hepatic accumulation, toxicity concerns, and complex manufacturing processes remain significant issues of concern. It is concluded that while current formulations of LNP exhibit effectiveness for specific applications, they are not universally optimal; consequently, further advancements in design, targeting, and production methodologies are imperative to improving the efficacy, safety, and accessibility of LNP-based mRNA vaccines.
Co-Authors Martanty Aditya, Martanty Muhammad Hilmi Afthoni