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All Journal Jurnal Ilmiah Farmasi Natural Science: Journal of Science and Technology Pharmaciana: Jurnal Kefarmasian DeKaVe The Journal of Pure and Applied Chemistry Research Jurnal Farmasi Klinik Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Scholaria: Jurnal Pendidikan dan Kebudayaan Jurnal Wiyata : Penelitian Sains dan Kesehatan CARADDE: Jurnal Pengabdian Kepada Masyarakat Academia Open Berkala Ilmiah Mahasiswa Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Community Practice and Social Welfare (JaCiPS) Media Farmasi Indonesia Sainsbertek Jurnal Ilmiah Sains & Teknologi Prosiding Seminar Nasional Universitas Ma Chung Jurnal Novem Medika Farmasi Jurnal Farmasi Ma Chung: Sains, Teknologi, dan Klinis Komunitas KOPEMAS
Martanty Aditya, Martanty
Program Studi Farmasi Fakultas Sains Dan Teknologi Universitas Ma Chung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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REVIEW KORTIKOSTEROID INDUKSI SINDROM PSIKOTIK Aditya, Martanty
Jurnal Wiyata Penelitian Sains dan Kesehatan Vol 3, No 1 (2016)
Publisher : LP2M IIK (Lembaga Penelitian dan Pengabdian Masyarakat Institut Ilmu Kesehatan) Bhakti Wiy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (293.533 KB)

Abstract

Latar belakang: Indikasi penggunaan kortikosteroid semakin meningkat, diikuti pula dengan efek samping yang semakin banyak. Salah satunya adalah steroid psikotik. Tujuan: Mereview potensi kortikosteroid dalam menginduksi terjadinya psikotik. Metode: Penelusuran menggunakan mesin pencari dengan melihat kesesuaian dan relevansi dari 5 laporan kasus, 7 review, 10 systematic review dan 3 meta analysis dengan sumber artikel, tahun penerbitan dan asal dari sumber artikel. Hasil: Efek psikotik kortkosteroid pada beberapa penelitian tidak dapat digeneralisasikan karena variasi jumlah dosis dan lama waktu pemberian sehingga tidak dapat memprediksi kejadian steroid induksi psikosis. Selain itu juga penggunaan steroid dihubungkan dengan data subyektif misalnya riwayat penyakit, usia dan jenis kelamin ataupun dari rute pemberian sediaan kortikosteroid. Penggunaan kortikosteroid jangka panjang pada kondisi tertentu juga dapat menurunkan angka mortalitas. Berdasarkan review artikel ini juga diketahui bahwa penggunaan kortikosteroid sebagai terapi tambahan pada flu dan pilek tidak dapat dibuktikan efektivitasnya. Simpulan dan saran: Belum didapatkan bukti yang cukup untuk mengidentifikasi efek samping kortikosteroid induksi psikotik sehingga diperlukan systematic review dengan mengurangi bias hasil review.
Penelusuran aktivitas antibakteri, antioksidan, dan sitotoksik fungi endofit genus fusarium sp. diisolasi dari daun meniran (Phyllantus niruri Linn.) rollando, Rollando; Aditya, Martanty; Notario, Dion; Monica, Eva; Sitepu, Rehmadanta
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.762 KB) | DOI: 10.12928/pharmaciana.v7i1.5644

Abstract

Endophytic fungi used as a new resource to produce bioactive compounds such as antibacterial, antioxidant and anticancer. This study aimed to analyze the antibacterial, antioxidant, cytotoxic fraction of the separation ethyl acetate extract of mycelium of endophytic fungi genus Fusarium sp. Diethyl ether fraction showed high antibacterial activity in E.coli (20,75 µg/mL), S.typhi (35,08 µg/mL), and S.aureus (51,96 µg/mL). Test showed that the antioxidant activity of ethanol 96% fraction has highest antioxidant activity and total phenolic content (75,85 ± 0.87 mg GAE). Cytotoxic test on T47D breast cancer cells showed that the fraction of diethyl ether have highest activity with IC50 of 10,16 ± 0,88 µg /mL.
ANALISIS FAKTOR PERLINDUNGAN MATAHARI (FPM) DARI SEDIAAN TABIR SURYA SECARA SPEKTROFOTOMETRI DENGAN METODE KUADRAT TERKECIL SEBAGIAN JACK-KNIFE Notario, Dion; Aditya, Martanty; Rollando, Rollando; Prilianti, Kestrilia Rega
Natural Science: Journal of Science and Technology Vol 6, No 1 (2017): Volume 6 Number 1 (March 2017)
Publisher : Univ. Tadulako

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Abstract

Penentuan nilai Faktor Perlindungan Matahari (FPM) dengan metode spektrofotometri sangat dibutuhkan untuk melakukan penapisan awal kandidat bahan aktif tabir surya. Meskipun demikian, ditemukan kesalahan yang relatif besar ketika dilakukan penentuan SPF secara spektrofotometrik terhadap beberapa sediaan tabir surya yang beredar secara komersial. Oleh karena itu, dalam penelitian ini dilakukan analisis FPM secara spektrofotometrik pada panjang gelombang 290 ? 320 nm yang dilanjutkan dengan regresi multivariat yaitu kuadrat terkecil sebagian jack-knife untuk meningkatkan akurasi estimasi nilai prediksi FPM secara in vitro. Selanjutnya, model matematik yang diperoleh, digunakan untuk melakukan penapisan bahan aktif tabir surya dari beberapa sampel botani. Hasil penelitian menunjukkan bahwa model matematik yang dihasilkan mempunyai nilai kesalahan prediksi yang lebih rendah daripada metode sebelumnya (RMSECV = 3,15; r = 0,915) dan dapat diaplikasikan untuk penapisan kandidat bahan aktif tabir surya dari tanaman.
Optimalisasi Pesan Dalam Buku Edukasi Pasien Diabetes Melitus Melalui Komunikasi Visual Tegar Andito; Martanty Aditya
DeKaVe Vol 12, No 2 (2019): Jurnal DeKaVe Vol. 12 No. 2 2019
Publisher : Institut Seni Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.627 KB) | DOI: 10.24821/dkv.v12i2.3522

Abstract

The risk of Angiotensin Converting Enzyme Inhibitor (ACEI) and Calcium Channel Blocker (CCB) used on Obstructive Sleep Apnea (OSA) incidence in hypertension patients Fibe Yulinda Cesa; Martanty Aditya; Rehmadanta Sitepu; Dion Notario
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art1

Abstract

AbstractBackground: The administration of angiotensin-converting enzyme inhibitor (ACEI) and calcium channel blocker (CCB) therapy is known to have a side effect of a dry cough that would trigger OSA. Further research is needed to compare the effect of these two drugs on the side effects of OSA, which could trigger high-risk patient conditions.       Objective: To determine the risk of using ACE and CCB on the incidence of OSA using a case-control study method at Dau Primary Health Center.Methods: Demographic data were collected on 207 respondents aged 40-60 years by collecting Data Collection Sheets and Berlin questionnaires to determine the risk of OSA in respondents. Then, statistical analysis was carried out by determining the odds ratio (OR).Results: The results showed that one of the factors BMI (obese BMI; OR=1.33; 95% CI=0.11-15.70) induces OSA with the highest OR value compared to other factors.Conclusion: Obese patient has a 1.33 times greater risk of OSA with ACEI and CCB therapy than non-obese. It is necessary to conduct further research with a larger sample size related to OSA’s assessment associated with this therapy to improve patients’ quality of life.Keywords: Obstructive sleep apnea, ACE inhibitors, calcium channel blockers, hypertension IntisariLatar belakang: Obtructive Sleep Apnea (OSA) yang terjadi pada pasien hipertensi dapat disebabkan karena efek samping dari penggunaan antihipertensi angiotensin converting enzyme inhibitor (ACEI) dan calcium channel blocker (CCB), namun analisis hubungan keduanya belum diketahui dengan pasti.Tujuan: Penelitian ini bertujuan untuk mengetahui risiko penggunaan ACE dan CCB terhadap kejadian OSA dengan metode case control study di Puskesmas Dau.Metode: Pengambilan data demografi pada 207 responden usia 40-60 tahun dilakukan dengan mengumpulkan Lembar Pengumpul Data (LPD) dan kuesioner Berlin untuk mengetahui risiko OSA pada responden kemudian dilakukan analisis statistik dengan penentuan odds ratio (OR).Hasil: Hasil penelitian menunjukkan bahwa pasien yang menjalani pengobatan dengan antihipertensi ACEI dan obesitas memiliki risiko lebih besar mengalami OSA (OR=1,33; CI 95%=0,11-15,70)  yaitu 1,33 kali dibandingkan pada pasien yang tidak obesitas.Kesimpulan: Obesitas menjadi factor risiko terhadap kejadian OSA pada pasien hipertensi yang mendapatkan antihipertensi golongan ACEI dan CCB.Kata kunci: Obstructive sleep apnea, ACE inhibitor, calcium channel blocker, hipertensi
Antimicrobial, antioxidant, and cytotoxic activities of endhopitic fungi Chaetomium sp. isolated from Phyllanthus niruri Linn: in vitro and in silico studies Rollando Rollando; Dion Notario; Eva Monica; Martanty Aditya; Rehmadanta Sitepu
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1433.715 KB) | DOI: 10.21776/ub.jpacr.2017.006.01.317

Abstract

Endophytic fungi Chaetomium sp isolated from Phyllanthus niruri Linn. Mycelium powder was extracted by using ethyl acetate. Extract was fractionated using n-hexane, dichloromethane and ethanol 96%. The antimicrobial test was carried out using disc diffusion and microdilution methods. The antioxidant activity of the fraction was determined using hydrogen peroxide free radical scavenging and reducing power capacity activities. The cytotoxicity assay of the fraction against T47D breast cancer cell was carried out using dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide method (MTT). The in silico prediction of chemical substances which are reported exist in Chaetomium sp. performed using AutoDockVina embedded in PyRx version 8.0. Dichloromethane fraction was found as the most active sample against Escherichia coli (IC50 20.76 mg/mL), Staphylococcus aureus (IC50 70.15 mg/mL), Salmonella typhi (49.13 mg/mL) and was found as the most high phenolic content with value 47.44 mg GAE/g fraction, whereas the best antioxidant activity was performed by ethanol 96% fraction (85%). Cytotoxicity assay against T47D cell line showed dichloromethane fraction have highest activity with IC50 10.76 mg/mL. The docking studies showed that compounds bearing xanthone structure were potential for maltose binding periplasmic and human aromatase associating with their potencies as antibacteria and anticancer. Endophytic fungi Chaetomium sp. was isolated from Phyllanthus niruri using n-hexane, dichloromethane and ethanol fractions was studied its various biological activities as antimicrobial, antioxidant and cytotoxic agent against breast cancer cell. 
Pengukuran Risiko Gangguan Tidur pada Penggunaan Angiotensin Converting Enzyme Inhibitor dan Calcium Channel Blocker: Case Control Study di Puskesmas Dau, Malang Martanty Aditya; Rehmadanta Sitepu; Dion Notario; Fibe Y. Cesa
Indonesian Journal of Clinical Pharmacy Vol 8, No 3 (2019)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (755.386 KB) | DOI: 10.15416/ijcp.2019.8.3.166

Abstract

Gangguan tidur atau insomnia yang muncul pada pasien hipertensi dapat disebabkan oleh efek samping obat-obat antara lain golongan Angiotensin Converting Enzyme Inhibitor (ACEI) dan Calcium Channel Blocker (CCB), namun besarnya pengaruh masing-masing golongan belum banyak diperbandingkan. Oleh karena itu, dilakukan penelitian dengan menggunakan rancangan case control untuk menilai risiko penggunaan ACEI dan CCB terhadap angka kejadian insomnia. Data demografi dan status insomnia dikumpulkan melalui Lembar Pengumpul Data (LPD) dan kuesioner Athens Insomnia Scale (AIS), kemudian dilakukan analisis univariat, bivariat, dan multivariat. Hasil analisis menunjukkan bahwa pada kelompok usia 56–60 tahun, pasien yang menjalani pengobatan dengan ACEI memiliki risiko insomnia lebih kecil yaitu sekitar 0,38 kali (p=0,026, 95% CI=0,15–0,94) dibandingkan dengan pasien lain yang menggunakan CCB, sedangkan pada kelompok kategorial yang lain tidak ditemukan hubungan yang signifikan. Dengan demikian, pemantauan efek samping insomnia menjadi penting untuk dilakukan oleh tenaga kesehatan terutama pada pasien yang menjalani pengobatan dengan CCB pada usia 56–60 tahun.Kata kunci: ACE inhibitor, calcium channel blocker, case control, gangguan tidur A Measurement of Sleep Disorder in the Use of Angiotensin Converting Enzyme Inhibitor and Calcium Channel Blocker: A Case Control Study at Dau Public Health Center, MalangAbstractSleep disorder or insomnia arisen in hypertensive patients might be derived as a side effect of antihypertensive mediations such as Angiotensin Converting Enzyme Inhibitor (ACEI) and Calcium Channel Blocker (CCB), but the influence of each group had not been much compared. Therefore, a research was conducted using case control design to assess the risk of using ACEI and CCB against the incidence rate of insomnia. Demographic data and insomnia status were collected through Data Collector Sheet and Athens Insomnia Scale (AIS) questionnaire before univariate, bivariate, and multivariate analysis was conducted. The result showed that in the age group of 56–60 years patients undergoing treatment with ACEI have a smaller risk of insomnia of approximately 0.38 times (p=0.026, 95% CI=0.15–0.94) compared to the other patients who were treated with CCB, while in other categorial groups, no significant relationship was found. Thus, the monitoring of insomnia side effects becomes important to be conducted by healthcare professional especially in patients undergoing treatment with CCB at the ages of 56–60 years.Keywords: ACE inhibitor, calcium channel blocker, case control, sleep disorder
Penelusuran aktivitas antibakteri, antioksidan, dan sitotoksik fungi endofit genus fusarium sp. diisolasi dari daun meniran (Phyllantus niruri Linn.) Rollando rollando; Martanty Aditya; Dion Notario; Eva Monica; Rehmadanta Sitepu
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.762 KB) | DOI: 10.12928/pharmaciana.v7i1.5644

Abstract

Endophytic fungi used as a new resource to produce bioactive compounds such as antibacterial, antioxidant and anticancer. This study aimed to analyze the antibacterial, antioxidant, cytotoxic fraction of the separation ethyl acetate extract of mycelium of endophytic fungi genus Fusarium sp. Diethyl ether fraction showed high antibacterial activity in E.coli (20,75 µg/mL), S.typhi (35,08 µg/mL), and S.aureus (51,96 µg/mL). Test showed that the antioxidant activity of ethanol 96% fraction has highest antioxidant activity and total phenolic content (75,85 ± 0.87 mg GAE). Cytotoxic test on T47D breast cancer cells showed that the fraction of diethyl ether have highest activity with IC50 of 10,16 ± 0,88 µg /mL.
Analysis of the Completeness of Procedures of Ventolin Inhaler Usage Through the Use of Video on Asthma Patients of Probolinggo Hospital Godeliva Adriani Hendra; Martanty Aditya; Chresiani Destianita Yoedistira
Journal of Community Practice and Social Welfare Vol. 1 No. 1 (2021): Journal of Community Practice and Social Welfare
Publisher : LPPM Universitas Ma Chung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33479/jacips.2021.1.1.23-32

Abstract

Asthma is an obstructive chronic pulmonary disease which causes shortness of breath and requires distinct diagnostic strategies and treatment management. The disease requires long-term treatment where the patient's condition can hopefully remain under control. There are still many symptom recurrences found in asthma patients due to inaccurate/incomplete procedures in using inhalers. The purpose of this community service is to develop knowledge and understanding of the completeness of usage procedures of Ventolin Inhalers by utilizing videos as visual training to achieve expected therapeutic effect and aid asthma patients in controlling/avoiding asthma relapse. Data collection was carried out through observation in the form of checklists which contained the procedures for using the inhaler, followed by descriptive analysis. The observations were made one month before and after video education. Education in video format was distributed on day one. The video was uploaded to Youtube and contain procedures on how to use the inhaler device. Alternatively, it can also be sent through the patient's WhatsApp account. The data collection process was carried out from April to July 2020. There were changes in the number of patients before and after the provision of video education. This shows the level of knowledge and understanding of asthma patients regarding the completeness of the procedure for using Ventolin Inhaler had increased. Inappropriate usage of inhalers or errors made during the implementation of each step can affect the effectiveness of drug therapy and can cause unwanted side effects.
Reaksi Obat yang Tidak Dikehendaki (Rotd) pada Pasien Rawat Jalan Penyakit Ginjal Kronis Tahap Akhir di Komunitas Pasien Cuci Darah Indonesia Cabang Jawa Timur : Metode Cross Feliadewi Ruth; Martanty Aditya; Muhammad Hilmi Aftoni
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol 8 No 1 (2021): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v8i1.60

Abstract

Introduction: Adverse Drug Reaction (ADR) is a side effect arising from the use of drugs with normal doses. ADR might decrease quality of life, increase frequency to doctor, and death. ADR in patients with End-Stage Renal Disease (ESRD) has not been much studied. ESRD have a greater risk of experiencing ADR because the kidneys have decreased and the drugs can accumulate in the body. Study was conducted to determine the incidence of ADR in outpatients in the final stage of ESRD. Methods: This study use cross sectional method. Demographic data and ADR status were collected from members of the Indonesian Dialysis Patient Community in East Java. Drug data had grouped into drugs that potential and no potential for ADR, then an analysis with a Chi-square test to find correlation of potential ROTD drugs and the incidence of ADR in outpatients in ESRD. Result: There are 62 respondents in this study who fulfilled the inclusion. From the test between the characteristic and ADR is a correlation between allergies and ADR (p = 0.018). Based on the results of the Chi-square test between the use of potential ADR drugs with the incidence of ADR in outpatients in the final stage of the patient did not have a correlation (p value = 0.812). Conclusion: From this study it can be concluded that there is no correlation between potential ROTD drugs with the incidence of ROTD in end-stage CKD outpatients (p = 0.812).
Co-Authors Aftoni, Muhammad Hilmi agustin, Christina Aprilia, Devi Ratna Arif Santoso Cesa, Fibe Yulinda Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Chresiani Destianita Yoedistira Dewi Fortuna Surat Bala Dion Notario Dion Notario Ega Malia Jiska Eva Monica Eva Monica, Eva Feliadewi Ruth Feliadewi Ruth Fibe Y. Cesa Fibe Yulinda Cesa Fibe Yulinda Cesa Fibe Yulinda Cesa Fibe Yulinda Cesa Fina Noor Maghfira Godeliva Adriani Hendra Godeliva Adriani Hendra Haryanto Susanto Kestrilia Rega Prilianti Maitreya, Putera Monica, Eva Muhammad Hilmi Afthoni muliyawan, Johan Nurul Najlatun Nisa Putri Devy Septya Ratu, Modestus Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Renaldy Kristian Yohansyah ria septiana Rinda Puspita Sari Rollando, Rollando Sabrina Handayani Tambun Salsabila Rohadatul Aisy Sintia Dina Pranata Sitepu, Rehmadanta Sri Susilowati Sri Suwarni Sri Suwarni Suhul Raos Kumawula Ing Gustyas Tegar Andito Venty Yuliasari Wulandari, A. Ratna Yeni Rahmawati Yulis Mitra Reformasika