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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Perez Wahyu Purnasari
Fakultas Kedokteran Universitas Islam Sultan Agung (Unissula) Semarang, Jalan Jati I no. 146 Griya Pelutan Indah RT. 03, RW. 03 Pemalang Jawa Tengah
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PERBEDAAN EFEKTIVITAS SIMVASTATIN, EKSTRAK BAWANG PUTIH (ALLIUM SATIVUM), EKSTRAK BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) dan KOMBINASINYA TERHADAP KADAR LDL dan KOLESTEROL TOTAL (Studi Eksperimental Pada Tikus Jantan Dislipidemia) Yuniarifa, Conita; Djam'an, Qatrunnada; Purnasari, Perez Wahyu
Syifa'Medika Vol 11, No 2 (2021): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v11i2.2408

Abstract

Asupan kalori tinggi meningkatkan profil lipid yang menyebabkan dislipidemia. Tujuan penelitian ini adalah untuk mengetahui perbedaan efektivitas pemberian simvastatin, ekstrak bawang putih, ekstrak buah naga merah dan kombinasinya terhadap kadar LDL dan kolesterol total. Penelitian ini adalah eksperimental murni dengan desain pretest posttest control group pada 30 ekor tikus yang dibagi menjadi 6 kelompok secara acak. Lima kelompok diberikan diet tinggi kolesterol dan asam kolat sampai dislipidemia selama 14 hari dan satu kelompok tidak. Lima kelompok tikus dislipidemia mendapat perlakuan tertentu selama 14 hari. Semua kelompok diperiksa kadar LDL dan kolesterol total. Hasil uji Kruskal Wallismenunjukkan nilai p<0,05 artinya terdapat perbedaan penurunan kadar LDL yang signifikan di antara keenam kelompok. Hasil uji post hoc Mann Whitney menunjukkan bahwa kelompok P2 (ekstrak bawang putih 400 mg) memiliki efektivitas paling baik dalam menurunkan kadar LDL. Hasil uji Kruskal Wallis menunjukkan nilai p<0,05 artinya terdapat perbedaan penurunan kadar kolesterol total yang signifikan di antara keenam kelompok. Hasil uji post hoc Mann Whitney menunjukkan bahwa kelompok P1 (ekstrak buah naga merah 65 mg) dan P3 (ekstrak buah naga merah 32,5 mg dan bawang putih 200 mg) memiliki efektivitas paling baik dalam menurunkan kadar Kolesterol Total.
Pengaruh Lendir Bekicot (Achatina fulica) terhadap Jumlah Sel Fibroblas pada Penyembuhan Luka Sayat Studi Eksperimental pada Kulit Mencit (Mus musculus) Purnasari, Perez Wahyu; Fatmawati, Dina; Yusuf, Iwang
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (268.648 KB) | DOI: 10.30659/sainsmed.v4i2.376

Abstract

Background: Wound healing is very important to return skin as soon as possible and the integration is a complex and dynamic process. Proliferation phase involving fibroblasts is one of important step-on wound healing. Use of drugs such as povidone iodine on cuts aims to accelerate wound healing is still being debated. Healing by land snails’ mucus can be an alternative because it has many benefits. This study wants to know about the influence of land snails’ mucus on the number of fibroblasts in healing cuts.Design and methods: The study is an experimental research with post test only randomized control group design. The subjects were 18 Mus musculus strain mice that were divided into 3 groups. 1st group as a control group of untreated, 2nd group was given povidone iodine 10%, and 3rd group was given land snails’ mucus during 5th days. On the 6th day the mices were killed for histological study.Results: The data showed that average number of fibroblast in 1st group is 93,85; 2nd group is 126,37; and 3rd is group 217,5. The results of one way anova statistical test showed significant difference among the three groups p = 0,000. The results of post hoc test showed significant difference in all groups (p < 0,05).Conclusion: The mucus of land snail is influence the number of fibroblast in healing cuts (Sains Medika, 4(2):195-203).
Co-Authors Dina Fatmawati Djam'an, Qatrunnada Iwang Yusuf Yuniarifa, Conita