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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Amerta Nutrition Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Indonesian Journal of Global Health research
Yuniarifa, Conita
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Religion Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PERBEDAAN EFEKTIVITAS SIMVASTATIN, EKSTRAK BAWANG PUTIH (ALLIUM SATIVUM), EKSTRAK BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) dan KOMBINASINYA TERHADAP KADAR LDL dan KOLESTEROL TOTAL (Studi Eksperimental Pada Tikus Jantan Dislipidemia) Yuniarifa, Conita; Djam'an, Qatrunnada; Purnasari, Perez Wahyu
Syifa'Medika Vol 11, No 2 (2021): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v11i2.2408

Abstract

Asupan kalori tinggi meningkatkan profil lipid yang menyebabkan dislipidemia. Tujuan penelitian ini adalah untuk mengetahui perbedaan efektivitas pemberian simvastatin, ekstrak bawang putih, ekstrak buah naga merah dan kombinasinya terhadap kadar LDL dan kolesterol total. Penelitian ini adalah eksperimental murni dengan desain pretest posttest control group pada 30 ekor tikus yang dibagi menjadi 6 kelompok secara acak. Lima kelompok diberikan diet tinggi kolesterol dan asam kolat sampai dislipidemia selama 14 hari dan satu kelompok tidak. Lima kelompok tikus dislipidemia mendapat perlakuan tertentu selama 14 hari. Semua kelompok diperiksa kadar LDL dan kolesterol total. Hasil uji Kruskal Wallismenunjukkan nilai p<0,05 artinya terdapat perbedaan penurunan kadar LDL yang signifikan di antara keenam kelompok. Hasil uji post hoc Mann Whitney menunjukkan bahwa kelompok P2 (ekstrak bawang putih 400 mg) memiliki efektivitas paling baik dalam menurunkan kadar LDL. Hasil uji Kruskal Wallis menunjukkan nilai p<0,05 artinya terdapat perbedaan penurunan kadar kolesterol total yang signifikan di antara keenam kelompok. Hasil uji post hoc Mann Whitney menunjukkan bahwa kelompok P1 (ekstrak buah naga merah 65 mg) dan P3 (ekstrak buah naga merah 32,5 mg dan bawang putih 200 mg) memiliki efektivitas paling baik dalam menurunkan kadar Kolesterol Total.
Effect of Four Antioxidants Combination on Number of Sertoli and Leydig Cells, Sperm Quality and Caspase-3 Expression in Rat Exposed to Cigarette Smoke Yuniarifa, Conita; Wibowo, Joko Wahyu; Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 2 (2020): December 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1259.45 KB) | DOI: 10.30659/sainsmed.v11i2.2465

Abstract

Introduction: The administration of antioxidant combination has been shown to be more effective than that of individual antioxidant in male infertility.Objective: to determine the effect of different combination of antioxidants (vitamin/vit C, vit E, glutathione and zinc) on the number of Sertoli and Leydig cells, sperm quality and texpression of caspase-3 in rats exposed to cigarette smoke.Methods: This was an experimental study using a post test only control group design. Thirty six rats were randomly divided into 6 groups to receive one of the following combinations of antioxidants: vit C and E, glutathione, zinc (T4-G); vit C and E, glutathione (T3-G); vit C and vit E (T2-G); Glutathione, zinc (T1-G); control positive (CP-G) cigarette smoke exposed only, normal (CN-G). The dose of vit C, vit E, glutathion and zinc was 9 mg/day, 1.8 IU/day, 1.8 mg/day, 0.2 mg/day respectively. All groups were exposed to cigarette smoke (3 cigarettes/day for 21 days), except for the CN-G group. On day 22, sperm samples were taken. Testicular tissue was taken for measurements of sperm quality, sertoli and leydig cell.numbers.Results: There was a significant difference in mean number of Leydig cells, sperm motility, sperm count and caspase-3 between groups (p<0.05). Post hoc LSD showed that the administration of combination of four antioxidant agent increasing the number of Sertoli cells and sperm morphology. The results also showed that group treated with 4 antioxidants combination had the highest number of Leydig cells, sperm motility, sperm counts and the lowest expression of caspase-3.Conclusion:The combination of vitC, vit E, glutathione and zinc affects the number of Sertoli and Leydig cells, sperm quality, expression of caspase-3 in rats exposed to cigarette smoke .
Pengaruh Kombinasi Ekstrak Belimbing Wuluh (Averrhoa Bilimbi L.) dan Ekstrak Kunyit (Curcuma Longa L.) terhadap Kadar Low Density Lipoprotein: Effect of Combination of Averrhoa Bilimbi Extract and Curcuma Longa Extract on Low Density Lipoprotein Levels in Rats Fed a High Fat Diet Fatikhasari, Amalia Nurazima; Yuniarifa, Conita; Utami, Kamilia Dwi; Riza, Mohamad; Soetoko, Anita Soraya
Amerta Nutrition Vol. 8 No. 3 (2024): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i3.2024.363-367

Abstract

Background: Hypercholesterolemia is a state of total blood cholesterol levels transported by LDL exceeding normal limits. As a result, it can clog blood vessels, and this condition is a risk factor for CHD. Alternative medicine includes flavonoids in Averrhoa bilimbi (belimbing wuluh) known to reduce cholesterol and LDL levels, and curcumin in turmeric known to reduce fat absorption and increase fat excretion. Objectives: The aim of this study was to analyze the combined effect of bilimbi fruit and turmeric extracts on LDL levels. Methods: This experimental research used post-test only with a control group design involving male Wistar rats divided into 6 (six) random groups. Group KN (standard feed, aquadest for 28 days), K- (high-fat feed for 14 days, followed by standard feed and aquadest), K+ (high-fat feed for 14 days, followed by standard feed, aquadest, and simvastatin 0.18mg/200 g BW/day), P1 (high-fat feed for 14 days, followed by standard feed, aquadest and extracts of bilimbi fruit and turmeric extract at a dose of 240: 270 mg/200 g BW/day), P2 (high-fat diet for 14 days, followed by standard feed, distilled water and bilimbi fruit and turmeric extract at a dose of 360: 175 mg/200 g BW/day), P3 (high-fat diet for 14 days, followed by standard feed, distilled water and extracts of bilimbi fruit and turmeric at a dose of 120: 405 mg/200 g BW/day). The determination of LDL levels was done through a direct method using a spectrophotometer with a wavelength of 550 nm. Results: The mean LDL levels were KN (53.60 ± 10.69) mg/dL, K- (193.40 ± 16.86) mg/dL, K+ (100.20 ± 42.48) mg/dL, P1 (118.00 ± 64.71) mg/dL, P2 (104.00 ± 45.28) mg/dL, P3 (78.00 ± 4.69) mg/dL. The data received was analyzed using the Kruskal-Wallis test. Then, the results obtained differences in LDL levels between various groups (p<0.001). Subsequently, it was continued with the Mann-Whitney test on KN compared to K-, K+, P1, P2, P3 indicating p=0.009. As a result, it was found a significant difference in LDL levels between KN and K-, K+, P1, P2, and P3. Conclusions: This research concludes that providing a mixture of bilimbi fruit extract and turmeric extract can reduce LDL levels.
Pengaruh Kombinasi Probiotik, Ubi Jalar Ungu, dan Zinc terhadap Tebal Epitel Usus Mencit Jantan BALB/c Kolitis Ulseratif terinduksi Asam Asetat: Effect of Combination of Probiotics, Ipomoea Batatas, and Zinc on Thickness of Instestinal Epithelium in Mice Model of Acetic Acid-Induced Colitis Tsuraya, Ghefira; Yuniarifa, Conita; Hussaana, Atina; Riza, Mohamad; Masfiyah, Masfiyah
Amerta Nutrition Vol. 9 No. 2 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i2.2025.350-354

Abstract

Background: The use of probiotics to treat colitis is unsatisfactory, leading to a need for the combination with purple sweet potatoes (Ipomoea Batatas) and zinc. Objectives: This study aims to determine the effect of the combination of probiotics, purple sweet potatoes, and zinc on epithelial thickness.Methods: This was a post-test-only randomized controlled group experimental study using 30 mice divided into six groups, including KN, K-, K+, P1, P2, and P3. All groups except KN were induced with 4% acetic acid on day 1, then each received treatment for five days. KN, K+, P1, and P2 groups were given distilled water, sulfasalazine 1.3 mg/20 g BW, probiotics 0.078 mg/20 gBW + purple sweet potatoes 0.00169 g/20 gBW, and probiotics 0.078 mg/20 gBW + zinc 0.052 mg/20 gBW, respectively. Meanwhile, P3 received a combination of probiotics 0.078 mg/20 gBW + purple sweet potatoes 0.00169 g/20 gBW + zinc 0.0052 mg/20 gBW. Histological preparations were stained with Hematoxylin-Eosin and examined under 400× magnification across 10 fields of view. Results: The average epithelial thicknesses were KN (75.48±5.09), K− (28.02±5.60), K+ (69.1±13.82), P1 (47.05±9.41), P2 (48.6±9.73), and P3 (71.57±14.31). One-way analysis of variance (ANOVA) showed a significant difference among the groups with a p-value <0.001. Post Hoc LSD test identified significant differences (p-value<0.05) among all group pairs except between K+ and P3 (p-value=0.134) as well as P1 and P2 (p-value=0.349), but P3 had the highest average thickness value (71.57±14.31).Conclusions: The combination of probiotics, purple sweet potatoes, and zinc had an effect on intestinal epithelial thickness in male BALB/c mice with ulcerative colitis.
Factors that Influence Medication Compliance in Pulmonary Tuberculosis Patients Nugroho, Bayu M.A; Yuniarifa, Conita; Utami, Kamilia Dwi
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.5884

Abstract

Pulmonary tuberculosis is a chronic infectious disease that has a significant impact on global health, including Indonesia. Bandar I Health Center, Batang Regency was chosen as the research location because it has a low complete rate of taking medication (29.09%). Objective to analyze factors that influence medication compliance in pulmonary tuberculosis patients, including knowledge, attitudes, access to health services, drug side effects, family support, and support from health workers. An analytical observational design with a cross-sectional method. Data were collected through questionnaires from 68 pulmonary tuberculosis patients who met the inclusion criteria. Bivariate analysis used the Chi-Square test to determine the relationship between each independent variable and compliance, while multivariate analysis was performed to determine the dominant influencing factors. The knowledge, attitude, family support, and health worker support had a significant relationship with patient compliance (p < 0.05). Health worker support was a dominant factor with an Exp(B) value of 28.7, which means that patients with good health worker support have a 28.7 times greater chance of compliance. In contrast, access to health services did not show a significant relationship (p > 0.05). The compliance of tuberculosis patient’s is influenced by education, positive attitude, family support, and attention from health workers. Interventions focused on strengthening patient education and increasing support from health workers are recommended to improve the success of tuberculosis treatment.
EMPOWERING FOREST BATHING TOUR GUIDES FOR YOGURT PRODUCTION IN LEREP UNGARAN BARAT VILLAGE, SEMARANG REGENCY Susilorini, Susilorini; Yuniarifa, Conita; Hussaana, Atina; Riza, Mohamad
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 8 No. 1 (2024): MARET
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/abdidos.v8i1.2257

Abstract

Wellness tourism is a tourist activity that not only aims for entertainment and pleasure, but also health. Lerep Village is one of the tourist villages that has a lot of potential to be developed into one of the wellness tourism objects. One of the highlights is the culinary sold in the traditional Sunday Pon market based on local wisdom. Currently there is no development of yogurt-based products in this traditional market, even though there is a lot of potential from livestock and agricultural products that can be developed as yogurt products. Yogurt is one type of food rich in bacteria which is expected to be one way to maintain public health, especially digestive health. Tourism cadres in this village have long been fostered by the Faculty of Medicine of Sultan Agung Islamic University, especially in the development of forest bathing tourism. This service activity aims to provide basic education and training to 20 forest bathing tourism cadres in traditional yogurt making. The training was held for 1 day with counseling methods and one-day training. Before and after the training, the participants were given pretest and post test, and the results of a significant increase in knowledge were obtained from the participants. After this training, it is hoped that the tourism cadres can produce yogurt so that it can become one of the healthy snack choices in Lerep Tourism Village.
Co-Authors Anita Soraya Soetoko Atina Hussaana Djam'an, Qatrunnada Fatikhasari, Amalia Nurazima Joko Wahyu Wibowo Masfiyah Masfiyah, Masfiyah Nugroho, Bayu M.A Perez Wahyu Purnasari Riza, Mohamad Susilorini Susilorini, Susilorini Taufiqurrachman Nasihun Tsuraya, Ghefira Utami, Kamilia Dwi