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All Journal Journal of Pharmaceutical and Medicinal Sciences Jurnal Farmasi Indonesia
Sitti Rahimah Rachman
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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UJI TOKSISITAS EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) MENGGUNAKAN METODE BRINE SHRIMP LETHALITY TESt (BSLT) PADA LARVA UDANG (Artemia salina Leach Sitti Rahimah Rachman; Fadillah Maryam; Bertha Ayu Limbong
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 1 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.409 KB) | DOI: 10.32814/jpms.v4i1.82

Abstract

Brine Shrimp Lethality Test (BSLT) is one of the initial screening methods for testing cytotoxic compounds. Previous studies have scientifically proven that Averrhoa bilimbi L leaves have antioxidant effects so that the basis of the aim of this study is to determine the toxicity effects of ethanol extracts of starfruit starfruit shrimp (Artemia salina L.) using the BSLT method. Testing was done using several variations of concentration, namely 10 μg / mL, 250 μg / mL, 500 μg / mL, 750 μg / mL, and 1000 μg / mL. Based on observations and analysis of data obtained that the ethanol extract of Averrhoa bilimbi L leaves gives a moderate toxic effect with LC50 value of 367,282 ± 33.81 µg / mL.
Uji Toksisitas Subakut Ekstrak Etanol Daun Asam Jawa Dosis Efektif Sebagai Antihiperglikemia Terhadap Kadar AST, ALT, dan Kreatinin Tikus (Rattus norvegicus) Sitti Rahimah Rachman; Dzulkifli Dzulkifli; Suwahyuni Suwahyuni; Rahmad Aksa; Mirnawati Salampe; Akbar Awaluddin
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.1096

Abstract

The toxicity test is one of the pharmacological testing stages that must be carried out to assess the use of a drug. Research on the activity test of the ethanol extract of Tamarind leaves (Tamrindus indica L) at a dose of 14 mg / 200 g BW as an antihyperglycemia in experimental animals gave results that were not significantly different from the standard drug activity of Glibenclamide as an antidiabetic mellitus, so this study was conducted with the aim of looking at the ethanol of tamarind leaves. (Tamrindus indica L) for 30 days on levels of the enzymes AST, ALT, and creatinine in rats (Rattus norvegicus). This sub-acute toxicity test used 14 test animals divided into 2 groups, each group consisting of 7 rats. Group I was given 0.5% Na CMC treatment as a control and group II was treated with the ethanol extract of tamarind leaves at a dose of 14 mg / 200 g BW for 30 days. On the 31st day, blood serum measurements were taken with AST, ALT and creatinine parameters using a humalyzer. The results of the subacute toxicity test showed that giving tamarind leaves ethanol extract as an antihyperglycemia did not cause an increase in the AST, ALT AND creatinine enzymes beyond normal limits.
Co-Authors Akbar Awaluddin Bertha Ayu Limbong Dzulkifli Dzulkifli Fadillah Maryam Mirnawati Salampe Rahmad Aksa Suwahyuni Suwahyuni