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Suprapto Ma’at
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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DIFFERENCES OF LYMPHOCYTE PROLIFERATION INDEX AFTER CULTURE FILTRATE PROTEIN 10 STIMULATION IN PATIENTS WITH ACTIVE AND LATENT TUBERCULOSIS AND HEALTHY INDIVIDUALS Binar R. Utami; Betty Agustina T; Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 2 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i2.1144

Abstract

Angka kejadian tuberkulosis di dunia semakin meningkat, akibat rendahnya ketepatgunaan vaksin BCG untuk pencegahan infeksi TB.Saat ini telah dikembangkan vaksin DNA dari protein M.tuberculosis yaitu Culture filtrate protein-10 (CFP-10) yang dapat merangsangrespons imun seluler. Tujuan penelitian ini adalah mengetahui salah satu kemampuan antigenik antigen CFP-10 pasca stimulasi CFP-10 di pasien TB aktif, TB laten dan orang sehat. Penelitian bersifat eksperimen semu (quasi experimental). Sampel penelitian adalahPeripheral blood mononuclear cell (PBMC) dari 10 pasien TB paru aktif baru, 10 TB laten RS Khusus Paru Surabaya dan 10 orangsehat. Perlakuan kultur PBMC tanpa stimulasi (pembanding), dengan Mitogen (PHA) sebagai pembanding positif dan dengan stimulasiantigen CFP-10 diinkubasi pada CO2 5% selama 5 hari. Uji proliferasi limfosit dilakukan dengan menambahkan MTT. Indeks proliferasilimfosit adalah rasio antara absorban pembanding dan absorban dengan stimulasi pada λ 560 nm. Terdapat perbedaan bermakna indeksuji proliferasi limfosit pascastimulasi CFP-10 antara pasien TB paru aktif dan orang sehat (p=0,019) dan di pasien TB aktif, TB latendan orang sehat (p=0,0356). Antigen CFP 10 mampu merangsang respons imun protektif pada pasien TB aktif, TB laten dan orangsehat. Aktivitas imunogenik antigen CFP-10 dapat dipengaruhi oleh status imun seseorang dan kemampuan antigen CFP menginduksirespons imun protektif.
MENAHAN ATAU MENEKAN KEKEBALAN (IMUNOSUPRESI) UNTUK PENCANGKOKAN GINJAL (Bagian II) Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 3 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i3.936

Abstract

Renal transplantation is the treatment of choice for most patients with end stage renal disease. Most of the time, transplantationrejection is immunological mediated. Both T cells and circulating antibodies are induced against allograft. Successful organtransplantation requires the use of immunosuppressive drugs to prevent the host’s immune system from rejecting the transplanted organ.The development of immunosuppressive drugs is the key to successful allograft function Immunosuppressive agents are used for induction(intense immunosuppressant in the initial days after transplantation), maintenance and reversal of established rejection. This reviewfocuses on agents that are either approved or in phase 2 or phase 3 trials in kidney transplantation.
IMMATURE PLATELET FRACTION (IPF) DAN TROMBOPOIETIN DI SIROSIS HATI Esti Rohani; Yetti Hernaningsih; Suprapto Ma’at; Ummi Maimunah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 2 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i2.1066

Abstract

Liver cirrhosis remains a major clinical problem worldwide when associated with significant morbidity and mortality due toits complications. The presence of liver cirrhosis state affects the production of TPO influencing the process of thrombopoiesis. Thethrombopoiesis activity can be described by the Immature Platelet Fraction (IPF) value which is young platelets. The immature Plateletfraction value increases when platelet production enhances as well, on the contrary when the production declines, the IPF value is alsodecreased. This study was performed by cross-sectional method using 31 subject samples suffering from liver cirrhosis, consisting of ChildPugh score class A 2 samples (6.4%), Child Pugh score class B 9 samples (29%) and Child Pugh score class C 20 samples (64.6%). Theexamination of TPO levels was done by ELISA method using Humans TPO QuantikineR, the IPF value was examined using Sysmex XE-2100 Hematology Analyzer. The thrombopoietin serum levels in the samples ranged from 23.5 to 96.6 pg/mL with a mean of 45.1pg/mL.The immature Platelet Fraction values varied from 1.7% to 19.1% with a mean of 6.7%. From the statistical analysis, the levels of TPO andIPF at various degrees of the disease severity were not significantly different. There was no significant correlation between the TPO leveland IPF value, r = 0.038, p = 0.837. There was no significant difference between the TPO level and the IPF value in the splenomegaly andnonsplenomegaly state. In conclusion, based on this study no significant correlation was found between the IPF value with thrombopoietinserum levels, as well as the IPF and thrombopoietin levels, and there was no association with the disease severity.
Toll-like Receptor (TLR) dan Imunitas Natura Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 3 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i3.978

Abstract

In all living species, the first line of defence against microbial aggressions is constituted by innate immunity. Toll-like receptors(TLRs) are a family of pattern recognition receptors that are activated by specific components of microbes and certain host molecules.They constitute the first line of defense against many pathogens and play a crucial role in the function of the innate immune system.Recognition of pathogen-associated molecular pattern (PAMP) by TLR, alone or heterodimerization with other TLR or non-TLR receptors,induces signals responsible for the activation of genes important for an effective host defense, especially proinflammatory cytokines, orinitiates signal transduction pathways, which trigger expression of genes. These gene products control innate immune responses andfurther instruct development of antigen-specific acquired immunity.
IMUNOSUPRESI UNTUK PENCANGKOKAN GINJAL (Bagian I) Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.905

Abstract

Renal transplantation is the treatment of choice for most patients with end stage renal disease. Most of the time, transplantationrejection is immunological mediated. Both T cells and circulating antibodies are induced against allograft. Successful organtransplantation requires the use of immunosuppressive drugs to prevent the host’s immune system from rejecting the transplanted organ.The development of immunosuppressive drugs is the key to successful allograft function Immunosuppressive agents are used for induction(intense immunosuppressant in the initial days after transplantation), maintenance and reversal of established rejection. This reviewfocuses on agents that are either approved or in phase 2 or phase 3 trials in kidney transplantation.
KUNYIT PUTIH DAN BUAH MENGKUDU SEBAGAI HEPATOPROTEKTOR TERKAIT KARBON TETRAKLORIDA Suprapto Ma’at
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 1 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i1.389

Abstract

Herbal remedies are prescribed for the treatment of various liver diseases including for Hepatoprotector purpose. The present study was aimed to investigate and to know the hepatoprotective activity of Curcuma zedoaria extract combined with Morinda citrifolia extract against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Liver functions were assessed by the determination of SGOT, SGPT, ALP, and bilirubin. The results of serum analysis suggest that the use of Curcuma zedoaria extract combined with Morinda citrifolia extract exhibited significant protective effect related to the hepatic damage in CCl4 induced hepatotoxicity model and further evidence of its hepatoprotective activity
Co-Authors Betty Agustina T Binar R. Utami Esti Rohani Ummi Maimunah Yetti Hernaningsih